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Deficiency of INFgamma producing cells in adenoids of children exposed to passive smoke.
Int J Immunopathol Pharmacol. 2006 Jul-Sep; 19(3):609-16.IJ

Abstract

Exposure to passive smoke is a very common event associated with increased susceptibility to respiratory tract infections. Many related adverse effects result from the ability of cigarette smoke extracts to interfere with the immune system, but the mechanism is not yet completely understood. The aim of the present study is to evaluate the intracellular cytokine profile in adenoids and peripheral blood cells of children exposed to passive smoke. Children undergoing adenoidectomy exposed or not exposed to passive smoke were studied. The intracellular cytokine profile of lymphocyte subsets in adenoids and in peripheral blood were evaluated by flow cytometry analysis. Children exposed to tobacco smoke showed a significantly lower percentage of INF-gamma producing CD4+ and CD8+ cells in adenoids. Moreover a significant correlation was observed between the quantity of exposure and reduction in Th1 (CD4+INFgamma+ and CD8+INFgamma+) cells in adenoids. This reduction may be a contributing factor in the increasing susceptibility to respiratory tract infection in children exposed to tobacco smoke.

Links

Publisher Full Text
journals.sagepub.com
journals.sagepub.com

Authors+Show Affiliations

Avanzini MA
Research Laboratories, Transplantation Area, IRCCS Policlinico S. Matteo, Pavia, Italy. ma.avanzini@smatteo.pv.it
Ricci A
No affiliation info available
Scaramuzza C
No affiliation info available
Semino L
No affiliation info available
Pagella F
No affiliation info available
Castellazzi AM
No affiliation info available
Marconi M
No affiliation info available
Klersy C
No affiliation info available
Pistorio A
No affiliation info available
Boner AL
No affiliation info available
Marseglia GL
No affiliation info available

MeSH

AdenoidsChildChild, PreschoolFemaleHumansInterferon-gammaInterleukin-2Interleukin-4MaleT-LymphocytesTobacco Smoke Pollution

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17026846

Citation

Avanzini, M A., et al. "Deficiency of INFgamma Producing Cells in Adenoids of Children Exposed to Passive Smoke." International Journal of Immunopathology and Pharmacology, vol. 19, no. 3, 2006, pp. 609-16.
Avanzini MA, Ricci A, Scaramuzza C, et al. Deficiency of INFgamma producing cells in adenoids of children exposed to passive smoke. Int J Immunopathol Pharmacol. 2006;19(3):609-16.
Avanzini, M. A., Ricci, A., Scaramuzza, C., Semino, L., Pagella, F., Castellazzi, A. M., Marconi, M., Klersy, C., Pistorio, A., Boner, A. L., & Marseglia, G. L. (2006). Deficiency of INFgamma producing cells in adenoids of children exposed to passive smoke. International Journal of Immunopathology and Pharmacology, 19(3), 609-16.
Avanzini MA, et al. Deficiency of INFgamma Producing Cells in Adenoids of Children Exposed to Passive Smoke. Int J Immunopathol Pharmacol. 2006 Jul-Sep;19(3):609-16. PubMed PMID: 17026846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deficiency of INFgamma producing cells in adenoids of children exposed to passive smoke. AU - Avanzini,M A, AU - Ricci,A, AU - Scaramuzza,C, AU - Semino,L, AU - Pagella,F, AU - Castellazzi,A M, AU - Marconi,M, AU - Klersy,C, AU - Pistorio,A, AU - Boner,A L, AU - Marseglia,G L, PY - 2006/10/10/pubmed PY - 2006/12/9/medline PY - 2006/10/10/entrez SP - 609 EP - 16 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 19 IS - 3 N2 - Exposure to passive smoke is a very common event associated with increased susceptibility to respiratory tract infections. Many related adverse effects result from the ability of cigarette smoke extracts to interfere with the immune system, but the mechanism is not yet completely understood. The aim of the present study is to evaluate the intracellular cytokine profile in adenoids and peripheral blood cells of children exposed to passive smoke. Children undergoing adenoidectomy exposed or not exposed to passive smoke were studied. The intracellular cytokine profile of lymphocyte subsets in adenoids and in peripheral blood were evaluated by flow cytometry analysis. Children exposed to tobacco smoke showed a significantly lower percentage of INF-gamma producing CD4+ and CD8+ cells in adenoids. Moreover a significant correlation was observed between the quantity of exposure and reduction in Th1 (CD4+INFgamma+ and CD8+INFgamma+) cells in adenoids. This reduction may be a contributing factor in the increasing susceptibility to respiratory tract infection in children exposed to tobacco smoke. SN - 0394-6320 UR - https://www.unboundmedicine.com/medline/citation/17026846/Deficiency_of_INFgamma_producing_cells_in_adenoids_of_children_exposed_to_passive_smoke_ L2 - https://journals.sagepub.com/doi/10.1177/039463200601900317?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -