Tags

Type your tag names separated by a space and hit enter

Enhancement of dissolution profile by solid dispersion (kneading) technique.
AAPS PharmSciTech. 2006 Aug 18; 7(3):68.AP

Abstract

This article investigates enhancement of the dissolution profile of valdecoxib using solid dispersion with PVP. The article also describes the preparation of fast-dissolving tablets of valdecoxib by using a high amount of superdisintegrants. A phase solubility method was used to evaluate the effect of various water-soluble polymers on aqueous solubility of valdecoxib. Polyvinyl pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of kneading. Dissolution studies using the USP paddle method were performed for solid dispersions of valdecoxib. Infrared (IR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with commercial products. IR spectroscopy, XRD, and DSC showed no change in the crystal structure of valdecoxib. Dissolution of valdecoxib improved significantly in solid dispersion products (< 85% in 5 minutes). Tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of valdecoxib.

Authors+Show Affiliations

Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17025249

Citation

Modi, Aftab, and Pralhad Tayade. "Enhancement of Dissolution Profile By Solid Dispersion (kneading) Technique." AAPS PharmSciTech, vol. 7, no. 3, 2006, p. 68.
Modi A, Tayade P. Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech. 2006;7(3):68.
Modi, A., & Tayade, P. (2006). Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech, 7(3), 68.
Modi A, Tayade P. Enhancement of Dissolution Profile By Solid Dispersion (kneading) Technique. AAPS PharmSciTech. 2006 Aug 18;7(3):68. PubMed PMID: 17025249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of dissolution profile by solid dispersion (kneading) technique. AU - Modi,Aftab, AU - Tayade,Pralhad, Y1 - 2006/08/18/ PY - 2006/10/10/pubmed PY - 2006/10/17/medline PY - 2006/10/10/entrez SP - 68 EP - 68 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 7 IS - 3 N2 - This article investigates enhancement of the dissolution profile of valdecoxib using solid dispersion with PVP. The article also describes the preparation of fast-dissolving tablets of valdecoxib by using a high amount of superdisintegrants. A phase solubility method was used to evaluate the effect of various water-soluble polymers on aqueous solubility of valdecoxib. Polyvinyl pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of kneading. Dissolution studies using the USP paddle method were performed for solid dispersions of valdecoxib. Infrared (IR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with commercial products. IR spectroscopy, XRD, and DSC showed no change in the crystal structure of valdecoxib. Dissolution of valdecoxib improved significantly in solid dispersion products (< 85% in 5 minutes). Tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of valdecoxib. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/17025249/Enhancement_of_dissolution_profile_by_solid_dispersion__kneading__technique_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17025249/ DB - PRIME DP - Unbound Medicine ER -