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Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors.
J Neurochem. 2006 Nov; 99(4):1311-9.JN

Abstract

Central serotonin2C receptors (5-HT(2C)Rs) control the mesoaccumbens dopamine (DA) pathway. This control involves the constitutive activity (CA) of 5-HT(2C)Rs, and is thought to engage regionally distinct populations of 5-HT(2C)Rs, leading to opposite functional effects. Here, using in vivo microdialysis in halothane-anesthetized rats, we investigated the relative contribution of ventral tegmental area (VTA) and nucleus accumbens shell (NAc) 5-HT(2C)Rs in the phasic/tonic control of accumbal DA release, to specifically identify the nature (inhibition/excitation) of the control, and the role of the 5-HT(2C)R CA. Intra-VTA injections of the selective 5-HT(2C)R antagonists SB 242084 and/or SB 243213 (0.1-0.5 microg/0.2 microL) prevented the decrease in accumbal DA outflow induced by the 5-HT(2C)R agonist Ro 60-0175 (3 mg/kg, i.p), but did not affect the increase in DA outflow induced by the 5-HT(2C)R inverse agonist SB 206553 (5 mg/kg, i.p). Intra-NAc infusions of SB 242084 (0.1-1 microM) blocked Ro 60-0175- and SB 206553-induced changes of DA outflow. Intra-NAc, but not intra-VTA administration of SB 206553 increased basal DA outflow. These findings demonstrate that both VTA and NAc 5-HT(2C)Rs participate in the inhibitory control exerted by 5-HT(2C)Rs on accumbal DA release, and that the NAc shell may represent a primary action site for the CA of 5-HT(2C)Rs.

Authors+Show Affiliations

Unité Mixte de Recherche-Centre National de la Recherche Scientifique (UMR-CNRS 5541), Université Victor Segalen Bordeaux 2, 146 rue Léo Saignât, Boîte Postale 31, 33076 Bordeaux Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17018023

Citation

Navailles, Sylvia, et al. "Region-dependent Regulation of Mesoaccumbens Dopamine Neurons in Vivo By the Constitutive Activity of Central serotonin2C Receptors." Journal of Neurochemistry, vol. 99, no. 4, 2006, pp. 1311-9.
Navailles S, Moison D, Ryczko D, et al. Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. J Neurochem. 2006;99(4):1311-9.
Navailles, S., Moison, D., Ryczko, D., & Spampinato, U. (2006). Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. Journal of Neurochemistry, 99(4), 1311-9.
Navailles S, et al. Region-dependent Regulation of Mesoaccumbens Dopamine Neurons in Vivo By the Constitutive Activity of Central serotonin2C Receptors. J Neurochem. 2006;99(4):1311-9. PubMed PMID: 17018023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. AU - Navailles,Sylvia, AU - Moison,Delphine, AU - Ryczko,Dimitri, AU - Spampinato,Umberto, Y1 - 2006/10/02/ PY - 2006/10/5/pubmed PY - 2007/1/11/medline PY - 2006/10/5/entrez SP - 1311 EP - 9 JF - Journal of neurochemistry JO - J. Neurochem. VL - 99 IS - 4 N2 - Central serotonin2C receptors (5-HT(2C)Rs) control the mesoaccumbens dopamine (DA) pathway. This control involves the constitutive activity (CA) of 5-HT(2C)Rs, and is thought to engage regionally distinct populations of 5-HT(2C)Rs, leading to opposite functional effects. Here, using in vivo microdialysis in halothane-anesthetized rats, we investigated the relative contribution of ventral tegmental area (VTA) and nucleus accumbens shell (NAc) 5-HT(2C)Rs in the phasic/tonic control of accumbal DA release, to specifically identify the nature (inhibition/excitation) of the control, and the role of the 5-HT(2C)R CA. Intra-VTA injections of the selective 5-HT(2C)R antagonists SB 242084 and/or SB 243213 (0.1-0.5 microg/0.2 microL) prevented the decrease in accumbal DA outflow induced by the 5-HT(2C)R agonist Ro 60-0175 (3 mg/kg, i.p), but did not affect the increase in DA outflow induced by the 5-HT(2C)R inverse agonist SB 206553 (5 mg/kg, i.p). Intra-NAc infusions of SB 242084 (0.1-1 microM) blocked Ro 60-0175- and SB 206553-induced changes of DA outflow. Intra-NAc, but not intra-VTA administration of SB 206553 increased basal DA outflow. These findings demonstrate that both VTA and NAc 5-HT(2C)Rs participate in the inhibitory control exerted by 5-HT(2C)Rs on accumbal DA release, and that the NAc shell may represent a primary action site for the CA of 5-HT(2C)Rs. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/17018023/Region_dependent_regulation_of_mesoaccumbens_dopamine_neurons_in_vivo_by_the_constitutive_activity_of_central_serotonin2C_receptors_ L2 - https://doi.org/10.1111/j.1471-4159.2006.04188.x DB - PRIME DP - Unbound Medicine ER -