Tags

Type your tag names separated by a space and hit enter

Catha edulis extract and its active principle cathinone induce ipsilateral rotation in unilaterally lesioned rats.
Behav Pharmacol. 2006 Nov; 17(7):615-20.BP

Abstract

Catha edulis extract, a natural psychostimulant, and its active component, S-(-)-cathinone, were evaluated for their rotational effects in unilaterally lesioned rats. In our earlier study, we demonstrated that commercially available S-(-)-cathinone, the active principle of C. edulis extract, reverses haloperidol-induced catalepsy. In the current study, we evaluated the effect of C. edulis extract or its active principle, cathinone, in 6-hydroxydopamine unilaterally lesioned rats. Evaluation of the rotational behaviour induced by this natural psychostimulant was made upon acute and repeated oral administration. The data show that C. edulis extract or S-(-)-cathinone induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats. The ipsilateral rotation produced by commercially available S-(-)-cathinone was more marked than the response produced by oral administration of lyophilized C. edulis extract at the dose and periods specified. In addition, upon repeated administration, the effect was more pronounced (i.e. there was sensitization). In conclusion, the results demonstrate that the plant induces ipsilateral rotation, like its close relative amphetamine.

Authors+Show Affiliations

Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Tuebingen, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17021394

Citation

Banjaw, Mehret Yerdaw, and Werner J. Schmidt. "Catha Edulis Extract and Its Active Principle Cathinone Induce Ipsilateral Rotation in Unilaterally Lesioned Rats." Behavioural Pharmacology, vol. 17, no. 7, 2006, pp. 615-20.
Banjaw MY, Schmidt WJ. Catha edulis extract and its active principle cathinone induce ipsilateral rotation in unilaterally lesioned rats. Behav Pharmacol. 2006;17(7):615-20.
Banjaw, M. Y., & Schmidt, W. J. (2006). Catha edulis extract and its active principle cathinone induce ipsilateral rotation in unilaterally lesioned rats. Behavioural Pharmacology, 17(7), 615-20.
Banjaw MY, Schmidt WJ. Catha Edulis Extract and Its Active Principle Cathinone Induce Ipsilateral Rotation in Unilaterally Lesioned Rats. Behav Pharmacol. 2006;17(7):615-20. PubMed PMID: 17021394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Catha edulis extract and its active principle cathinone induce ipsilateral rotation in unilaterally lesioned rats. AU - Banjaw,Mehret Yerdaw, AU - Schmidt,Werner J, PY - 2006/10/6/pubmed PY - 2006/12/9/medline PY - 2006/10/6/entrez SP - 615 EP - 20 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 17 IS - 7 N2 - Catha edulis extract, a natural psychostimulant, and its active component, S-(-)-cathinone, were evaluated for their rotational effects in unilaterally lesioned rats. In our earlier study, we demonstrated that commercially available S-(-)-cathinone, the active principle of C. edulis extract, reverses haloperidol-induced catalepsy. In the current study, we evaluated the effect of C. edulis extract or its active principle, cathinone, in 6-hydroxydopamine unilaterally lesioned rats. Evaluation of the rotational behaviour induced by this natural psychostimulant was made upon acute and repeated oral administration. The data show that C. edulis extract or S-(-)-cathinone induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats. The ipsilateral rotation produced by commercially available S-(-)-cathinone was more marked than the response produced by oral administration of lyophilized C. edulis extract at the dose and periods specified. In addition, upon repeated administration, the effect was more pronounced (i.e. there was sensitization). In conclusion, the results demonstrate that the plant induces ipsilateral rotation, like its close relative amphetamine. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/17021394/Catha_edulis_extract_and_its_active_principle_cathinone_induce_ipsilateral_rotation_in_unilaterally_lesioned_rats_ L2 - http://dx.doi.org/10.1097/01.fbp.0000236273.10418.2b DB - PRIME DP - Unbound Medicine ER -