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Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age.
Am J Clin Nutr. 2006 Oct; 84(4):903-11.AJ

Abstract

BACKGROUND

Low intakes of dietary antioxidants may contribute to increases in asthma and allergy.

OBJECTIVE

We investigated the association of maternal total intakes (foods + supplements) of 10 antioxidant nutrients during pregnancy with wheezing and eczema in 2-y-old children.

DESIGN

Subjects were 1290 mother-child pairs in an ongoing cohort study. Maternal dietary and supplement intakes were assessed by using a validated food-frequency questionnaire administered in the first and second trimesters. Antioxidant nutrient intakes were calculated, and the mean for each nutrient was considered to be the exposure during pregnancy. The outcomes of interest were any wheezing by the child during either the first or second year of life, recurrent wheezing in both years, and eczema in either the first or second year.

RESULTS

No association was observed between maternal total intake of any antioxidant nutrient and eczema. In multivariate logistic regression models, the highest quartile compared with the lowest quartile of maternal total intakes of vitamin E [odds ratio (OR): 0.70; 95% CI: 0.48, 1.03] and zinc (OR: 0.59; 95% CI: 0.41, 0.88) was inversely associated with any wheezing at 2 y of age (P for trend = 0.06 and 0.01 over quartiles of intake for vitamin E and zinc, respectively). Similar results were obtained for recurrent wheezing at 2 y of age with vitamin E (OR: 0.49; 95% CI: 0.27, 0.90) and zinc (OR: 0.49; 95% CI: 0.27, 0.87) (P for trend = 0.05 and 0.06 over quartiles of intake for vitamin E and zinc, respectively).

CONCLUSION

Our results suggest that higher maternal total intakes of antioxidants during pregnancy may decrease the risks for wheezing illnesses in early childhood.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. augusto.litonjua@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17023719

Citation

Litonjua, Augusto A., et al. "Maternal Antioxidant Intake in Pregnancy and Wheezing Illnesses in Children at 2 Y of Age." The American Journal of Clinical Nutrition, vol. 84, no. 4, 2006, pp. 903-11.
Litonjua AA, Rifas-Shiman SL, Ly NP, et al. Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr. 2006;84(4):903-11.
Litonjua, A. A., Rifas-Shiman, S. L., Ly, N. P., Tantisira, K. G., Rich-Edwards, J. W., Camargo, C. A., Weiss, S. T., Gillman, M. W., & Gold, D. R. (2006). Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. The American Journal of Clinical Nutrition, 84(4), 903-11.
Litonjua AA, et al. Maternal Antioxidant Intake in Pregnancy and Wheezing Illnesses in Children at 2 Y of Age. Am J Clin Nutr. 2006;84(4):903-11. PubMed PMID: 17023719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. AU - Litonjua,Augusto A, AU - Rifas-Shiman,Sheryl L, AU - Ly,Ngoc P, AU - Tantisira,Kelan G, AU - Rich-Edwards,Janet W, AU - Camargo,Carlos A,Jr AU - Weiss,Scott T, AU - Gillman,Matthew W, AU - Gold,Diane R, PY - 2006/10/7/pubmed PY - 2006/11/2/medline PY - 2006/10/7/entrez SP - 903 EP - 11 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 84 IS - 4 N2 - BACKGROUND: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy. OBJECTIVE: We investigated the association of maternal total intakes (foods + supplements) of 10 antioxidant nutrients during pregnancy with wheezing and eczema in 2-y-old children. DESIGN: Subjects were 1290 mother-child pairs in an ongoing cohort study. Maternal dietary and supplement intakes were assessed by using a validated food-frequency questionnaire administered in the first and second trimesters. Antioxidant nutrient intakes were calculated, and the mean for each nutrient was considered to be the exposure during pregnancy. The outcomes of interest were any wheezing by the child during either the first or second year of life, recurrent wheezing in both years, and eczema in either the first or second year. RESULTS: No association was observed between maternal total intake of any antioxidant nutrient and eczema. In multivariate logistic regression models, the highest quartile compared with the lowest quartile of maternal total intakes of vitamin E [odds ratio (OR): 0.70; 95% CI: 0.48, 1.03] and zinc (OR: 0.59; 95% CI: 0.41, 0.88) was inversely associated with any wheezing at 2 y of age (P for trend = 0.06 and 0.01 over quartiles of intake for vitamin E and zinc, respectively). Similar results were obtained for recurrent wheezing at 2 y of age with vitamin E (OR: 0.49; 95% CI: 0.27, 0.90) and zinc (OR: 0.49; 95% CI: 0.27, 0.87) (P for trend = 0.05 and 0.06 over quartiles of intake for vitamin E and zinc, respectively). CONCLUSION: Our results suggest that higher maternal total intakes of antioxidants during pregnancy may decrease the risks for wheezing illnesses in early childhood. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17023719/Maternal_antioxidant_intake_in_pregnancy_and_wheezing_illnesses_in_children_at_2_y_of_age_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/84.4.903 DB - PRIME DP - Unbound Medicine ER -