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Coeliac disease and risk of mood disorders--a general population-based cohort study.
J Affect Disord 2007; 99(1-3):117-26JA

Abstract

BACKGROUND

Earlier research has indicated a positive association between coeliac disease (CD) and some mental disorders. Studies on CD and depression have inconsistent findings and we know of no study of CD and the risk of bipolar disorder (BD).

METHODS

We used Cox regression to investigate the risk of subsequent mood disorders (MD); depression and BD in 13,776 individuals with CD and 66,815 age- and sex-matched reference individuals in a general population-based cohort study in Sweden. We also studied the association between prior MD and CD through conditional logistic regression.

RESULTS

CD was associated with an increased risk of subsequent depression (Hazard ratio (HR)=1.8; 95% CI=1.6-2.2; p<0.001, based on 181 positive events in individuals with CD and 529 positive events in reference individuals). CD was not associated with subsequent BD (HR=1.1; 95% CI=0.7-1.7; p=0.779, based on 22 and 99 positive events). Individuals with prior depression (OR=2.3; 95% CI=2.0-2.8; p<0.001) or prior BD (OR=1.7; 95% CI=1.2-2.3; p=0.001) were at increased risk of a subsequent diagnosis of CD.

LIMITATIONS

Study participants with CD and MD may have more severe disease than the average patient with these disorders since they were identified through a hospital-based register.

CONCLUSIONS

CD is positively associated with subsequent depression. The risk increase for CD in individuals with prior depression and BD may be due to screening for CD among those with MD.

Authors+Show Affiliations

Department of Paediatrics, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17030405

Citation

Ludvigsson, Jonas F., et al. "Coeliac Disease and Risk of Mood Disorders--a General Population-based Cohort Study." Journal of Affective Disorders, vol. 99, no. 1-3, 2007, pp. 117-26.
Ludvigsson JF, Reutfors J, Osby U, et al. Coeliac disease and risk of mood disorders--a general population-based cohort study. J Affect Disord. 2007;99(1-3):117-26.
Ludvigsson, J. F., Reutfors, J., Osby, U., Ekbom, A., & Montgomery, S. M. (2007). Coeliac disease and risk of mood disorders--a general population-based cohort study. Journal of Affective Disorders, 99(1-3), pp. 117-26.
Ludvigsson JF, et al. Coeliac Disease and Risk of Mood Disorders--a General Population-based Cohort Study. J Affect Disord. 2007;99(1-3):117-26. PubMed PMID: 17030405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease and risk of mood disorders--a general population-based cohort study. AU - Ludvigsson,Jonas F, AU - Reutfors,Johan, AU - Osby,Urban, AU - Ekbom,Anders, AU - Montgomery,Scott M, Y1 - 2006/10/06/ PY - 2006/05/04/received PY - 2006/08/14/revised PY - 2006/08/23/accepted PY - 2006/10/13/pubmed PY - 2007/6/15/medline PY - 2006/10/13/entrez SP - 117 EP - 26 JF - Journal of affective disorders JO - J Affect Disord VL - 99 IS - 1-3 N2 - BACKGROUND: Earlier research has indicated a positive association between coeliac disease (CD) and some mental disorders. Studies on CD and depression have inconsistent findings and we know of no study of CD and the risk of bipolar disorder (BD). METHODS: We used Cox regression to investigate the risk of subsequent mood disorders (MD); depression and BD in 13,776 individuals with CD and 66,815 age- and sex-matched reference individuals in a general population-based cohort study in Sweden. We also studied the association between prior MD and CD through conditional logistic regression. RESULTS: CD was associated with an increased risk of subsequent depression (Hazard ratio (HR)=1.8; 95% CI=1.6-2.2; p<0.001, based on 181 positive events in individuals with CD and 529 positive events in reference individuals). CD was not associated with subsequent BD (HR=1.1; 95% CI=0.7-1.7; p=0.779, based on 22 and 99 positive events). Individuals with prior depression (OR=2.3; 95% CI=2.0-2.8; p<0.001) or prior BD (OR=1.7; 95% CI=1.2-2.3; p=0.001) were at increased risk of a subsequent diagnosis of CD. LIMITATIONS: Study participants with CD and MD may have more severe disease than the average patient with these disorders since they were identified through a hospital-based register. CONCLUSIONS: CD is positively associated with subsequent depression. The risk increase for CD in individuals with prior depression and BD may be due to screening for CD among those with MD. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/17030405/Coeliac_disease_and_risk_of_mood_disorders__a_general_population_based_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(06)00363-6 DB - PRIME DP - Unbound Medicine ER -