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Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: a randomised controlled trial.
Growth Horm IGF Res. 2006 Oct-Dec; 16(5-6):308-17.GH

Abstract

OBJECTIVE

To assess the effects of low dose recombinant growth hormone (GH), testosterone (T) and combined GH and T, on lipid profiles and very low density lipoprotein apolipoprotein B (VLDL apoB) metabolism.

DESIGN AND PATIENTS

Sixty-nine healthy elderly men (65-80 yr) were studied in a six month double-blind, placebo-controlled trial. Participants were randomised to placebo GH and placebo T (P), GH and placebo T (GH), T and placebo GH (T) or GH and T (GHT).

MEASUREMENTS

Plasma lipid profiles were assessed before treatment and at 6 months. VLDL apoB absolute secretion rate (ASR) and fractional catabolic rate (FCR) were measured in a subset of 21 men: P (n=5); GH (n=5); T (n=6); GHT (n=5), with an infusion of 1-(13)C leucine. Fat mass (FM) was measured by DEXA and intra-abdominal fat (IAF) by CT scan.

RESULTS

IGF-I levels increased in the GH and GHT (P<0.001) groups: testosterone increased in the T (P=0.029) and GHT (P=0.05) groups. There was no change in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B or lipoprotein(a) in the GH, GHT or T groups. In the subset of 21 men, IGF-I levels increased similarly with GH and GHT (P<0.01) but T levels increased only with T (P<0.03). FM and IAF decreased significantly only with GHT (P<0.01, P=0.01). Treatment with GH, T or GHT had no effect on VLDL apoB ASR or VLDL FCR.

CONCLUSION

Co-administration of GH and T in near physiological doses in healthy elderly men resulted in favourable changes in body composition without altering the plasma lipid profile or VLDL apoB metabolism.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, St. Thomas's Hospital, GKT School of Medicine, King's College London, SE1 7EH, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17029996

Citation

Giannoulis, Manthos G., et al. "Effects of Growth Hormone And/or Testosterone On Very Low Density Lipoprotein Apolipoprotein B100 Kinetics and Plasma Lipids in Healthy Elderly Men: a Randomised Controlled Trial." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 16, no. 5-6, 2006, pp. 308-17.
Giannoulis MG, Jackson N, Shojaee-Moradie F, et al. Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: a randomised controlled trial. Growth Horm IGF Res. 2006;16(5-6):308-17.
Giannoulis, M. G., Jackson, N., Shojaee-Moradie, F., Sonksen, P. H., Martin, F. C., & Umpleby, A. M. (2006). Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: a randomised controlled trial. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 16(5-6), 308-17.
Giannoulis MG, et al. Effects of Growth Hormone And/or Testosterone On Very Low Density Lipoprotein Apolipoprotein B100 Kinetics and Plasma Lipids in Healthy Elderly Men: a Randomised Controlled Trial. Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):308-17. PubMed PMID: 17029996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: a randomised controlled trial. AU - Giannoulis,Manthos G, AU - Jackson,Nicola, AU - Shojaee-Moradie,Fariba, AU - Sonksen,Peter H, AU - Martin,Finbarr C, AU - Umpleby,A Margot, Y1 - 2006/10/09/ PY - 2006/02/02/received PY - 2006/08/07/revised PY - 2006/08/11/accepted PY - 2006/10/13/pubmed PY - 2007/2/1/medline PY - 2006/10/13/entrez SP - 308 EP - 17 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm IGF Res VL - 16 IS - 5-6 N2 - OBJECTIVE: To assess the effects of low dose recombinant growth hormone (GH), testosterone (T) and combined GH and T, on lipid profiles and very low density lipoprotein apolipoprotein B (VLDL apoB) metabolism. DESIGN AND PATIENTS: Sixty-nine healthy elderly men (65-80 yr) were studied in a six month double-blind, placebo-controlled trial. Participants were randomised to placebo GH and placebo T (P), GH and placebo T (GH), T and placebo GH (T) or GH and T (GHT). MEASUREMENTS: Plasma lipid profiles were assessed before treatment and at 6 months. VLDL apoB absolute secretion rate (ASR) and fractional catabolic rate (FCR) were measured in a subset of 21 men: P (n=5); GH (n=5); T (n=6); GHT (n=5), with an infusion of 1-(13)C leucine. Fat mass (FM) was measured by DEXA and intra-abdominal fat (IAF) by CT scan. RESULTS: IGF-I levels increased in the GH and GHT (P<0.001) groups: testosterone increased in the T (P=0.029) and GHT (P=0.05) groups. There was no change in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B or lipoprotein(a) in the GH, GHT or T groups. In the subset of 21 men, IGF-I levels increased similarly with GH and GHT (P<0.01) but T levels increased only with T (P<0.03). FM and IAF decreased significantly only with GHT (P<0.01, P=0.01). Treatment with GH, T or GHT had no effect on VLDL apoB ASR or VLDL FCR. CONCLUSION: Co-administration of GH and T in near physiological doses in healthy elderly men resulted in favourable changes in body composition without altering the plasma lipid profile or VLDL apoB metabolism. SN - 1096-6374 UR - https://www.unboundmedicine.com/medline/citation/17029996/Effects_of_growth_hormone_and/or_testosterone_on_very_low_density_lipoprotein_apolipoprotein_B100_kinetics_and_plasma_lipids_in_healthy_elderly_men:_a_randomised_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-6374(06)00111-0 DB - PRIME DP - Unbound Medicine ER -