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3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease.
Brain 2006; 129(Pt 11):2867-73B

Abstract

Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the left [corrected] (right [corrected] P = 0.0024, left [corrected] P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool.

Authors+Show Affiliations

Department of Neurology, David Geffen School of Medicine UCLA, CA, USA. lapostolova@mednet.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17018552

Citation

Apostolova, Liana G., et al. "3D Comparison of Hippocampal Atrophy in Amnestic Mild Cognitive Impairment and Alzheimer's Disease." Brain : a Journal of Neurology, vol. 129, no. Pt 11, 2006, pp. 2867-73.
Apostolova LG, Dinov ID, Dutton RA, et al. 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. Brain. 2006;129(Pt 11):2867-73.
Apostolova, L. G., Dinov, I. D., Dutton, R. A., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006). 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. Brain : a Journal of Neurology, 129(Pt 11), pp. 2867-73.
Apostolova LG, et al. 3D Comparison of Hippocampal Atrophy in Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Brain. 2006;129(Pt 11):2867-73. PubMed PMID: 17018552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. AU - Apostolova,Liana G, AU - Dinov,Ivo D, AU - Dutton,Rebecca A, AU - Hayashi,Kiralee M, AU - Toga,Arthur W, AU - Cummings,Jeffrey L, AU - Thompson,Paul M, Y1 - 2006/10/03/ PY - 2006/10/5/pubmed PY - 2006/12/12/medline PY - 2006/10/5/entrez SP - 2867 EP - 73 JF - Brain : a journal of neurology JO - Brain VL - 129 IS - Pt 11 N2 - Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the left [corrected] (right [corrected] P = 0.0024, left [corrected] P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/17018552/3D_comparison_of_hippocampal_atrophy_in_amnestic_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl274 DB - PRIME DP - Unbound Medicine ER -