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Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women.
Menopause. 2007 Jan-Feb; 14(1):106-14.M

Abstract

OBJECTIVE

Some clinical trials have demonstrated a beneficial effect of dietary soy protein on improving lipoproteins. Research also has documented that serum lipoproteins and some lipoprotein subclasses are altered as a consequence of menopause, resulting in a more atherogenic lipid profile. The purpose of this study was to determine the effects of isolated soy protein-containing isoflavones on lipoproteins and lipoprotein subclasses in both African American and white postmenopausal women with borderline to moderate low-density lipoprotein cholesterol elevations.

DESIGN

This was a randomized, double-blind, controlled clinical trial including 216 postmenopausal women. After a 4-week run-in period with a casein protein-based supplement, participants were randomly assigned to continue the casein placebo or receive soy protein-containing isoflavones for a period of 12 weeks.

RESULTS

In the soy group, the total cholesterol, low-density lipoprotein cholesterol, and low-density lipoprotein particle number decreased significantly as compared with the placebo group at 6 weeks. Although this decrease continued at 12 weeks in the soy group, the difference from the placebo group was attenuated for total cholesterol and low-density lipoprotein particle number. Multivariate analyses controlling for age, race, change in weight, change in dietary fat intake, and change in kilocalorie energy expenditure revealed that treatment remained a significant independent predictor of change in total cholesterol (P = 0.01), low-density lipoprotein cholesterol (P = 0.02), and low-density lipoprotein particle number (P = 0.002) after 6 weeks of dietary soy.

CONCLUSIONS

Increased consumption of soy protein replacing animal protein that is high in fat may help improve atherogenic lipid profiles.

Authors+Show Affiliations

Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA. jallen@son.jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17019375

Citation

Allen, Jerilyn K., et al. "Effect of Soy Protein-containing Isoflavones On Lipoproteins in Postmenopausal Women." Menopause (New York, N.Y.), vol. 14, no. 1, 2007, pp. 106-14.
Allen JK, Becker DM, Kwiterovich PO, et al. Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women. Menopause. 2007;14(1):106-14.
Allen, J. K., Becker, D. M., Kwiterovich, P. O., Lindenstruth, K. A., & Curtis, C. (2007). Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women. Menopause (New York, N.Y.), 14(1), 106-14.
Allen JK, et al. Effect of Soy Protein-containing Isoflavones On Lipoproteins in Postmenopausal Women. Menopause. 2007 Jan-Feb;14(1):106-14. PubMed PMID: 17019375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women. AU - Allen,Jerilyn K, AU - Becker,Diane M, AU - Kwiterovich,Peter O, AU - Lindenstruth,Kathleen A, AU - Curtis,Carol, PY - 2006/10/5/pubmed PY - 2007/4/27/medline PY - 2006/10/5/entrez SP - 106 EP - 14 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 1 N2 - OBJECTIVE: Some clinical trials have demonstrated a beneficial effect of dietary soy protein on improving lipoproteins. Research also has documented that serum lipoproteins and some lipoprotein subclasses are altered as a consequence of menopause, resulting in a more atherogenic lipid profile. The purpose of this study was to determine the effects of isolated soy protein-containing isoflavones on lipoproteins and lipoprotein subclasses in both African American and white postmenopausal women with borderline to moderate low-density lipoprotein cholesterol elevations. DESIGN: This was a randomized, double-blind, controlled clinical trial including 216 postmenopausal women. After a 4-week run-in period with a casein protein-based supplement, participants were randomly assigned to continue the casein placebo or receive soy protein-containing isoflavones for a period of 12 weeks. RESULTS: In the soy group, the total cholesterol, low-density lipoprotein cholesterol, and low-density lipoprotein particle number decreased significantly as compared with the placebo group at 6 weeks. Although this decrease continued at 12 weeks in the soy group, the difference from the placebo group was attenuated for total cholesterol and low-density lipoprotein particle number. Multivariate analyses controlling for age, race, change in weight, change in dietary fat intake, and change in kilocalorie energy expenditure revealed that treatment remained a significant independent predictor of change in total cholesterol (P = 0.01), low-density lipoprotein cholesterol (P = 0.02), and low-density lipoprotein particle number (P = 0.002) after 6 weeks of dietary soy. CONCLUSIONS: Increased consumption of soy protein replacing animal protein that is high in fat may help improve atherogenic lipid profiles. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17019375/Effect_of_soy_protein_containing_isoflavones_on_lipoproteins_in_postmenopausal_women_ L2 - https://doi.org/10.1097/01.gme.0000229572.21635.49 DB - PRIME DP - Unbound Medicine ER -