Tags

Type your tag names separated by a space and hit enter

Genes and the environment in neurodegeneration.

Abstract

Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes.

Links

  • Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurosciences, University of Pisa, Via Roma 67, Pisa 56126, Italy. f.coppede@geog.unipi.it

    , , ,

    Source

    Bioscience reports 26:5 2006 Oct pg 341-67

    MeSH

    Alzheimer Disease
    Amyotrophic Lateral Sclerosis
    Animals
    Environment
    Genetic Predisposition to Disease
    Humans
    Huntington Disease
    Mitochondria
    Models, Genetic
    Mutation
    Neurodegenerative Diseases
    Parkinson Disease
    Prion Diseases

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17029001

    Citation

    Coppedè, Fabio, et al. "Genes and the Environment in Neurodegeneration." Bioscience Reports, vol. 26, no. 5, 2006, pp. 341-67.
    Coppedè F, Mancuso M, Siciliano G, et al. Genes and the environment in neurodegeneration. Biosci Rep. 2006;26(5):341-67.
    Coppedè, F., Mancuso, M., Siciliano, G., Migliore, L., & Murri, L. (2006). Genes and the environment in neurodegeneration. Bioscience Reports, 26(5), pp. 341-67.
    Coppedè F, et al. Genes and the Environment in Neurodegeneration. Biosci Rep. 2006;26(5):341-67. PubMed PMID: 17029001.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genes and the environment in neurodegeneration. AU - Coppedè,Fabio, AU - Mancuso,Michelangelo, AU - Siciliano,Gabriele, AU - Migliore,Lucia, AU - Murri,Luigi, PY - 2006/10/10/pubmed PY - 2007/2/14/medline PY - 2006/10/10/entrez SP - 341 EP - 67 JF - Bioscience reports JO - Biosci. Rep. VL - 26 IS - 5 N2 - Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes. SN - 0144-8463 UR - https://www.unboundmedicine.com/medline/citation/17029001/Genes_and_the_environment_in_neurodegeneration_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=17029001 DB - PRIME DP - Unbound Medicine ER -