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Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.
Burns. 2006 Dec; 32(8):973-9.B

Abstract

The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnevotínská 3, 77515 Olomouc, Czech Republic. alf.svoboda@seznam.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17011711

Citation

Svobodová, Alena, et al. "Influence of Silymarin and Its Flavonolignans On H(2)O(2)-induced Oxidative Stress in Human Keratinocytes and Mouse Fibroblasts." Burns : Journal of the International Society for Burn Injuries, vol. 32, no. 8, 2006, pp. 973-9.
Svobodová A, Walterová D, Psotová J. Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts. Burns. 2006;32(8):973-9.
Svobodová, A., Walterová, D., & Psotová, J. (2006). Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts. Burns : Journal of the International Society for Burn Injuries, 32(8), 973-9.
Svobodová A, Walterová D, Psotová J. Influence of Silymarin and Its Flavonolignans On H(2)O(2)-induced Oxidative Stress in Human Keratinocytes and Mouse Fibroblasts. Burns. 2006;32(8):973-9. PubMed PMID: 17011711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts. AU - Svobodová,Alena, AU - Walterová,Daniela, AU - Psotová,Jitka, Y1 - 2006/09/29/ PY - 2006/02/01/received PY - 2006/04/04/accepted PY - 2006/10/3/pubmed PY - 2007/4/28/medline PY - 2006/10/3/entrez SP - 973 EP - 9 JF - Burns : journal of the International Society for Burn Injuries JO - Burns VL - 32 IS - 8 N2 - The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration. SN - 0305-4179 UR - https://www.unboundmedicine.com/medline/citation/17011711/Influence_of_silymarin_and_its_flavonolignans_on_H_2_O_2__induced_oxidative_stress_in_human_keratinocytes_and_mouse_fibroblasts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0305-4179(06)00122-7 DB - PRIME DP - Unbound Medicine ER -