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Serum uric acid is a determinant of metabolic syndrome in a population-based study.
Am J Hypertens. 2006 Oct; 19(10):1055-62.AJ

Abstract

BACKGROUND

Determination of serum uric acid concentrations and role in risk of metabolic syndrome (MS) were investigated in 1877 participants in a cross-sectional population-based study including a brief follow-up.

METHODS

The MS was identified by modified criteria of the Adult Treatment Panel III, and coronary heart disease (CHD) by clinical findings and Minnesota coding of resting electrocardiograms. Uric acid concentrations were measured by the uricase method.

RESULTS

Metabolic syndrome was present in 39.1% of the cohort. Linear regression analysis of uric acid levels in a model comprising 13 variables identified gender, waist girth, total cholesterol (TC), alcohol usage, triglycerides, log C-reactive protein (CRP), and log gamma-glutamyl transferase (GGT), and in women diuretic use and elevated blood pressure (BP), as significant independent covariates whereby the largest contribution (1.6 mg/dL) was generated by waist girth. Logistic regression analysis of serum uric acid for MS disclosed for the top versus the bottom tertile an odds ratio (OR) of 1.89 (95% confidence interval [CI]: 1.45-2.46) in men and women combined, after adjustment for sex, age, TC, log CRP, log GGT, alcohol, and diuretic drug use, presence of diabetes/impaired fasting glucose, elevated BP, and smoking status. This corresponded to an increase by 35% in MS likelihood for each 1 SD uric acid increment. This rate declined to a significant 15% by inclusion of waist girth into the model. The OR of uric acid concentrations for prevalent and incident CHD, adjusted for age, MS, smoking, and diuretic use, was not significant among women and only tended toward significance in men.

CONCLUSIONS

Abdominal obesity is the main determinant of uric acid variance. An increment of 1 SD in serum uric acid levels are associated in both sexes with a 35% higher MS likelihood, independent of 10 risk factors related to MS. After adjustment for waist girth, a more modest but significant likelihood persists, which suggests that serum uric acid is a determinant of MS.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul University, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17027827

Citation

Onat, Altan, et al. "Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-based Study." American Journal of Hypertension, vol. 19, no. 10, 2006, pp. 1055-62.
Onat A, Uyarel H, Hergenç G, et al. Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens. 2006;19(10):1055-62.
Onat, A., Uyarel, H., Hergenç, G., Karabulut, A., Albayrak, S., Sari, I., Yazici, M., & Keleş, I. (2006). Serum uric acid is a determinant of metabolic syndrome in a population-based study. American Journal of Hypertension, 19(10), 1055-62.
Onat A, et al. Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-based Study. Am J Hypertens. 2006;19(10):1055-62. PubMed PMID: 17027827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid is a determinant of metabolic syndrome in a population-based study. AU - Onat,Altan, AU - Uyarel,Hüseyin, AU - Hergenç,Gülay, AU - Karabulut,Ahmet, AU - Albayrak,Sinan, AU - Sari,Ibrahim, AU - Yazici,Mehmet, AU - Keleş,Ibrahim, PY - 2005/08/17/received PY - 2006/01/25/revised PY - 2006/02/16/accepted PY - 2006/10/10/pubmed PY - 2006/12/9/medline PY - 2006/10/10/entrez SP - 1055 EP - 62 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 19 IS - 10 N2 - BACKGROUND: Determination of serum uric acid concentrations and role in risk of metabolic syndrome (MS) were investigated in 1877 participants in a cross-sectional population-based study including a brief follow-up. METHODS: The MS was identified by modified criteria of the Adult Treatment Panel III, and coronary heart disease (CHD) by clinical findings and Minnesota coding of resting electrocardiograms. Uric acid concentrations were measured by the uricase method. RESULTS: Metabolic syndrome was present in 39.1% of the cohort. Linear regression analysis of uric acid levels in a model comprising 13 variables identified gender, waist girth, total cholesterol (TC), alcohol usage, triglycerides, log C-reactive protein (CRP), and log gamma-glutamyl transferase (GGT), and in women diuretic use and elevated blood pressure (BP), as significant independent covariates whereby the largest contribution (1.6 mg/dL) was generated by waist girth. Logistic regression analysis of serum uric acid for MS disclosed for the top versus the bottom tertile an odds ratio (OR) of 1.89 (95% confidence interval [CI]: 1.45-2.46) in men and women combined, after adjustment for sex, age, TC, log CRP, log GGT, alcohol, and diuretic drug use, presence of diabetes/impaired fasting glucose, elevated BP, and smoking status. This corresponded to an increase by 35% in MS likelihood for each 1 SD uric acid increment. This rate declined to a significant 15% by inclusion of waist girth into the model. The OR of uric acid concentrations for prevalent and incident CHD, adjusted for age, MS, smoking, and diuretic use, was not significant among women and only tended toward significance in men. CONCLUSIONS: Abdominal obesity is the main determinant of uric acid variance. An increment of 1 SD in serum uric acid levels are associated in both sexes with a 35% higher MS likelihood, independent of 10 risk factors related to MS. After adjustment for waist girth, a more modest but significant likelihood persists, which suggests that serum uric acid is a determinant of MS. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/17027827/Serum_uric_acid_is_a_determinant_of_metabolic_syndrome_in_a_population_based_study_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.02.014 DB - PRIME DP - Unbound Medicine ER -