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Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl beta-cyclodextrin.
AAPS PharmSciTech. 2006 Sep 29; 7(3):79.AP

Abstract

Complexation of celecoxib with hydroxypropyl beta-cyclodextrin (HPbetaCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPbetaCD and on the dissolution rate of celecoxib from the HPbetaCD complexes. The phase solubility studies indicated the formation of celecoxib-HPbetaCD inclusion complexes at a 1:1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable. Addition of hydrophilic polymers markedly enhanced the complexation and solubilizing efficiencies of HPbetaCD. Solid inclusion complexes of celecoxib-HPbetaCD were prepared in 1:1 and 1:2 ratios by the kneading method, with and without the addition of hydrophilic polymers. The solubility and dissolution rate of celecoxib were significantly improved by complexation with HPbetaCD. The celecoxib-HPbetaCD (1:2) inclusion complex yielded a 36.57-fold increase in the dissolution rate of celecoxib. The addition of hydrophilic polymers also markedly enhanced the dissolution rate of celecoxib from HPbetaCD complexes: a 72.60-, 61.25-, and 39.15-fold increase was observed with PVP, HPMC, and PEG, respectively. Differential scanning calorimetry and X-ray diffractometry indicated stronger drug amorphization and entrapment in HPbetaCD because of the combined action of HPbetaCD and the hydrophilic polymers.

Authors+Show Affiliations

Industrial Pharmacy Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003. profkprc@rediffmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17025259

Citation

Chowdary, Kora Pattabhi Ramaiah, and Sekuboyina Vijaya Srinivas. "Influence of Hydrophilic Polymers On Celecoxib Complexation With Hydroxypropyl Beta-cyclodextrin." AAPS PharmSciTech, vol. 7, no. 3, 2006, p. 79.
Chowdary KP, Srinivas SV. Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl beta-cyclodextrin. AAPS PharmSciTech. 2006;7(3):79.
Chowdary, K. P., & Srinivas, S. V. (2006). Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl beta-cyclodextrin. AAPS PharmSciTech, 7(3), 79.
Chowdary KP, Srinivas SV. Influence of Hydrophilic Polymers On Celecoxib Complexation With Hydroxypropyl Beta-cyclodextrin. AAPS PharmSciTech. 2006 Sep 29;7(3):79. PubMed PMID: 17025259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl beta-cyclodextrin. AU - Chowdary,Kora Pattabhi Ramaiah, AU - Srinivas,Sekuboyina Vijaya, Y1 - 2006/09/29/ PY - 2006/10/10/pubmed PY - 2006/10/17/medline PY - 2006/10/10/entrez SP - 79 EP - 79 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 7 IS - 3 N2 - Complexation of celecoxib with hydroxypropyl beta-cyclodextrin (HPbetaCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPbetaCD and on the dissolution rate of celecoxib from the HPbetaCD complexes. The phase solubility studies indicated the formation of celecoxib-HPbetaCD inclusion complexes at a 1:1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable. Addition of hydrophilic polymers markedly enhanced the complexation and solubilizing efficiencies of HPbetaCD. Solid inclusion complexes of celecoxib-HPbetaCD were prepared in 1:1 and 1:2 ratios by the kneading method, with and without the addition of hydrophilic polymers. The solubility and dissolution rate of celecoxib were significantly improved by complexation with HPbetaCD. The celecoxib-HPbetaCD (1:2) inclusion complex yielded a 36.57-fold increase in the dissolution rate of celecoxib. The addition of hydrophilic polymers also markedly enhanced the dissolution rate of celecoxib from HPbetaCD complexes: a 72.60-, 61.25-, and 39.15-fold increase was observed with PVP, HPMC, and PEG, respectively. Differential scanning calorimetry and X-ray diffractometry indicated stronger drug amorphization and entrapment in HPbetaCD because of the combined action of HPbetaCD and the hydrophilic polymers. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/17025259/Influence_of_hydrophilic_polymers_on_celecoxib_complexation_with_hydroxypropyl_beta_cyclodextrin_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17025259/ DB - PRIME DP - Unbound Medicine ER -