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3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease.

Abstract

Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the left [corrected] (right [corrected] P = 0.0024, left [corrected] P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, David Geffen School of Medicine UCLA, CA, USA. lapostolova@mednet.ucla.edu

    , , , , ,

    Source

    Brain : a journal of neurology 129:Pt 11 2006 Nov pg 2867-73

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Atrophy
    Brain Mapping
    Cognition Disorders
    Disease Progression
    Female
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Imaging, Three-Dimensional
    Logistic Models
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Neuropsychological Tests
    Psychiatric Status Rating Scales

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    17018552

    Citation

    Apostolova, Liana G., et al. "3D Comparison of Hippocampal Atrophy in Amnestic Mild Cognitive Impairment and Alzheimer's Disease." Brain : a Journal of Neurology, vol. 129, no. Pt 11, 2006, pp. 2867-73.
    Apostolova LG, Dinov ID, Dutton RA, et al. 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. Brain. 2006;129(Pt 11):2867-73.
    Apostolova, L. G., Dinov, I. D., Dutton, R. A., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006). 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. Brain : a Journal of Neurology, 129(Pt 11), pp. 2867-73.
    Apostolova LG, et al. 3D Comparison of Hippocampal Atrophy in Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Brain. 2006;129(Pt 11):2867-73. PubMed PMID: 17018552.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. AU - Apostolova,Liana G, AU - Dinov,Ivo D, AU - Dutton,Rebecca A, AU - Hayashi,Kiralee M, AU - Toga,Arthur W, AU - Cummings,Jeffrey L, AU - Thompson,Paul M, Y1 - 2006/10/03/ PY - 2006/10/5/pubmed PY - 2006/12/12/medline PY - 2006/10/5/entrez SP - 2867 EP - 73 JF - Brain : a journal of neurology JO - Brain VL - 129 IS - Pt 11 N2 - Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the left [corrected] (right [corrected] P = 0.0024, left [corrected] P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/17018552/3D_comparison_of_hippocampal_atrophy_in_amnestic_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl274 DB - PRIME DP - Unbound Medicine ER -