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Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder.
Brain Res Bull. 2006 Oct 16; 70(4-6):386-90.BR

Abstract

INTRODUCTION

REM sleep behavior disorder (RBD) is a parasomnia characterized by a loss of atonia and an increased phasic muscle activity during REM sleep. Idiopathic RBD frequently herald an alpha-synucleinopathy, including such as Parkinson's disease (PD) and dementia with Lewy Body (DLB). Pathological changes in the anterior olfactory nucleus and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to assess olfactory function in a large group of idiopathic RBD patients.

METHODS

Fifty-four consecutive polysomnographically-confirmed iRBD patients (44 men, 10 women; mean age: 69.2+/-8.3 years; mean Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score: 4.9+/-4.3) and 54 age and gender-matched control subjects underwent the Brief University of Pennsylvania Smell Identification Test (B-SIT).

RESULTS

A marked olfactory impairment was observed in the RBD group (mean B-SIT score: 7.1+/-2.5 versus 9.4+/-1.8; p < 0.0001), with 33 (61.1%) RBD patients versus 9 (16.6%) controls showing abnormal olfactory function (p < 0.0001). No correlation was found between the degree of olfactory loss and either duration of RBD symptoms or UPDRS-III score. Deficit in recognize paint thinner odorant showed the highest positive predictive value (0.95) for identifying idiopathic RBD.

CONCLUSIONS

The olfactory deficit found in most idiopathic RBD patients shares similarities with that described in PD and may be a sign of a widespread neurodegenerative process. Its detection may help in identifying subjects at higher risk of developing an alpha-synucleinopathy-mediated neurodegeneration.

Authors+Show Affiliations

Sleep Disorders Center, Department of Neurology, Università Vita-Salute San Raffaele, Via Stamira d'Ancona n. 20, 20127 Milan, Italy. fantini.marialivia@hsr.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17027774

Citation

Fantini, Maria Livia, et al. "Olfactory Deficit in Idiopathic Rapid Eye Movements Sleep Behavior Disorder." Brain Research Bulletin, vol. 70, no. 4-6, 2006, pp. 386-90.
Fantini ML, Postuma RB, Montplaisir J, et al. Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Res Bull. 2006;70(4-6):386-90.
Fantini, M. L., Postuma, R. B., Montplaisir, J., & Ferini-Strambi, L. (2006). Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Research Bulletin, 70(4-6), 386-90.
Fantini ML, et al. Olfactory Deficit in Idiopathic Rapid Eye Movements Sleep Behavior Disorder. Brain Res Bull. 2006 Oct 16;70(4-6):386-90. PubMed PMID: 17027774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. AU - Fantini,Maria Livia, AU - Postuma,Ronald B, AU - Montplaisir,Jacques, AU - Ferini-Strambi,Luigi, Y1 - 2006/08/07/ PY - 2006/02/17/received PY - 2006/07/14/revised PY - 2006/07/17/accepted PY - 2006/10/10/pubmed PY - 2006/12/9/medline PY - 2006/10/10/entrez SP - 386 EP - 90 JF - Brain research bulletin JO - Brain Res Bull VL - 70 IS - 4-6 N2 - INTRODUCTION: REM sleep behavior disorder (RBD) is a parasomnia characterized by a loss of atonia and an increased phasic muscle activity during REM sleep. Idiopathic RBD frequently herald an alpha-synucleinopathy, including such as Parkinson's disease (PD) and dementia with Lewy Body (DLB). Pathological changes in the anterior olfactory nucleus and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to assess olfactory function in a large group of idiopathic RBD patients. METHODS: Fifty-four consecutive polysomnographically-confirmed iRBD patients (44 men, 10 women; mean age: 69.2+/-8.3 years; mean Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score: 4.9+/-4.3) and 54 age and gender-matched control subjects underwent the Brief University of Pennsylvania Smell Identification Test (B-SIT). RESULTS: A marked olfactory impairment was observed in the RBD group (mean B-SIT score: 7.1+/-2.5 versus 9.4+/-1.8; p < 0.0001), with 33 (61.1%) RBD patients versus 9 (16.6%) controls showing abnormal olfactory function (p < 0.0001). No correlation was found between the degree of olfactory loss and either duration of RBD symptoms or UPDRS-III score. Deficit in recognize paint thinner odorant showed the highest positive predictive value (0.95) for identifying idiopathic RBD. CONCLUSIONS: The olfactory deficit found in most idiopathic RBD patients shares similarities with that described in PD and may be a sign of a widespread neurodegenerative process. Its detection may help in identifying subjects at higher risk of developing an alpha-synucleinopathy-mediated neurodegeneration. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/17027774/Olfactory_deficit_in_idiopathic_rapid_eye_movements_sleep_behavior_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(06)00235-8 DB - PRIME DP - Unbound Medicine ER -