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CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain 2006; 129(Pt 11):3035-41B

Abstract

Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease.

Authors+Show Affiliations

Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University Munich, Germany. katharina.buerger@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17012293

Citation

Buerger, Katharina, et al. "CSF Phosphorylated Tau Protein Correlates With Neocortical Neurofibrillary Pathology in Alzheimer's Disease." Brain : a Journal of Neurology, vol. 129, no. Pt 11, 2006, pp. 3035-41.
Buerger K, Ewers M, Pirttilä T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain. 2006;129(Pt 11):3035-41.
Buerger, K., Ewers, M., Pirttilä, T., Zinkowski, R., Alafuzoff, I., Teipel, S. J., ... Hampel, H. (2006). CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a Journal of Neurology, 129(Pt 11), pp. 3035-41.
Buerger K, et al. CSF Phosphorylated Tau Protein Correlates With Neocortical Neurofibrillary Pathology in Alzheimer's Disease. Brain. 2006;129(Pt 11):3035-41. PubMed PMID: 17012293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. AU - Buerger,Katharina, AU - Ewers,Michael, AU - Pirttilä,Tuula, AU - Zinkowski,Raymond, AU - Alafuzoff,Irina, AU - Teipel,Stefan J, AU - DeBernardis,John, AU - Kerkman,Daniel, AU - McCulloch,Cheryl, AU - Soininen,Hilkka, AU - Hampel,Harald, Y1 - 2006/09/29/ PY - 2006/10/3/pubmed PY - 2006/12/12/medline PY - 2006/10/3/entrez SP - 3035 EP - 41 JF - Brain : a journal of neurology JO - Brain VL - 129 IS - Pt 11 N2 - Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/17012293/CSF_phosphorylated_tau_protein_correlates_with_neocortical_neurofibrillary_pathology_in_Alzheimer's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl269 DB - PRIME DP - Unbound Medicine ER -