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Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study).
Scand Cardiovasc J. 2006 Oct; 40(5):274-9.SC

Abstract

OBJECTIVE

Endothelial dysfunction and oxidative stress are involved in atherogenesis. In the search for predictors of vascular disease markers for endothelial dysfunction and oxidative stress were analyzed.

METHODS

Of 208 consecutive patients 22% were controls (CO) without coronary artery disease (CAD), 52% presented with stable angina (SAP) and 26% had acute coronary syndromes (ACS). Nitric oxide (NO), thrombomodulin (TM), von Willebrand factor (vW), sVCAM-1, sICAM-1, sP-selectin, sE-selectin, sL-selectin and C-reactive protein (CRP) were determined as markers for endothelial dysfunction, glutathione (GSH), glutathione peroxidase (Gpx), myeloperoxidase (Mpx), lipid peroxides (Lpx), 8-isoprostane (Iso), superoxide dismutase (SOD), total antioxidant capacity (TAC) and homocysteine (Hc) as markers for oxidative stress.

RESULTS

The increases of TM, vW, sVCAM-1, CRP, SOD and Mpx correlated with the CAD status in the order CO < SAP < ACS, whereas NO and sL-selectin were inversely correlated (p < 0.05, resp.). The other markers remained unchanged. For several markers a significant relationship to risk factors was detected.

CONCLUSIONS

Markers for endothelial dysfunction rather than those for oxidative stress may serve as indicators for the presence and severity of CAD.

Authors+Show Affiliations

Red Cross Hospital Cardiology Center, Frankfurt, Germany. j.ruef@kardiocentrum-ffm.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17012137

Citation

Ruef, Johannes, et al. "Markers for Endothelial Dysfunction, but Not Markers for Oxidative Stress Correlate With Classical Risk Factors and the Severity of Coronary Artery Disease. (A Subgroup Analysis From the Ludwigshafen Risk and Cardiovascular Health Study)." Scandinavian Cardiovascular Journal : SCJ, vol. 40, no. 5, 2006, pp. 274-9.
Ruef J, März W, Winkelmann BR. Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study). Scand Cardiovasc J. 2006;40(5):274-9.
Ruef, J., März, W., & Winkelmann, B. R. (2006). Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study). Scandinavian Cardiovascular Journal : SCJ, 40(5), 274-9.
Ruef J, März W, Winkelmann BR. Markers for Endothelial Dysfunction, but Not Markers for Oxidative Stress Correlate With Classical Risk Factors and the Severity of Coronary Artery Disease. (A Subgroup Analysis From the Ludwigshafen Risk and Cardiovascular Health Study). Scand Cardiovasc J. 2006;40(5):274-9. PubMed PMID: 17012137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study). AU - Ruef,Johannes, AU - März,Winfried, AU - Winkelmann,Bernhard R, PY - 2006/10/3/pubmed PY - 2007/6/9/medline PY - 2006/10/3/entrez SP - 274 EP - 9 JF - Scandinavian cardiovascular journal : SCJ JO - Scand Cardiovasc J VL - 40 IS - 5 N2 - OBJECTIVE: Endothelial dysfunction and oxidative stress are involved in atherogenesis. In the search for predictors of vascular disease markers for endothelial dysfunction and oxidative stress were analyzed. METHODS: Of 208 consecutive patients 22% were controls (CO) without coronary artery disease (CAD), 52% presented with stable angina (SAP) and 26% had acute coronary syndromes (ACS). Nitric oxide (NO), thrombomodulin (TM), von Willebrand factor (vW), sVCAM-1, sICAM-1, sP-selectin, sE-selectin, sL-selectin and C-reactive protein (CRP) were determined as markers for endothelial dysfunction, glutathione (GSH), glutathione peroxidase (Gpx), myeloperoxidase (Mpx), lipid peroxides (Lpx), 8-isoprostane (Iso), superoxide dismutase (SOD), total antioxidant capacity (TAC) and homocysteine (Hc) as markers for oxidative stress. RESULTS: The increases of TM, vW, sVCAM-1, CRP, SOD and Mpx correlated with the CAD status in the order CO < SAP < ACS, whereas NO and sL-selectin were inversely correlated (p < 0.05, resp.). The other markers remained unchanged. For several markers a significant relationship to risk factors was detected. CONCLUSIONS: Markers for endothelial dysfunction rather than those for oxidative stress may serve as indicators for the presence and severity of CAD. SN - 1401-7431 UR - https://www.unboundmedicine.com/medline/citation/17012137/Markers_for_endothelial_dysfunction_but_not_markers_for_oxidative_stress_correlate_with_classical_risk_factors_and_the_severity_of_coronary_artery_disease___A_subgroup_analysis_from_the_Ludwigshafen_Risk_and_Cardiovascular_Health_Study__ L2 - https://www.tandfonline.com/doi/full/10.1080/14017430600925300 DB - PRIME DP - Unbound Medicine ER -