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Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier.
J Biomater Sci Polym Ed 2006; 17(8):941-51JB

Abstract

A biodegradable amphiphilic graft polymer was successfully synthesized by grafting hydrophobic poly(1,3-trimethylene carbonate) (PTMC) sequences onto a hydrophilic poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide) (PHEA) backbone. The graft polymer, PHEA-g-PTMC, was synthesized by ring-opening polymerization initiated by the macroinitiator PHEA bearing hydroxyl groups without adding any catalyst. The graft polymer was characterized by Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance spectroscopy, combined size-exclusion chromatography and multiangle laser light scattering analysis. Two drugs with distinct water solubility, prednisone acetate and tegafur, were encapsulated in the PHEA-g-PTMC nanoparticles. The in vitro release of two drugs from PHEA-g-PTMC nanoparticle drug-delivery systems was investigated.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P R. China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17024882

Citation

Peng, Tao, et al. "Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene Carbonate) Amphiphilic Graft Co-polymer as a Potential Drug Carrier." Journal of Biomaterials Science. Polymer Edition, vol. 17, no. 8, 2006, pp. 941-51.
Peng T, Su J, Cheng SX, et al. Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier. J Biomater Sci Polym Ed. 2006;17(8):941-51.
Peng, T., Su, J., Cheng, S. X., & Zhuo, R. X. (2006). Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier. Journal of Biomaterials Science. Polymer Edition, 17(8), pp. 941-51.
Peng T, et al. Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene Carbonate) Amphiphilic Graft Co-polymer as a Potential Drug Carrier. J Biomater Sci Polym Ed. 2006;17(8):941-51. PubMed PMID: 17024882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier. AU - Peng,Tao, AU - Su,Jing, AU - Cheng,Si-Xue, AU - Zhuo,Ren-Xi, PY - 2006/10/10/pubmed PY - 2006/11/10/medline PY - 2006/10/10/entrez SP - 941 EP - 51 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 17 IS - 8 N2 - A biodegradable amphiphilic graft polymer was successfully synthesized by grafting hydrophobic poly(1,3-trimethylene carbonate) (PTMC) sequences onto a hydrophilic poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide) (PHEA) backbone. The graft polymer, PHEA-g-PTMC, was synthesized by ring-opening polymerization initiated by the macroinitiator PHEA bearing hydroxyl groups without adding any catalyst. The graft polymer was characterized by Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance spectroscopy, combined size-exclusion chromatography and multiangle laser light scattering analysis. Two drugs with distinct water solubility, prednisone acetate and tegafur, were encapsulated in the PHEA-g-PTMC nanoparticles. The in vitro release of two drugs from PHEA-g-PTMC nanoparticle drug-delivery systems was investigated. SN - 0920-5063 UR - https://www.unboundmedicine.com/medline/citation/17024882/Poly_alphabeta__N__2_hydroxyethyl__L_aspartamide__g_poly_13trimethylene_carbonate__amphiphilic_graft_co_polymer_as_a_potential_drug_carrier_ L2 - http://www.tandfonline.com/doi/full/10.1163/156856206777996899 DB - PRIME DP - Unbound Medicine ER -