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Parkinson's disease dementia: what's in a Lewy body?

Abstract

This brief review deals with pathological aspects of dementia associated with Parkinson's disease (PDD). PDD has been variably linked with cortical Lewy body topography and density. alpha-Synuclein and Alzheimer-type pathology frequently co-exist, suggesting that a combination of pathology related to protein dysmetabolism, possibly with synergistic protein-protein interaction, underpins the cognitive impairment in PDD. Dementia may therefore ensue when a "toxic threshold" is reached, irrespective of the combination of pathologies involved in reaching that threshold. The nature of this putative protein-protein interaction needs to be further elucidated, and also whether there are specific clinical correlates of the pathological substrate. Serum and cerebrospinal fluid proteins or imaging techniques may be useful in future as biomarkers to identify the relative contribution of Lewy-related and Alzheimer-type pathology in a given case of PDD and to inform the rational use of drugs that can reduce alpha-synuclein aggregation and beta-amyloid production.

Authors+Show Affiliations

Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, University of Newcastle upon Tyne, United Kingdom. d.j.burn@ncl.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17017554

Citation

Burn, D J.. "Parkinson's Disease Dementia: What's in a Lewy Body?" Journal of Neural Transmission. Supplementum, 2006, pp. 361-5.
Burn DJ. Parkinson's disease dementia: what's in a Lewy body? J Neural Transm Suppl. 2006.
Burn, D. J. (2006). Parkinson's disease dementia: what's in a Lewy body? Journal of Neural Transmission. Supplementum, (70), 361-5.
Burn DJ. Parkinson's Disease Dementia: What's in a Lewy Body. J Neural Transm Suppl. 2006;(70)361-5. PubMed PMID: 17017554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease dementia: what's in a Lewy body? A1 - Burn,D J, PY - 2006/10/5/pubmed PY - 2006/10/25/medline PY - 2006/10/5/entrez SP - 361 EP - 5 JF - Journal of neural transmission. Supplementum JO - J Neural Transm Suppl IS - 70 N2 - This brief review deals with pathological aspects of dementia associated with Parkinson's disease (PDD). PDD has been variably linked with cortical Lewy body topography and density. alpha-Synuclein and Alzheimer-type pathology frequently co-exist, suggesting that a combination of pathology related to protein dysmetabolism, possibly with synergistic protein-protein interaction, underpins the cognitive impairment in PDD. Dementia may therefore ensue when a "toxic threshold" is reached, irrespective of the combination of pathologies involved in reaching that threshold. The nature of this putative protein-protein interaction needs to be further elucidated, and also whether there are specific clinical correlates of the pathological substrate. Serum and cerebrospinal fluid proteins or imaging techniques may be useful in future as biomarkers to identify the relative contribution of Lewy-related and Alzheimer-type pathology in a given case of PDD and to inform the rational use of drugs that can reduce alpha-synuclein aggregation and beta-amyloid production. SN - 0303-6995 UR - https://www.unboundmedicine.com/medline/citation/17017554/Parkinson's_disease_dementia:_what's_in_a_Lewy_body L2 - http://www.diseaseinfosearch.org/result/4215 DB - PRIME DP - Unbound Medicine ER -
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