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Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.
Eur J Pharmacol. 2006 Nov 21; 550(1-3):117-22.EJ

Abstract

The present study investigated the involvement of 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization in mice. THC (10 mg/kg, i.p.) induced catalepsy-like immobilization but had no effect on motor coordination in the rota-rod test. The selective cannabinoid CB(1) receptor antagonist rimonabant (3 mg/kg, i.p.) completely antagonized THC-induced catalepsy-like immobilization. The 5-HT(1A)/5-HT(7) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT; 0.3 and 1 mg/kg, i.p.) and 5-HT(1A) receptor partial agonist buspirone (0.06 and 0.1 mg/kg, i.p.) inhibited this THC-induced catalepsy-like immobilization. Moreover, the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohezane carboxamide dihydrochloride (WAY100635; 0.3 or 1 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization by 8-OH-DPAT (1 mg/kg) or buspirone (0.06 mg/kg). In contrast, the selective 5-HT(7) receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this inhibitory effect of 8-OH-DPAT. On the other hand, WAY100635 (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced catalepsy-like immobilization.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka, University, 8-19-1, Nanakuma, Fukuoka 814-0180, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17022969

Citation

Egashira, Nobuaki, et al. "Involvement of 5-hydroxytryptamine1A Receptors in Delta9-tetrahydrocannabinol-induced Catalepsy-like Immobilization in Mice." European Journal of Pharmacology, vol. 550, no. 1-3, 2006, pp. 117-22.
Egashira N, Matsuda T, Koushi E, et al. Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. Eur J Pharmacol. 2006;550(1-3):117-22.
Egashira, N., Matsuda, T., Koushi, E., Mishima, K., Iwasaki, K., Shoyama, Y., & Fujiwara, M. (2006). Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. European Journal of Pharmacology, 550(1-3), 117-22.
Egashira N, et al. Involvement of 5-hydroxytryptamine1A Receptors in Delta9-tetrahydrocannabinol-induced Catalepsy-like Immobilization in Mice. Eur J Pharmacol. 2006 Nov 21;550(1-3):117-22. PubMed PMID: 17022969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. AU - Egashira,Nobuaki, AU - Matsuda,Tomomi, AU - Koushi,Emi, AU - Mishima,Kenichi, AU - Iwasaki,Katsunori, AU - Shoyama,Yukihiro, AU - Fujiwara,Michihiro, Y1 - 2006/09/06/ PY - 2006/03/16/received PY - 2006/08/24/revised PY - 2006/08/28/accepted PY - 2006/10/7/pubmed PY - 2006/12/16/medline PY - 2006/10/7/entrez SP - 117 EP - 22 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 550 IS - 1-3 N2 - The present study investigated the involvement of 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization in mice. THC (10 mg/kg, i.p.) induced catalepsy-like immobilization but had no effect on motor coordination in the rota-rod test. The selective cannabinoid CB(1) receptor antagonist rimonabant (3 mg/kg, i.p.) completely antagonized THC-induced catalepsy-like immobilization. The 5-HT(1A)/5-HT(7) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT; 0.3 and 1 mg/kg, i.p.) and 5-HT(1A) receptor partial agonist buspirone (0.06 and 0.1 mg/kg, i.p.) inhibited this THC-induced catalepsy-like immobilization. Moreover, the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohezane carboxamide dihydrochloride (WAY100635; 0.3 or 1 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization by 8-OH-DPAT (1 mg/kg) or buspirone (0.06 mg/kg). In contrast, the selective 5-HT(7) receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this inhibitory effect of 8-OH-DPAT. On the other hand, WAY100635 (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced catalepsy-like immobilization. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17022969/Involvement_of_5_hydroxytryptamine1A_receptors_in_Delta9_tetrahydrocannabinol_induced_catalepsy_like_immobilization_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)00938-1 DB - PRIME DP - Unbound Medicine ER -