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Xanthine oxidase inhibitory activity of some Indian medical plants.
J Ethnopharmacol. 2007 Feb 12; 109(3):547-51.JE

Abstract

Xanthine oxidase inhibitory activity was assayed from six species belonging to different families traditionally used for the treatment of gout and related symptoms by indigenous people of India. The aqueous, methanol-water mixture and methanolic extract of these plants were used for the experiment. Of the 18 extracts assayed, 14 extracts demonstrated xanthine oxidase inhibitory activity at 100 microg/ml, among which 10 extracts showed an inhibition greater than 50% and IC(50) values below 100 microg/ml. The methanolic extracts of Coccinia grandis, Datura metel, Strychnos nux-vomica and Vitex negundo showed more than 50% inhibition, hence, they were screened for their in vivo hypouricaemic activity against potassium oxonate-induced hyperuricaemia in mice. Methanolic extracts of Coccinia grandis and Vitex negundo showed a significant decrease in the serum urate level (3.90+/-0.07 mg/dl, P<0.001) and (6.26+/-0.06 mg/dl, P<0.01), respectively, when compared to hyperuricaemic control (11.42+/-0.14 mg/dl). This effect is almost similar to the serum urate level of allopurinol (3.89+/-0.07 mg/dl).

Authors+Show Affiliations

Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Siddhapudur, Coimbatore 641044, Tamil Nadu, India. umasaravanaprakash@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17014977

Citation

Umamaheswari, Muthuswamy, et al. "Xanthine Oxidase Inhibitory Activity of some Indian Medical Plants." Journal of Ethnopharmacology, vol. 109, no. 3, 2007, pp. 547-51.
Umamaheswari M, AsokKumar K, Somasundaram A, et al. Xanthine oxidase inhibitory activity of some Indian medical plants. J Ethnopharmacol. 2007;109(3):547-51.
Umamaheswari, M., AsokKumar, K., Somasundaram, A., Sivashanmugam, T., Subhadradevi, V., & Ravi, T. K. (2007). Xanthine oxidase inhibitory activity of some Indian medical plants. Journal of Ethnopharmacology, 109(3), 547-51.
Umamaheswari M, et al. Xanthine Oxidase Inhibitory Activity of some Indian Medical Plants. J Ethnopharmacol. 2007 Feb 12;109(3):547-51. PubMed PMID: 17014977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthine oxidase inhibitory activity of some Indian medical plants. AU - Umamaheswari,Muthuswamy, AU - AsokKumar,Kuppusamy, AU - Somasundaram,Arumugam, AU - Sivashanmugam,Thirumalaisamy, AU - Subhadradevi,Varadharajan, AU - Ravi,Thenvungal Kochupapy, Y1 - 2006/09/05/ PY - 2006/02/18/received PY - 2006/08/12/revised PY - 2006/08/22/accepted PY - 2006/10/4/pubmed PY - 2007/4/21/medline PY - 2006/10/4/entrez SP - 547 EP - 51 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 109 IS - 3 N2 - Xanthine oxidase inhibitory activity was assayed from six species belonging to different families traditionally used for the treatment of gout and related symptoms by indigenous people of India. The aqueous, methanol-water mixture and methanolic extract of these plants were used for the experiment. Of the 18 extracts assayed, 14 extracts demonstrated xanthine oxidase inhibitory activity at 100 microg/ml, among which 10 extracts showed an inhibition greater than 50% and IC(50) values below 100 microg/ml. The methanolic extracts of Coccinia grandis, Datura metel, Strychnos nux-vomica and Vitex negundo showed more than 50% inhibition, hence, they were screened for their in vivo hypouricaemic activity against potassium oxonate-induced hyperuricaemia in mice. Methanolic extracts of Coccinia grandis and Vitex negundo showed a significant decrease in the serum urate level (3.90+/-0.07 mg/dl, P<0.001) and (6.26+/-0.06 mg/dl, P<0.01), respectively, when compared to hyperuricaemic control (11.42+/-0.14 mg/dl). This effect is almost similar to the serum urate level of allopurinol (3.89+/-0.07 mg/dl). SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17014977/Xanthine_oxidase_inhibitory_activity_of_some_Indian_medical_plants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00418-1 DB - PRIME DP - Unbound Medicine ER -