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Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury.
Scand Cardiovasc J. 2006 Oct; 40(5):312-7.SC

Abstract

OBJECTIVE

To test the hypothesis that limb ischemic postconditioning protects the myocardium from reperfusion injury, and examine the mechanism involved.

DESIGN

Forty rabbits were randomly divided into four groups: Control, Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning. Myocardial infarct size and tissue myeloperoxidase activity were determined at the end of the experiment. Plasma creatine kinase and malondialdehyde activity were measured at baseline, the end of ischemia, and after 3 h of reperfusion respectively.

RESULTS

Myocardial infarct size was significantly reduced in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning as compared to Control (p < 0.01). Results were confirmed by plasma creatine kinase activity. Plasma malondialdehyde was significantly less at 3 h of reperfusion in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01). Neutrophil accumulation (myeloperoxidase activity) in the area at risk was less in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01).

CONCLUSION

Remote postconditioning reduces myocardial infarction in rabbits. The mechanism involved might be reduced oxygen radical-induced injury and improved antioxidant action.

Authors+Show Affiliations

Department of Cardiology, Shandong Provincial Hospital of Shandong University, Jinan, 250021, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17012143

Citation

Li, Chun-Mei, et al. "Limb Ischemic Postconditioning Protects Myocardium From Ischemia-reperfusion Injury." Scandinavian Cardiovascular Journal : SCJ, vol. 40, no. 5, 2006, pp. 312-7.
Li CM, Zhang XH, Ma XJ, et al. Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury. Scand Cardiovasc J. 2006;40(5):312-7.
Li, C. M., Zhang, X. H., Ma, X. J., & Luo, M. (2006). Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury. Scandinavian Cardiovascular Journal : SCJ, 40(5), 312-7.
Li CM, et al. Limb Ischemic Postconditioning Protects Myocardium From Ischemia-reperfusion Injury. Scand Cardiovasc J. 2006;40(5):312-7. PubMed PMID: 17012143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury. AU - Li,Chun-Mei, AU - Zhang,Xing-Hua, AU - Ma,Xiao-Jing, AU - Luo,Man, PY - 2006/10/3/pubmed PY - 2007/6/9/medline PY - 2006/10/3/entrez SP - 312 EP - 7 JF - Scandinavian cardiovascular journal : SCJ JO - Scand Cardiovasc J VL - 40 IS - 5 N2 - OBJECTIVE: To test the hypothesis that limb ischemic postconditioning protects the myocardium from reperfusion injury, and examine the mechanism involved. DESIGN: Forty rabbits were randomly divided into four groups: Control, Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning. Myocardial infarct size and tissue myeloperoxidase activity were determined at the end of the experiment. Plasma creatine kinase and malondialdehyde activity were measured at baseline, the end of ischemia, and after 3 h of reperfusion respectively. RESULTS: Myocardial infarct size was significantly reduced in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning as compared to Control (p < 0.01). Results were confirmed by plasma creatine kinase activity. Plasma malondialdehyde was significantly less at 3 h of reperfusion in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01). Neutrophil accumulation (myeloperoxidase activity) in the area at risk was less in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01). CONCLUSION: Remote postconditioning reduces myocardial infarction in rabbits. The mechanism involved might be reduced oxygen radical-induced injury and improved antioxidant action. SN - 1401-7431 UR - https://www.unboundmedicine.com/medline/citation/17012143/Limb_ischemic_postconditioning_protects_myocardium_from_ischemia_reperfusion_injury_ DB - PRIME DP - Unbound Medicine ER -