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Genes and the environment in neurodegeneration.
Biosci Rep 2006; 26(5):341-67BR

Abstract

Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes.

Authors+Show Affiliations

Department of Neurosciences, University of Pisa, Via Roma 67, Pisa 56126, Italy. f.coppede@geog.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17029001

Citation

Coppedè, Fabio, et al. "Genes and the Environment in Neurodegeneration." Bioscience Reports, vol. 26, no. 5, 2006, pp. 341-67.
Coppedè F, Mancuso M, Siciliano G, et al. Genes and the environment in neurodegeneration. Biosci Rep. 2006;26(5):341-67.
Coppedè, F., Mancuso, M., Siciliano, G., Migliore, L., & Murri, L. (2006). Genes and the environment in neurodegeneration. Bioscience Reports, 26(5), pp. 341-67.
Coppedè F, et al. Genes and the Environment in Neurodegeneration. Biosci Rep. 2006;26(5):341-67. PubMed PMID: 17029001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genes and the environment in neurodegeneration. AU - Coppedè,Fabio, AU - Mancuso,Michelangelo, AU - Siciliano,Gabriele, AU - Migliore,Lucia, AU - Murri,Luigi, PY - 2006/10/10/pubmed PY - 2007/2/14/medline PY - 2006/10/10/entrez SP - 341 EP - 67 JF - Bioscience reports JO - Biosci. Rep. VL - 26 IS - 5 N2 - Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes. SN - 0144-8463 UR - https://www.unboundmedicine.com/medline/citation/17029001/Genes_and_the_environment_in_neurodegeneration_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=17029001 DB - PRIME DP - Unbound Medicine ER -