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CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain 2006; 129(Pt 11):3035-41B

Abstract

Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease.

Authors+Show Affiliations

Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University Munich, Germany. katharina.buerger@med.uni-muenchen.de

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17012293

Citation

Buerger, Katharina, et al. "CSF Phosphorylated Tau Protein Correlates With Neocortical Neurofibrillary Pathology in Alzheimer's Disease." Brain : a Journal of Neurology, vol. 129, no. Pt 11, 2006, pp. 3035-41.
Buerger K, Ewers M, Pirttilä T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain. 2006;129(Pt 11):3035-41.
Buerger, K., Ewers, M., Pirttilä, T., Zinkowski, R., Alafuzoff, I., Teipel, S. J., ... Hampel, H. (2006). CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a Journal of Neurology, 129(Pt 11), pp. 3035-41.
Buerger K, et al. CSF Phosphorylated Tau Protein Correlates With Neocortical Neurofibrillary Pathology in Alzheimer's Disease. Brain. 2006;129(Pt 11):3035-41. PubMed PMID: 17012293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. AU - Buerger,Katharina, AU - Ewers,Michael, AU - Pirttilä,Tuula, AU - Zinkowski,Raymond, AU - Alafuzoff,Irina, AU - Teipel,Stefan J, AU - DeBernardis,John, AU - Kerkman,Daniel, AU - McCulloch,Cheryl, AU - Soininen,Hilkka, AU - Hampel,Harald, Y1 - 2006/09/29/ PY - 2006/10/3/pubmed PY - 2006/12/12/medline PY - 2006/10/3/entrez SP - 3035 EP - 41 JF - Brain : a journal of neurology JO - Brain VL - 129 IS - Pt 11 N2 - Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/17012293/CSF_phosphorylated_tau_protein_correlates_with_neocortical_neurofibrillary_pathology_in_Alzheimer's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl269 DB - PRIME DP - Unbound Medicine ER -