Tags

Type your tag names separated by a space and hit enter

Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women.

Abstract

BACKGROUND

Higher levels of endogenous sex steroid hormones are associated with increased risks of breast cancer in postmenopausal women. Data for premenopausal women are sparse, in part because of the complexity of measuring hormone levels that vary cyclically. We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II.

METHODS

From 1996 to 1999, blood samples were collected from 18,521 premenopausal women during the early follicular and midluteal phases of their menstrual cycles. A total of 197 cases of breast cancer were diagnosed among these women after blood collection and before June 1, 2003; these case subjects were matched to 394 control subjects. Logistic regression models, controlling for breast cancer risk factors, were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). All statistical tests were two-sided.

RESULTS

Women in the highest (versus the lowest) quartiles of follicular total and free estradiol levels had statistically significantly increased risks of breast cancer (RR = 2.1 [95% CI = 1.1 to 4.1], P(trend) = .08, and RR = 2.4 [95% CI = 1.3 to 4.5], P(trend) = .01, respectively); the associations were stronger for invasive breast cancer and for estrogen and progesterone receptor-positive (ER+/PR+) tumors. Luteal estradiol levels were not associated with breast cancer risk. Higher levels of total and free testosterone and androstenedione in both menstrual cycle phases were associated with modest, non-statistically significant increases in overall risk of breast cancer and with stronger, statistically significant increases in risks of invasive and ER+/PR+ cancers (e.g., RR of invasive cancers for the top [versus bottom] quartile of luteal total testosterone levels = 2.0 [95% CI = 1.1 to 3.6], P(trend) = .05, and RR of ER+/PR+ cancers = 2.9 [95% CI = 1.4 to 6.0], P(trend) = .02). Levels of estrone, estrone sulfate, progesterone, and sex hormone-binding globulin were not associated with breast cancer risk. The absolute number of cases observed over 3 years were 30 among women in the lowest 25% of follicular total estradiol levels and 50 among women in the highest 25%.

CONCLUSIONS

Levels of circulating estrogens and androgens may be important in the etiology of premenopausal breast cancer.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115, USA. heather.eliassen@channing.harvard.edu

    , , , , ,

    Source

    Journal of the National Cancer Institute 98:19 2006 Oct 04 pg 1406-15

    MeSH

    Adult
    Androgens
    Breast Neoplasms
    Case-Control Studies
    Estradiol
    Estrogens
    Female
    Gonadal Steroid Hormones
    Humans
    Logistic Models
    Nurses
    Odds Ratio
    Ovarian Follicle
    Premenopause
    Prospective Studies
    Risk Assessment
    Risk Factors
    Sex Hormone-Binding Globulin
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17018787

    Citation

    Eliassen, A Heather, et al. "Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women." Journal of the National Cancer Institute, vol. 98, no. 19, 2006, pp. 1406-15.
    Eliassen AH, Missmer SA, Tworoger SS, et al. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst. 2006;98(19):1406-15.
    Eliassen, A. H., Missmer, S. A., Tworoger, S. S., Spiegelman, D., Barbieri, R. L., Dowsett, M., & Hankinson, S. E. (2006). Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. Journal of the National Cancer Institute, 98(19), pp. 1406-15.
    Eliassen AH, et al. Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women. J Natl Cancer Inst. 2006 Oct 4;98(19):1406-15. PubMed PMID: 17018787.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. AU - Eliassen,A Heather, AU - Missmer,Stacey A, AU - Tworoger,Shelley S, AU - Spiegelman,Donna, AU - Barbieri,Robert L, AU - Dowsett,Mitch, AU - Hankinson,Susan E, PY - 2006/10/5/pubmed PY - 2006/10/13/medline PY - 2006/10/5/entrez SP - 1406 EP - 15 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 98 IS - 19 N2 - BACKGROUND: Higher levels of endogenous sex steroid hormones are associated with increased risks of breast cancer in postmenopausal women. Data for premenopausal women are sparse, in part because of the complexity of measuring hormone levels that vary cyclically. We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II. METHODS: From 1996 to 1999, blood samples were collected from 18,521 premenopausal women during the early follicular and midluteal phases of their menstrual cycles. A total of 197 cases of breast cancer were diagnosed among these women after blood collection and before June 1, 2003; these case subjects were matched to 394 control subjects. Logistic regression models, controlling for breast cancer risk factors, were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS: Women in the highest (versus the lowest) quartiles of follicular total and free estradiol levels had statistically significantly increased risks of breast cancer (RR = 2.1 [95% CI = 1.1 to 4.1], P(trend) = .08, and RR = 2.4 [95% CI = 1.3 to 4.5], P(trend) = .01, respectively); the associations were stronger for invasive breast cancer and for estrogen and progesterone receptor-positive (ER+/PR+) tumors. Luteal estradiol levels were not associated with breast cancer risk. Higher levels of total and free testosterone and androstenedione in both menstrual cycle phases were associated with modest, non-statistically significant increases in overall risk of breast cancer and with stronger, statistically significant increases in risks of invasive and ER+/PR+ cancers (e.g., RR of invasive cancers for the top [versus bottom] quartile of luteal total testosterone levels = 2.0 [95% CI = 1.1 to 3.6], P(trend) = .05, and RR of ER+/PR+ cancers = 2.9 [95% CI = 1.4 to 6.0], P(trend) = .02). Levels of estrone, estrone sulfate, progesterone, and sex hormone-binding globulin were not associated with breast cancer risk. The absolute number of cases observed over 3 years were 30 among women in the lowest 25% of follicular total estradiol levels and 50 among women in the highest 25%. CONCLUSIONS: Levels of circulating estrogens and androgens may be important in the etiology of premenopausal breast cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/17018787/Endogenous_steroid_hormone_concentrations_and_risk_of_breast_cancer_among_premenopausal_women_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djj376 DB - PRIME DP - Unbound Medicine ER -