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Afferent synapses are present in utricular hair cells from otoconia-deficient mice.
Hear Res 2006; 222(1-2):35-42HR

Abstract

The head tilt mouse (het/het, abbr. het) is a naturally occurring mutant whose salient phenotypic traits include the complete absence of otoconia in both the utricle and saccule. Cursory histologic evaluation has indicated that the neuroepithelia exhibit a normal appearance. Though evidence exists indicating that utricular function is severely if not completely compromised in these animals, it is not yet known whether afferent synapses exist within utricular hair cells of otoconia-deficient mutants. The absence of synapses would be suggestive of a trophic relationship between stimulus-evoked hair cell activation and the afferent synapse. To address this question, we have conducted an ultrastructural survey of utricular sensory epithelia from confirmed het mice. The specific objective was to determine whether utricular hair cells made synaptic contact with afferent neurons. We found that both type I and II hair cells from utricles of het mice exhibited afferent synapses that were found at numerous sites distributed throughout the utricle. These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity.

Authors+Show Affiliations

Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA 90095-1624, USA. lfh@ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17023128

Citation

Hoffman, Larry F., et al. "Afferent Synapses Are Present in Utricular Hair Cells From Otoconia-deficient Mice." Hearing Research, vol. 222, no. 1-2, 2006, pp. 35-42.
Hoffman LF, Ross MD, Varelas J, et al. Afferent synapses are present in utricular hair cells from otoconia-deficient mice. Hear Res. 2006;222(1-2):35-42.
Hoffman, L. F., Ross, M. D., Varelas, J., Jones, S. M., & Jones, T. A. (2006). Afferent synapses are present in utricular hair cells from otoconia-deficient mice. Hearing Research, 222(1-2), pp. 35-42.
Hoffman LF, et al. Afferent Synapses Are Present in Utricular Hair Cells From Otoconia-deficient Mice. Hear Res. 2006;222(1-2):35-42. PubMed PMID: 17023128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Afferent synapses are present in utricular hair cells from otoconia-deficient mice. AU - Hoffman,Larry F, AU - Ross,Muriel D, AU - Varelas,Joseph, AU - Jones,Sherri M, AU - Jones,Timothy A, Y1 - 2006/10/04/ PY - 2005/04/20/received PY - 2006/05/17/revised PY - 2006/05/19/accepted PY - 2006/10/7/pubmed PY - 2007/3/14/medline PY - 2006/10/7/entrez SP - 35 EP - 42 JF - Hearing research JO - Hear. Res. VL - 222 IS - 1-2 N2 - The head tilt mouse (het/het, abbr. het) is a naturally occurring mutant whose salient phenotypic traits include the complete absence of otoconia in both the utricle and saccule. Cursory histologic evaluation has indicated that the neuroepithelia exhibit a normal appearance. Though evidence exists indicating that utricular function is severely if not completely compromised in these animals, it is not yet known whether afferent synapses exist within utricular hair cells of otoconia-deficient mutants. The absence of synapses would be suggestive of a trophic relationship between stimulus-evoked hair cell activation and the afferent synapse. To address this question, we have conducted an ultrastructural survey of utricular sensory epithelia from confirmed het mice. The specific objective was to determine whether utricular hair cells made synaptic contact with afferent neurons. We found that both type I and II hair cells from utricles of het mice exhibited afferent synapses that were found at numerous sites distributed throughout the utricle. These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/17023128/Afferent_synapses_are_present_in_utricular_hair_cells_from_otoconia_deficient_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5955(06)00227-9 DB - PRIME DP - Unbound Medicine ER -