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Near elimination of hepatitis B virus infections among Hawaii elementary school children after universal infant hepatitis B vaccination.
Pediatrics. 2006 Oct; 118(4):1403-8.Ped

Abstract

OBJECTIVES

Hawaii implemented routine infant hepatitis B vaccination in 1992 and required it for school entry in 1997. Previously, in 1989, a serologic survey among Hawaii school children in grades 1 to 3 indicated that 1.6% had chronic hepatitis B virus infection, and 2.1% had resolved infection. We conducted a follow-up survey to examine changes in hepatitis B virus infection rates.

PATIENTS AND METHODS

This study was performed in Oahu, Hawaii, during the 2001-2002 school year among children in grades 2 and 3. Consenting parents/guardians provided demographic information including place of birth. Participants were tested for serologic evidence of hepatitis B virus infection and their vaccination status was determined by reviewing school records. Rates of symptomatic acute hepatitis B among persons aged < or = 19 years were calculated from cases reported from Hawaii to the Centers for Disease Control and Prevention between 1990 and 2004.

RESULTS

Completed hepatitis B vaccination series were documented for 83% of the 2469 participants by age 18 months and for 97% by age 5 years. Past or present hepatitis B virus infection was detected among 6 participants (0.24%), including 1 (0.04%) with chronic infection and 5 (0.20%) with resolved infections. Compared with the 1989 survey, these prevalences represent declines of 97% and 90% in chronic and resolved hepatitis B virus infections, respectively. The incidence of symptomatic acute hepatitis B in Hawaii children and adolescents aged < or = 19 years decreased from 4.5 cases per 100,000 in 1990 to 0.0 during 2002-2004. To date, the last reported case in a child aged < 15 years in Hawaii occurred in 1996.

CONCLUSIONS

Hepatitis B virus infection has nearly been eliminated in Hawaii children born after universal infant hepatitis B vaccination was implemented. These findings suggest that hepatitis B prevention goals are being met through routine immunization and related prevention programs among US children.

Authors+Show Affiliations

Division of Viral Hepatitis, Centers for Disease Control and Prevention, Department of Health and Human Services, 1600 Clifton Rd, Mailstop G-37, Atlanta, GA 30333, USA. jperz@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17015529

Citation

Perz, Joseph F., et al. "Near Elimination of Hepatitis B Virus Infections Among Hawaii Elementary School Children After Universal Infant Hepatitis B Vaccination." Pediatrics, vol. 118, no. 4, 2006, pp. 1403-8.
Perz JF, Elm JL, Fiore AE, et al. Near elimination of hepatitis B virus infections among Hawaii elementary school children after universal infant hepatitis B vaccination. Pediatrics. 2006;118(4):1403-8.
Perz, J. F., Elm, J. L., Fiore, A. E., Huggler, J. I., Kuhnert, W. L., & Effler, P. V. (2006). Near elimination of hepatitis B virus infections among Hawaii elementary school children after universal infant hepatitis B vaccination. Pediatrics, 118(4), 1403-8.
Perz JF, et al. Near Elimination of Hepatitis B Virus Infections Among Hawaii Elementary School Children After Universal Infant Hepatitis B Vaccination. Pediatrics. 2006;118(4):1403-8. PubMed PMID: 17015529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Near elimination of hepatitis B virus infections among Hawaii elementary school children after universal infant hepatitis B vaccination. AU - Perz,Joseph F, AU - Elm,Joseph L,Jr AU - Fiore,Anthony E, AU - Huggler,Janice I, AU - Kuhnert,Wendi L, AU - Effler,Paul V, PY - 2006/10/4/pubmed PY - 2006/10/13/medline PY - 2006/10/4/entrez SP - 1403 EP - 8 JF - Pediatrics JO - Pediatrics VL - 118 IS - 4 N2 - OBJECTIVES: Hawaii implemented routine infant hepatitis B vaccination in 1992 and required it for school entry in 1997. Previously, in 1989, a serologic survey among Hawaii school children in grades 1 to 3 indicated that 1.6% had chronic hepatitis B virus infection, and 2.1% had resolved infection. We conducted a follow-up survey to examine changes in hepatitis B virus infection rates. PATIENTS AND METHODS: This study was performed in Oahu, Hawaii, during the 2001-2002 school year among children in grades 2 and 3. Consenting parents/guardians provided demographic information including place of birth. Participants were tested for serologic evidence of hepatitis B virus infection and their vaccination status was determined by reviewing school records. Rates of symptomatic acute hepatitis B among persons aged < or = 19 years were calculated from cases reported from Hawaii to the Centers for Disease Control and Prevention between 1990 and 2004. RESULTS: Completed hepatitis B vaccination series were documented for 83% of the 2469 participants by age 18 months and for 97% by age 5 years. Past or present hepatitis B virus infection was detected among 6 participants (0.24%), including 1 (0.04%) with chronic infection and 5 (0.20%) with resolved infections. Compared with the 1989 survey, these prevalences represent declines of 97% and 90% in chronic and resolved hepatitis B virus infections, respectively. The incidence of symptomatic acute hepatitis B in Hawaii children and adolescents aged < or = 19 years decreased from 4.5 cases per 100,000 in 1990 to 0.0 during 2002-2004. To date, the last reported case in a child aged < 15 years in Hawaii occurred in 1996. CONCLUSIONS: Hepatitis B virus infection has nearly been eliminated in Hawaii children born after universal infant hepatitis B vaccination was implemented. These findings suggest that hepatitis B prevention goals are being met through routine immunization and related prevention programs among US children. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17015529/Near_elimination_of_hepatitis_B_virus_infections_among_Hawaii_elementary_school_children_after_universal_infant_hepatitis_B_vaccination_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=17015529 DB - PRIME DP - Unbound Medicine ER -