Tags

Type your tag names separated by a space and hit enter

Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease.
Am J Gastroenterol 2006; 101(11):2457-62AJ

Abstract

OBJECTIVES

There is a controversy as to whether gastroesophageal reflux disease (GERD) exists as a spectrum of disease severity or as a categorial disease in three distinct groups: nonerosive (NERD) and erosive reflux disease (ERD) and Barrett's esophagus (BE). Aim of the study was to assess progression or regression of GERD over 2 yr in a large cohort of patients (N = 3,894) under routine clinical care in Germany, Austria, and Switzerland (ProGERD study).

METHOD

Patients with predominant heartburn, with or without esophagitis, were recruited and classified according to endoscopic status at baseline, i.e., NERD, erosive reflux disease-Los Angeles (ERD-LA) grade A/B and ERD-LA grade C/D, and BE. After an initial treatment with esomeprazole, they were followed, regardless of their response. Medical therapy or endoscopy was initiated at the discretion of their primary care physician, in line with routine care. At 2 yr, endoscopy with biopsy was performed according to the protocol.

RESULTS

After 2 yr, 25% of patients who had NERD at baseline progressed to LA A/B and 0.6% to LA C/D; 1.6% of patients who had LA A/B progressed to LA C/D and 61% regressed to NERD; 42% of patients who had LA C/D regressed to LA A/B and 50% regressed to NERD (all figures exclude patients with confirmed BE at baseline). At 2 yr, 22% of patients had been off medication for at least 3 months. Patients with ERD-LA grade C/D were at greatest risk of developing BE: 5.8% compared with 1.4% for ERD-LA grade A/B and 0.5% for NERD.

CONCLUSION

GERD does not seem to be a categorial disease. Progression and regression between grades was observed in this large cohort of patients under routine clinical care.

Authors+Show Affiliations

Faculty of Medicine, University of Duisburg/Essen, Ev. Jung-Stilling Hospital, Siegen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17029609

Citation

Labenz, Joachim, et al. "Prospective Follow-up Data From the ProGERD Study Suggest That GERD Is Not a Categorial Disease." The American Journal of Gastroenterology, vol. 101, no. 11, 2006, pp. 2457-62.
Labenz J, Nocon M, Lind T, et al. Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease. Am J Gastroenterol. 2006;101(11):2457-62.
Labenz, J., Nocon, M., Lind, T., Leodolter, A., Jaspersen, D., Meyer-Sabellek, W., ... Malfertheiner, P. (2006). Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease. The American Journal of Gastroenterology, 101(11), pp. 2457-62.
Labenz J, et al. Prospective Follow-up Data From the ProGERD Study Suggest That GERD Is Not a Categorial Disease. Am J Gastroenterol. 2006;101(11):2457-62. PubMed PMID: 17029609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease. AU - Labenz,Joachim, AU - Nocon,Marc, AU - Lind,Tore, AU - Leodolter,Andreas, AU - Jaspersen,Daniel, AU - Meyer-Sabellek,Wolfgang, AU - Stolte,Manfred, AU - Vieth,Michael, AU - Willich,Stefan N, AU - Malfertheiner,Peter, Y1 - 2006/10/04/ PY - 2006/10/13/pubmed PY - 2006/12/13/medline PY - 2006/10/13/entrez SP - 2457 EP - 62 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 101 IS - 11 N2 - OBJECTIVES: There is a controversy as to whether gastroesophageal reflux disease (GERD) exists as a spectrum of disease severity or as a categorial disease in three distinct groups: nonerosive (NERD) and erosive reflux disease (ERD) and Barrett's esophagus (BE). Aim of the study was to assess progression or regression of GERD over 2 yr in a large cohort of patients (N = 3,894) under routine clinical care in Germany, Austria, and Switzerland (ProGERD study). METHOD: Patients with predominant heartburn, with or without esophagitis, were recruited and classified according to endoscopic status at baseline, i.e., NERD, erosive reflux disease-Los Angeles (ERD-LA) grade A/B and ERD-LA grade C/D, and BE. After an initial treatment with esomeprazole, they were followed, regardless of their response. Medical therapy or endoscopy was initiated at the discretion of their primary care physician, in line with routine care. At 2 yr, endoscopy with biopsy was performed according to the protocol. RESULTS: After 2 yr, 25% of patients who had NERD at baseline progressed to LA A/B and 0.6% to LA C/D; 1.6% of patients who had LA A/B progressed to LA C/D and 61% regressed to NERD; 42% of patients who had LA C/D regressed to LA A/B and 50% regressed to NERD (all figures exclude patients with confirmed BE at baseline). At 2 yr, 22% of patients had been off medication for at least 3 months. Patients with ERD-LA grade C/D were at greatest risk of developing BE: 5.8% compared with 1.4% for ERD-LA grade A/B and 0.5% for NERD. CONCLUSION: GERD does not seem to be a categorial disease. Progression and regression between grades was observed in this large cohort of patients under routine clinical care. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/17029609/Prospective_follow_up_data_from_the_ProGERD_study_suggest_that_GERD_is_not_a_categorial_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=17029609 DB - PRIME DP - Unbound Medicine ER -