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Immunoregulatory function of mesenchymal stem cells.
Eur J Immunol. 2006 Oct; 36(10):2566-73.EJ

Abstract

Mesenchymal stem cells (MSC) are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. MSC can differentiate into multiple mesenchymal and non-mesenchymal lineages, providing a promising tool for tissue repair. In addition, MSC suppress many T cell, B cell and NK cell functions and may affect also dendritic cell activities. Due to their limited immunogenicity, MSC are poorly recognized by HLA-incompatible hosts. Based on these unique properties, MSC are currently under investigation for their possible use to treat immuno-mediated diseases. However, both their condition of immunoprivilege and their immunosuppressive function have recently been challenged when analyzed under particular experimental conditions. Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions.

Authors+Show Affiliations

Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy. auccelli@neurologia.unige.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17013987

Citation

Uccelli, Antonio, et al. "Immunoregulatory Function of Mesenchymal Stem Cells." European Journal of Immunology, vol. 36, no. 10, 2006, pp. 2566-73.
Uccelli A, Moretta L, Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol. 2006;36(10):2566-73.
Uccelli, A., Moretta, L., & Pistoia, V. (2006). Immunoregulatory function of mesenchymal stem cells. European Journal of Immunology, 36(10), 2566-73.
Uccelli A, Moretta L, Pistoia V. Immunoregulatory Function of Mesenchymal Stem Cells. Eur J Immunol. 2006;36(10):2566-73. PubMed PMID: 17013987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoregulatory function of mesenchymal stem cells. AU - Uccelli,Antonio, AU - Moretta,Lorenzo, AU - Pistoia,Vito, PY - 2006/10/3/pubmed PY - 2006/12/9/medline PY - 2006/10/3/entrez SP - 2566 EP - 73 JF - European journal of immunology JO - Eur. J. Immunol. VL - 36 IS - 10 N2 - Mesenchymal stem cells (MSC) are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. MSC can differentiate into multiple mesenchymal and non-mesenchymal lineages, providing a promising tool for tissue repair. In addition, MSC suppress many T cell, B cell and NK cell functions and may affect also dendritic cell activities. Due to their limited immunogenicity, MSC are poorly recognized by HLA-incompatible hosts. Based on these unique properties, MSC are currently under investigation for their possible use to treat immuno-mediated diseases. However, both their condition of immunoprivilege and their immunosuppressive function have recently been challenged when analyzed under particular experimental conditions. Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/17013987/Immunoregulatory_function_of_mesenchymal_stem_cells_ L2 - https://doi.org/10.1002/eji.200636416 DB - PRIME DP - Unbound Medicine ER -