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[Associations between Ser447Ter gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Oct; 23(5):519-22.ZY

Abstract

OBJECTIVE

To investigate the relationship between lipoprotein lipase (LPL) gene Ser447Ter polymorphism and atherosclerotic cerebral infarction (CI), and to investigate the effect of Ser447Ter polymorphism on plasma lipids, carotid intima-media thickness (IMT) and carotid artery plaque (CAP) in patients with CI.

METHODS

PCR-restriction fragment lengh polymorphism (PCR-RFLP) technique was used to detect LPL gene Ser447Ter polymorphism in 166 patients with CI (CI group) and 72 healthy subjects (control group). Carotid IMT and CAP were measured with carotid color ultrasonographic doppler for the patients and the controls.

RESULTS

CG+GG carriers had lower plasma triglyceride (TG) levels and higher high density lipoprotein cholesterol (HDL-C) levels than CC carriers in CI group (P=0.001 and P=0.007 respectively). CG+GG carriers had lower plasma TG levels than CC carriers in control group (P=0.041). The frequency of G allele in CI patients was significantly lower than that in control subjects (P= 0.014). There was no statistical correlation between LPL Ser447Ter gene polymorphism and carotid IMT and CAP.

CONCLUSION

The Ser447Terls polymorphism of LPL gene is significantly associated with plasma lipids and CI. G allele genotype may lead to decrease of plasma TG and increase of plasma HDL-C. G allele may be a protective genotype of CI.

Authors+Show Affiliations

Department of Neurology, the Second Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, 510260 PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17029199

Citation

Guan, Guo-dong, et al. "[Associations Between Ser447Ter Gene Polymorphism of Lipoprotein Lipase and Atherosclerotic Cerebral Infarction]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 23, no. 5, 2006, pp. 519-22.
Guan GD, Xu E, Wang XJ, et al. [Associations between Ser447Ter gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23(5):519-22.
Guan, G. D., Xu, E., Wang, X. J., Xu, Y. H., & Qiu, S. D. (2006). [Associations between Ser447Ter gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 23(5), 519-22.
Guan GD, et al. [Associations Between Ser447Ter Gene Polymorphism of Lipoprotein Lipase and Atherosclerotic Cerebral Infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23(5):519-22. PubMed PMID: 17029199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Associations between Ser447Ter gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction]. AU - Guan,Guo-dong, AU - Xu,En, AU - Wang,Xiao-juan, AU - Xu,Yin-hong, AU - Qiu,Shao-dong, PY - 2006/10/10/pubmed PY - 2009/3/28/medline PY - 2006/10/10/entrez SP - 519 EP - 22 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 23 IS - 5 N2 - OBJECTIVE: To investigate the relationship between lipoprotein lipase (LPL) gene Ser447Ter polymorphism and atherosclerotic cerebral infarction (CI), and to investigate the effect of Ser447Ter polymorphism on plasma lipids, carotid intima-media thickness (IMT) and carotid artery plaque (CAP) in patients with CI. METHODS: PCR-restriction fragment lengh polymorphism (PCR-RFLP) technique was used to detect LPL gene Ser447Ter polymorphism in 166 patients with CI (CI group) and 72 healthy subjects (control group). Carotid IMT and CAP were measured with carotid color ultrasonographic doppler for the patients and the controls. RESULTS: CG+GG carriers had lower plasma triglyceride (TG) levels and higher high density lipoprotein cholesterol (HDL-C) levels than CC carriers in CI group (P=0.001 and P=0.007 respectively). CG+GG carriers had lower plasma TG levels than CC carriers in control group (P=0.041). The frequency of G allele in CI patients was significantly lower than that in control subjects (P= 0.014). There was no statistical correlation between LPL Ser447Ter gene polymorphism and carotid IMT and CAP. CONCLUSION: The Ser447Terls polymorphism of LPL gene is significantly associated with plasma lipids and CI. G allele genotype may lead to decrease of plasma TG and increase of plasma HDL-C. G allele may be a protective genotype of CI. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/17029199/[Associations_between_Ser447Ter_gene_polymorphism_of_lipoprotein_lipase_and_atherosclerotic_cerebral_infarction]_ DB - PRIME DP - Unbound Medicine ER -