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Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically.
Parasitol Res. 2007 Feb; 100(3):473-8.PR

Abstract

Foals (79), born in 2004 on three thoroughbred horse farms (C, M, and S) in central Kentucky, were fed pyrantel tartrate daily, beginning at about 3 months of age. In addition, other parasiticides [fenbendazole (FBZ), ivermectin (IVM) alone or with praziquantel (PRAZ), oxibendazole (OBZ), pyrantel pamoate (PRT), and moxidectin (MOX)] were given periodically. All treatments were administered by farm personnel. Over a 14-month period, from May 2004 to July 2005, collections (n=989) of feces were made from the foals for determination of presence of internal parasite eggs/oocysts by qualitative and/or quantitative methods. Conclusions on drug activity are based necessarily on considering the combined effect of pyrantel tartrate and the other compounds. For small strongyles, this was related to which specific additional compound was given. Based on the percentage of foals with strongyle-egg-positive feces and/or the level of eggs per gram of feces (EPG) counts for the foals after treatment, drug activity on small strongyles was highest to lowest for MOX, IVM and IVM/PRAZ, FBZ, OBZ, PRT, and FBZ (2x for 5 days). The macrocyclic lactones (MOX and IVM) were highly superior to the other compounds. Some of the strongyle counts were high (over 2,000), especially on one farm (S), during periods when foals received only pyrantel tartrate, but a few days after administration of therapeutic dose rates of the drugs IVM or MOX, they were negative or very low. Ascarid eggs were present in feces of three foals after treatment with a combination of IVM and PRAZ. The qualitative method was more efficient than the quantitative method in detection of ascarid and strongyle eggs in the feces. Prevalence of eggs of ascarids (Parascaris equorum) was low (0, 4, and 31%), of strongyles high (80, 100, and 100%), of Strongyloides westeri very low (only one infected foal), and oocysts of Eimeria leuckarti medium to high (36, 41, and 85%) for the three farms, C, M, and S, respectively. It is uncertain whether the low ascarid prevalence was from activity of pyrantel tartrate and/or the other drugs or to a limited source of infective eggs.

Authors+Show Affiliations

Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA. elyons1@uky.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17013652

Citation

Lyons, E T., et al. "Parasite Field Study in Central Kentucky On Thoroughbred Foals (born in 2004) Treated With Pyrantel Tartrate Daily and Other Parasiticides Periodically." Parasitology Research, vol. 100, no. 3, 2007, pp. 473-8.
Lyons ET, Tolliver SC, Rathgeber RA, et al. Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically. Parasitol Res. 2007;100(3):473-8.
Lyons, E. T., Tolliver, S. C., Rathgeber, R. A., & Collins, S. S. (2007). Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically. Parasitology Research, 100(3), 473-8.
Lyons ET, et al. Parasite Field Study in Central Kentucky On Thoroughbred Foals (born in 2004) Treated With Pyrantel Tartrate Daily and Other Parasiticides Periodically. Parasitol Res. 2007;100(3):473-8. PubMed PMID: 17013652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically. AU - Lyons,E T, AU - Tolliver,S C, AU - Rathgeber,R A, AU - Collins,S S, Y1 - 2006/09/30/ PY - 2006/05/05/received PY - 2006/07/17/accepted PY - 2006/10/3/pubmed PY - 2007/9/20/medline PY - 2006/10/3/entrez SP - 473 EP - 8 JF - Parasitology research JO - Parasitol Res VL - 100 IS - 3 N2 - Foals (79), born in 2004 on three thoroughbred horse farms (C, M, and S) in central Kentucky, were fed pyrantel tartrate daily, beginning at about 3 months of age. In addition, other parasiticides [fenbendazole (FBZ), ivermectin (IVM) alone or with praziquantel (PRAZ), oxibendazole (OBZ), pyrantel pamoate (PRT), and moxidectin (MOX)] were given periodically. All treatments were administered by farm personnel. Over a 14-month period, from May 2004 to July 2005, collections (n=989) of feces were made from the foals for determination of presence of internal parasite eggs/oocysts by qualitative and/or quantitative methods. Conclusions on drug activity are based necessarily on considering the combined effect of pyrantel tartrate and the other compounds. For small strongyles, this was related to which specific additional compound was given. Based on the percentage of foals with strongyle-egg-positive feces and/or the level of eggs per gram of feces (EPG) counts for the foals after treatment, drug activity on small strongyles was highest to lowest for MOX, IVM and IVM/PRAZ, FBZ, OBZ, PRT, and FBZ (2x for 5 days). The macrocyclic lactones (MOX and IVM) were highly superior to the other compounds. Some of the strongyle counts were high (over 2,000), especially on one farm (S), during periods when foals received only pyrantel tartrate, but a few days after administration of therapeutic dose rates of the drugs IVM or MOX, they were negative or very low. Ascarid eggs were present in feces of three foals after treatment with a combination of IVM and PRAZ. The qualitative method was more efficient than the quantitative method in detection of ascarid and strongyle eggs in the feces. Prevalence of eggs of ascarids (Parascaris equorum) was low (0, 4, and 31%), of strongyles high (80, 100, and 100%), of Strongyloides westeri very low (only one infected foal), and oocysts of Eimeria leuckarti medium to high (36, 41, and 85%) for the three farms, C, M, and S, respectively. It is uncertain whether the low ascarid prevalence was from activity of pyrantel tartrate and/or the other drugs or to a limited source of infective eggs. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/17013652/Parasite_field_study_in_central_Kentucky_on_thoroughbred_foals__born_in_2004__treated_with_pyrantel_tartrate_daily_and_other_parasiticides_periodically_ L2 - https://dx.doi.org/10.1007/s00436-006-0289-6 DB - PRIME DP - Unbound Medicine ER -