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Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women.
Nutrition 2006 Nov-Dec; 22(11-12):1120-8N

Abstract

OBJECTIVE

We compared the effect of supplementation with a fortified skimmed milk product (high calcium skim milk) with or without added phylloquinone (vitamin K(1)) on markers of bone formation and resorption in premenopausal women.

METHODS

Eighty-two women 20 to 35 y of age were randomly allocated to three groups. Two groups received two daily servings of high calcium skim milk (1000 mg/d of extra calcium) with or without added phylloquinone (80 microg/d) for 16 wk, and a third control group received no supplementation. Bone density was assessed at baseline and the bone markers, total osteocalcin, type I N-terminal procollagen peptide, and cross-linked C-telopeptide of type I collagen were measured at baseline and at weeks 2, 12, and 16. Serum phylloquinone and undercarboxylated osteocalcin were measured in the control and vitamin K-supplemented groups at weeks 0 and 16.

RESULTS

Baseline values for age, body mass index, and bone density did not differ across groups. In vitamin K-supplemented women, mean serum phylloquinone concentrations increased from 0.27 to 0.76 microg/L (P < 0.05) and undercarboxylated osteocalcin concentrations decreased from 9.68 to 4.46 microg/L (P < 0.05) over 16 wk. Plasma cross-linked C-telopeptide of type I collagen, total osteocalcin, and type I N-terminal procollagen peptide levels decreased significantly in both supplemented groups compared with the control group over 16 wk (cross-linked C-telopeptide of type I collagen >30%, total osteocalcin and type I N-terminal procollagen peptide >15%).

CONCLUSION

Fortified milk supplementation in premenopausal women reduced bone turnover significantly. Phylloquinone fortification substantially improved vitamin K status but had no demonstrable additive effect on bone turnover in this short-term study.

Authors+Show Affiliations

Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand. m.c.kruger@massey.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17030114

Citation

Kruger, Marlena C., et al. "Effect of Calcium Fortified Milk Supplementation With or Without Vitamin K On Biochemical Markers of Bone Turnover in Premenopausal Women." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 11-12, 2006, pp. 1120-8.
Kruger MC, Booth CL, Coad J, et al. Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. Nutrition. 2006;22(11-12):1120-8.
Kruger, M. C., Booth, C. L., Coad, J., Schollum, L. M., Kuhn-Sherlock, B., & Shearer, M. J. (2006). Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. Nutrition (Burbank, Los Angeles County, Calif.), 22(11-12), pp. 1120-8.
Kruger MC, et al. Effect of Calcium Fortified Milk Supplementation With or Without Vitamin K On Biochemical Markers of Bone Turnover in Premenopausal Women. Nutrition. 2006;22(11-12):1120-8. PubMed PMID: 17030114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. AU - Kruger,Marlena C, AU - Booth,Christine L, AU - Coad,Jane, AU - Schollum,Linda M, AU - Kuhn-Sherlock,Barbara, AU - Shearer,Martin J, Y1 - 2006/10/09/ PY - 2005/11/30/received PY - 2006/08/08/revised PY - 2006/08/16/accepted PY - 2006/10/13/pubmed PY - 2007/2/9/medline PY - 2006/10/13/entrez SP - 1120 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 11-12 N2 - OBJECTIVE: We compared the effect of supplementation with a fortified skimmed milk product (high calcium skim milk) with or without added phylloquinone (vitamin K(1)) on markers of bone formation and resorption in premenopausal women. METHODS: Eighty-two women 20 to 35 y of age were randomly allocated to three groups. Two groups received two daily servings of high calcium skim milk (1000 mg/d of extra calcium) with or without added phylloquinone (80 microg/d) for 16 wk, and a third control group received no supplementation. Bone density was assessed at baseline and the bone markers, total osteocalcin, type I N-terminal procollagen peptide, and cross-linked C-telopeptide of type I collagen were measured at baseline and at weeks 2, 12, and 16. Serum phylloquinone and undercarboxylated osteocalcin were measured in the control and vitamin K-supplemented groups at weeks 0 and 16. RESULTS: Baseline values for age, body mass index, and bone density did not differ across groups. In vitamin K-supplemented women, mean serum phylloquinone concentrations increased from 0.27 to 0.76 microg/L (P < 0.05) and undercarboxylated osteocalcin concentrations decreased from 9.68 to 4.46 microg/L (P < 0.05) over 16 wk. Plasma cross-linked C-telopeptide of type I collagen, total osteocalcin, and type I N-terminal procollagen peptide levels decreased significantly in both supplemented groups compared with the control group over 16 wk (cross-linked C-telopeptide of type I collagen >30%, total osteocalcin and type I N-terminal procollagen peptide >15%). CONCLUSION: Fortified milk supplementation in premenopausal women reduced bone turnover significantly. Phylloquinone fortification substantially improved vitamin K status but had no demonstrable additive effect on bone turnover in this short-term study. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/17030114/Effect_of_calcium_fortified_milk_supplementation_with_or_without_vitamin_K_on_biochemical_markers_of_bone_turnover_in_premenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(06)00314-5 DB - PRIME DP - Unbound Medicine ER -