Tags

Type your tag names separated by a space and hit enter

Nongenetic causes of Parkinson's disease.
J Neural Transm Suppl 2006; (70):147-51JN

Abstract

Study of the nongenetic causes of Parkinson's disease (PD) was encouraged by discovery of a cluster of parkinsonism produced by neurotoxic pyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the 1980s. Since that time, epidemiologic investigations have suggested risk factors, though their results do not establish causality. Pesticide exposure has been associated with increased risk in many studies. Other proposed risks include rural residence and certain occupations. Cigarette smoking, use of coffee/caffeine, and non-steroidal antiinflammatory drugs (NSAIDs) all appear to lower risk of PD, while dietary lipid and milk consumption, high caloric intake, and head trauma may increase risk. The cause of PD is likely multifactorial. Underlying genetic susceptibility and combinations of risk and protective factors likely all contribute. The combined research effort by epidemiologists, geneticists, and basic scientists will be needed to clarify the cause(s) of PD.

Authors+Show Affiliations

Department of Clinical Research, Parkinson's Institute, Sunnyvale, CA 94089-1605, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17017522

Citation

Chade, A R., et al. "Nongenetic Causes of Parkinson's Disease." Journal of Neural Transmission. Supplementum, 2006, pp. 147-51.
Chade AR, Kasten M, Tanner CM. Nongenetic causes of Parkinson's disease. J Neural Transm Suppl. 2006.
Chade, A. R., Kasten, M., & Tanner, C. M. (2006). Nongenetic causes of Parkinson's disease. Journal of Neural Transmission. Supplementum, (70), pp. 147-51.
Chade AR, Kasten M, Tanner CM. Nongenetic Causes of Parkinson's Disease. J Neural Transm Suppl. 2006;(70)147-51. PubMed PMID: 17017522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nongenetic causes of Parkinson's disease. AU - Chade,A R, AU - Kasten,M, AU - Tanner,C M, PY - 2006/10/5/pubmed PY - 2006/10/25/medline PY - 2006/10/5/entrez SP - 147 EP - 51 JF - Journal of neural transmission. Supplementum JO - J. Neural Transm. Suppl. IS - 70 N2 - Study of the nongenetic causes of Parkinson's disease (PD) was encouraged by discovery of a cluster of parkinsonism produced by neurotoxic pyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the 1980s. Since that time, epidemiologic investigations have suggested risk factors, though their results do not establish causality. Pesticide exposure has been associated with increased risk in many studies. Other proposed risks include rural residence and certain occupations. Cigarette smoking, use of coffee/caffeine, and non-steroidal antiinflammatory drugs (NSAIDs) all appear to lower risk of PD, while dietary lipid and milk consumption, high caloric intake, and head trauma may increase risk. The cause of PD is likely multifactorial. Underlying genetic susceptibility and combinations of risk and protective factors likely all contribute. The combined research effort by epidemiologists, geneticists, and basic scientists will be needed to clarify the cause(s) of PD. SN - 0303-6995 UR - https://www.unboundmedicine.com/medline/citation/17017522/Nongenetic_causes_of_Parkinson's_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -