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Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease.
Am J Hypertens. 2006 Oct; 19(10):1019-24.AJ

Abstract

BACKGROUND

We investigated whether the aortic augmentation index (AIx), a measure of arterial wave reflection and stiffness, is associated with cardiorespiratory fitness in men without known coronary heart disease (CHD).

METHODS

Asymptomatic men (n = 201, mean age 51 +/- 9.2 years) referred for a screening exercise electrocardiogram (ECG) underwent applanation tonometry to obtain radial artery pulse waveforms, and an ascending aortic pressure waveform was derived by a transfer function. The AIx is the difference between the first and second systolic peak of the ascending aortic pressure waveform, expressed as a percentage of the pulse pressure. Cardiorespiratory fitness was assessed by maximal oxygen consumption (VO2max mL/min/kg) during a symptom-limited graded exercise test. Multivariable regression analyses were used to identify significant independent determinants of AIx and of VO2 max.

RESULTS

Diabetes was present in 2.5% of subjects, 34.8% had history of smoking, and 29% were hypertensive. Mean (+/- SD) AIx was 19.9% +/- 9.0% and mean VO(2 max) was 33.9 +/- 6.4 mL/min/kg. In a multivariable linear regression model, AIx was positively associated with age, hypertension, and history of smoking and inversely with heart rate, height, and body mass index (BMI). The VO2 max was significantly inversely related to AIx after adjustment for age, heart rate, height, and BMI (r = -0.22, P = .002), after further adjustment for CHD risk factors (total cholesterol, HDL-cholesterol, history of smoking, diabetes, hypertension) (P = .006), and after additional adjustment for behavioral factors (physical activity score, alcohol intake, and percent body fat) (P = .022).

CONCLUSIONS

These findings indicate that AIx, a measure of arterial wave reflection and stiffness, is inversely associated with cardiorespiratory fitness in men without CHD.

Authors+Show Affiliations

Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17027821

Citation

Binder, Josepha, et al. "Aortic Augmentation Index Is Inversely Associated With Cardiorespiratory Fitness in Men Without Known Coronary Heart Disease." American Journal of Hypertension, vol. 19, no. 10, 2006, pp. 1019-24.
Binder J, Bailey KR, Seward JB, et al. Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Am J Hypertens. 2006;19(10):1019-24.
Binder, J., Bailey, K. R., Seward, J. B., Squires, R. W., Kunihiro, T., Hensrud, D. D., & Kullo, I. J. (2006). Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. American Journal of Hypertension, 19(10), 1019-24.
Binder J, et al. Aortic Augmentation Index Is Inversely Associated With Cardiorespiratory Fitness in Men Without Known Coronary Heart Disease. Am J Hypertens. 2006;19(10):1019-24. PubMed PMID: 17027821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. AU - Binder,Josepha, AU - Bailey,Kent R, AU - Seward,James B, AU - Squires,Ray W, AU - Kunihiro,Takamu, AU - Hensrud,Donald D, AU - Kullo,Iftikhar J, PY - 2005/10/20/received PY - 2006/02/24/revised PY - 2006/02/25/accepted PY - 2006/10/10/pubmed PY - 2006/12/9/medline PY - 2006/10/10/entrez SP - 1019 EP - 24 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 19 IS - 10 N2 - BACKGROUND: We investigated whether the aortic augmentation index (AIx), a measure of arterial wave reflection and stiffness, is associated with cardiorespiratory fitness in men without known coronary heart disease (CHD). METHODS: Asymptomatic men (n = 201, mean age 51 +/- 9.2 years) referred for a screening exercise electrocardiogram (ECG) underwent applanation tonometry to obtain radial artery pulse waveforms, and an ascending aortic pressure waveform was derived by a transfer function. The AIx is the difference between the first and second systolic peak of the ascending aortic pressure waveform, expressed as a percentage of the pulse pressure. Cardiorespiratory fitness was assessed by maximal oxygen consumption (VO2max mL/min/kg) during a symptom-limited graded exercise test. Multivariable regression analyses were used to identify significant independent determinants of AIx and of VO2 max. RESULTS: Diabetes was present in 2.5% of subjects, 34.8% had history of smoking, and 29% were hypertensive. Mean (+/- SD) AIx was 19.9% +/- 9.0% and mean VO(2 max) was 33.9 +/- 6.4 mL/min/kg. In a multivariable linear regression model, AIx was positively associated with age, hypertension, and history of smoking and inversely with heart rate, height, and body mass index (BMI). The VO2 max was significantly inversely related to AIx after adjustment for age, heart rate, height, and BMI (r = -0.22, P = .002), after further adjustment for CHD risk factors (total cholesterol, HDL-cholesterol, history of smoking, diabetes, hypertension) (P = .006), and after additional adjustment for behavioral factors (physical activity score, alcohol intake, and percent body fat) (P = .022). CONCLUSIONS: These findings indicate that AIx, a measure of arterial wave reflection and stiffness, is inversely associated with cardiorespiratory fitness in men without CHD. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/17027821/Aortic_augmentation_index_is_inversely_associated_with_cardiorespiratory_fitness_in_men_without_known_coronary_heart_disease_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.02.012 DB - PRIME DP - Unbound Medicine ER -