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Prevalence of fatty liver in children and adolescents.
Pediatrics. 2006 Oct; 118(4):1388-93.Ped

Abstract

OBJECTIVE

Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample.

METHODS

We conducted a retrospective review of 742 children between the ages of 2 and 19 years who had an autopsy performed by a county medical examiner from 1993 to 2003. Fatty liver was defined as > or = 5% of hepatocytes containing macrovesicular fat.

RESULTS

Fatty liver was present in 13% of subjects. For children and adolescents age 2 to 19 years, the prevalence of fatty liver adjusted for age, gender, race, and ethnicity is estimated to be 9.6%. Fatty liver prevalence increases with age, ranging from 0.7% for ages 2 to 4 up to 17.3% for ages 15 to 19 years. Fatty liver prevalence differs significantly by race and ethnicity (Asian: 10.2%; black: 1.5%; Hispanic: 11.8%; white: 8.6%). The highest rate of fatty liver was seen in obese children (38%).

CONCLUSIONS

Fatty liver is the most common liver abnormality in children age 2 to 19 years. The presence of macrovesicular hepatic steatosis in approximately 1 of every 10 children has important ramifications for the long-term health of children and young adults. The influence of the risk factors identified should be taken into consideration in the development of protocols designed to screen at-risk children and adolescents.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, 200 West Arbor Dr, San Diego, CA 92103-8450, USA. jschwimmer@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17015527

Citation

Schwimmer, Jeffrey B., et al. "Prevalence of Fatty Liver in Children and Adolescents." Pediatrics, vol. 118, no. 4, 2006, pp. 1388-93.
Schwimmer JB, Deutsch R, Kahen T, et al. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118(4):1388-93.
Schwimmer, J. B., Deutsch, R., Kahen, T., Lavine, J. E., Stanley, C., & Behling, C. (2006). Prevalence of fatty liver in children and adolescents. Pediatrics, 118(4), 1388-93.
Schwimmer JB, et al. Prevalence of Fatty Liver in Children and Adolescents. Pediatrics. 2006;118(4):1388-93. PubMed PMID: 17015527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of fatty liver in children and adolescents. AU - Schwimmer,Jeffrey B, AU - Deutsch,Reena, AU - Kahen,Tanaz, AU - Lavine,Joel E, AU - Stanley,Christina, AU - Behling,Cynthia, PY - 2006/10/4/pubmed PY - 2006/10/13/medline PY - 2006/10/4/entrez SP - 1388 EP - 93 JF - Pediatrics JO - Pediatrics VL - 118 IS - 4 N2 - OBJECTIVE: Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample. METHODS: We conducted a retrospective review of 742 children between the ages of 2 and 19 years who had an autopsy performed by a county medical examiner from 1993 to 2003. Fatty liver was defined as > or = 5% of hepatocytes containing macrovesicular fat. RESULTS: Fatty liver was present in 13% of subjects. For children and adolescents age 2 to 19 years, the prevalence of fatty liver adjusted for age, gender, race, and ethnicity is estimated to be 9.6%. Fatty liver prevalence increases with age, ranging from 0.7% for ages 2 to 4 up to 17.3% for ages 15 to 19 years. Fatty liver prevalence differs significantly by race and ethnicity (Asian: 10.2%; black: 1.5%; Hispanic: 11.8%; white: 8.6%). The highest rate of fatty liver was seen in obese children (38%). CONCLUSIONS: Fatty liver is the most common liver abnormality in children age 2 to 19 years. The presence of macrovesicular hepatic steatosis in approximately 1 of every 10 children has important ramifications for the long-term health of children and young adults. The influence of the risk factors identified should be taken into consideration in the development of protocols designed to screen at-risk children and adolescents. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17015527/Prevalence_of_fatty_liver_in_children_and_adolescents_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=17015527 DB - PRIME DP - Unbound Medicine ER -