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Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women.
Menopause 2006 Nov-Dec; 13(6):942-50M

Abstract

OBJECTIVE

To evaluate the effects of soy germ isoflavones and hormone therapy on vascular reactivity, the formation of nitric oxide derivatives, and lipid peroxidation in hypercholesterolemic postmenopausal women.

DESIGN

Women were treated with soy germ, 17beta-estradiol or 17beta-estradiol + noretisterone acetate for 3 months after taking placebo for 1 month. The plasma concentrations of nitrite + nitrate and S-nitrosothiols were evaluated by gaseous phase chemiluminescence; nitrotyrosine, electronegative low-density lipoprotein, and estradiol levels were determined by enzyme-linked immunosorbent assay; cholesterol oxides and isoflavones were determined by gas chromatography and high-performance liquid chromatography, respectively. Vascular reactivity was analyzed by high-resolution ultrasonography.

RESULTS

Soy germ isoflavones and hormone therapy induced a decrease in nitrite + nitrate, electronegative low-density lipoprotein, and cholesterol oxides, as well as an increase in S-nitrosothiols. Soy germ isoflavones lowered electronegative low-density lipoprotein, and cholesterol oxides more efficiently than did hormone therapy. Only soy isoflavones inhibited nitrotyrosine formation. A significant improvement of vascular reactivity was only seen in women treated with 17beta-estradiol.

CONCLUSIONS

The soy germ isoflavones and 17beta-estradiol, alone or associated with noretisterone acetate, in the doses and forms used here, have similar effects on the bioavailability of nitric oxide. Soy germ treatment inhibited lipid peroxidation more effectively than hormone therapy.

Authors+Show Affiliations

School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17019381

Citation

Pereira, Isabela R O., et al. "Effects of Soy Germ Isoflavones and Hormone Therapy On Nitric Oxide Derivatives, Low-density Lipoprotein Oxidation, and Vascular Reactivity in Hypercholesterolemic Postmenopausal Women." Menopause (New York, N.Y.), vol. 13, no. 6, 2006, pp. 942-50.
Pereira IR, Faludi AA, Aldrighi JM, et al. Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. Menopause. 2006;13(6):942-50.
Pereira, I. R., Faludi, A. A., Aldrighi, J. M., Bertolami, M. C., Saleh, M. H., Silva, R. A., ... Abdalla, D. S. (2006). Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. Menopause (New York, N.Y.), 13(6), pp. 942-50.
Pereira IR, et al. Effects of Soy Germ Isoflavones and Hormone Therapy On Nitric Oxide Derivatives, Low-density Lipoprotein Oxidation, and Vascular Reactivity in Hypercholesterolemic Postmenopausal Women. Menopause. 2006;13(6):942-50. PubMed PMID: 17019381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. AU - Pereira,Isabela R O, AU - Faludi,André Arpad, AU - Aldrighi,José Mendes, AU - Bertolami,Marcelo Chiara, AU - Saleh,Mohamed H, AU - Silva,Renata Alves, AU - Nakamura,Yara, AU - Campos,Maria Fernanda, AU - Novaes,Nadjara, AU - Abdalla,Dulcineia Saes Parra, PY - 2006/10/5/pubmed PY - 2007/2/9/medline PY - 2006/10/5/entrez SP - 942 EP - 50 JF - Menopause (New York, N.Y.) JO - Menopause VL - 13 IS - 6 N2 - OBJECTIVE: To evaluate the effects of soy germ isoflavones and hormone therapy on vascular reactivity, the formation of nitric oxide derivatives, and lipid peroxidation in hypercholesterolemic postmenopausal women. DESIGN: Women were treated with soy germ, 17beta-estradiol or 17beta-estradiol + noretisterone acetate for 3 months after taking placebo for 1 month. The plasma concentrations of nitrite + nitrate and S-nitrosothiols were evaluated by gaseous phase chemiluminescence; nitrotyrosine, electronegative low-density lipoprotein, and estradiol levels were determined by enzyme-linked immunosorbent assay; cholesterol oxides and isoflavones were determined by gas chromatography and high-performance liquid chromatography, respectively. Vascular reactivity was analyzed by high-resolution ultrasonography. RESULTS: Soy germ isoflavones and hormone therapy induced a decrease in nitrite + nitrate, electronegative low-density lipoprotein, and cholesterol oxides, as well as an increase in S-nitrosothiols. Soy germ isoflavones lowered electronegative low-density lipoprotein, and cholesterol oxides more efficiently than did hormone therapy. Only soy isoflavones inhibited nitrotyrosine formation. A significant improvement of vascular reactivity was only seen in women treated with 17beta-estradiol. CONCLUSIONS: The soy germ isoflavones and 17beta-estradiol, alone or associated with noretisterone acetate, in the doses and forms used here, have similar effects on the bioavailability of nitric oxide. Soy germ treatment inhibited lipid peroxidation more effectively than hormone therapy. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17019381/Effects_of_soy_germ_isoflavones_and_hormone_therapy_on_nitric_oxide_derivatives_low_density_lipoprotein_oxidation_and_vascular_reactivity_in_hypercholesterolemic_postmenopausal_women_ L2 - http://Insights.ovid.com/pubmed?pmid=17019381 DB - PRIME DP - Unbound Medicine ER -