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FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Dev Biol. 2007 Feb 01; 302(1):80-91.DB

Abstract

Fibroblast growth factor 18 (FGF18) has been shown to regulate chondrocyte proliferation and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by signaling through other FGFRs. Fgf18(-/-) mice have an apparent delay in skeletal mineralization that is not seen in Fgfr3(-/-) mice. However, this delay in mineralization could not be simply explained by FGF18 signaling to osteoblasts. Here we show that delayed mineralization in Fgf18(-/-) mice was closely associated with delayed initiation of chondrocyte hypertrophy, decreased proliferation at early stages of chondrogenesis, delayed skeletal vascularization and delayed osteoclast and osteoblast recruitment to the growth plate. We further show that FGF18 is necessary for Vegf expression in hypertrophic chondrocytes and the perichondrium and is sufficient to induce Vegf expression in skeletal explants. These findings support a model in which FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts/osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. FGF18 thus coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation.

Authors+Show Affiliations

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17014841

Citation

Liu, Zhonghao, et al. "FGF18 Is Required for Early Chondrocyte Proliferation, Hypertrophy and Vascular Invasion of the Growth Plate." Developmental Biology, vol. 302, no. 1, 2007, pp. 80-91.
Liu Z, Lavine KJ, Hung IH, et al. FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol. 2007;302(1):80-91.
Liu, Z., Lavine, K. J., Hung, I. H., & Ornitz, D. M. (2007). FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Developmental Biology, 302(1), 80-91.
Liu Z, et al. FGF18 Is Required for Early Chondrocyte Proliferation, Hypertrophy and Vascular Invasion of the Growth Plate. Dev Biol. 2007 Feb 1;302(1):80-91. PubMed PMID: 17014841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. AU - Liu,Zhonghao, AU - Lavine,Kory J, AU - Hung,Irene H, AU - Ornitz,David M, Y1 - 2006/09/05/ PY - 2006/06/09/received PY - 2006/08/29/revised PY - 2006/08/30/accepted PY - 2006/10/4/pubmed PY - 2007/3/7/medline PY - 2006/10/4/entrez SP - 80 EP - 91 JF - Developmental biology JO - Dev. Biol. VL - 302 IS - 1 N2 - Fibroblast growth factor 18 (FGF18) has been shown to regulate chondrocyte proliferation and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by signaling through other FGFRs. Fgf18(-/-) mice have an apparent delay in skeletal mineralization that is not seen in Fgfr3(-/-) mice. However, this delay in mineralization could not be simply explained by FGF18 signaling to osteoblasts. Here we show that delayed mineralization in Fgf18(-/-) mice was closely associated with delayed initiation of chondrocyte hypertrophy, decreased proliferation at early stages of chondrogenesis, delayed skeletal vascularization and delayed osteoclast and osteoblast recruitment to the growth plate. We further show that FGF18 is necessary for Vegf expression in hypertrophic chondrocytes and the perichondrium and is sufficient to induce Vegf expression in skeletal explants. These findings support a model in which FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts/osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. FGF18 thus coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation. SN - 0012-1606 UR - https://www.unboundmedicine.com/medline/citation/17014841/FGF18_is_required_for_early_chondrocyte_proliferation_hypertrophy_and_vascular_invasion_of_the_growth_plate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-1606(06)01177-8 DB - PRIME DP - Unbound Medicine ER -