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Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis.
J Gen Virol. 2006 Nov; 87(Pt 11):3355-3359.JG

Abstract

Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.

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Authors+Show Affiliations

Ren W
Graduate School of CAS, Beijing 100039, China. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), Wuhan, Hubei 430071, China.
Li W
Institute of Zoology, CAS, Beijing 100080, China. Graduate School of CAS, Beijing 100039, China.
Yu M
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia.
Hao P
Shanghai Center for Bioinformation Technology, Shanghai 200235, China.
Zhang Y
School of Life Sciences, Fudan University, Shanghai 200433, China.
Zhou P
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), Wuhan, Hubei 430071, China.
Zhang S
Institute of Zoology, CAS, Beijing 100080, China.
Zhao G
Shanghai Center for Bioinformation Technology, Shanghai 200235, China.
Zhong Y
School of Life Sciences, Fudan University, Shanghai 200433, China.
Wang S
School of Life Sciences, Fudan University, Shanghai 200433, China. Shanghai Center for Bioinformation Technology, Shanghai 200235, China.
Wang LF
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia.
Shi Z
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), Wuhan, Hubei 430071, China.

MeSH

AnimalsChinaChiropteraGenetic VariationGenome, ViralHemagglutinins, ViralHumansMembrane GlycoproteinsOpen Reading FramesRNA-Dependent RNA PolymeraseSARS VirusSequence Homology, Amino AcidSevere Acute Respiratory SyndromeSpike Glycoprotein, CoronavirusViral Envelope ProteinsViral Matrix ProteinsViral Nonstructural ProteinsViral ProteinsViverridae

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17030870

Citation

Ren, Wuze, et al. "Full-length Genome Sequences of Two SARS-like Coronaviruses in Horseshoe Bats and Genetic Variation Analysis." The Journal of General Virology, vol. 87, no. Pt 11, 2006, pp. 3355-3359.
Ren W, Li W, Yu M, et al. Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis. J Gen Virol. 2006;87(Pt 11):3355-3359.
Ren, W., Li, W., Yu, M., Hao, P., Zhang, Y., Zhou, P., Zhang, S., Zhao, G., Zhong, Y., Wang, S., Wang, L. F., & Shi, Z. (2006). Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis. The Journal of General Virology, 87(Pt 11), 3355-3359. https://doi.org/10.1099/vir.0.82220-0
Ren W, et al. Full-length Genome Sequences of Two SARS-like Coronaviruses in Horseshoe Bats and Genetic Variation Analysis. J Gen Virol. 2006;87(Pt 11):3355-3359. PubMed PMID: 17030870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis. AU - Ren,Wuze, AU - Li,Wendong, AU - Yu,Meng, AU - Hao,Pei, AU - Zhang,Yuan, AU - Zhou,Peng, AU - Zhang,Shuyi, AU - Zhao,Guoping, AU - Zhong,Yang, AU - Wang,Shengyue, AU - Wang,Lin-Fa, AU - Shi,Zhengli, PY - 2006/10/13/pubmed PY - 2006/11/15/medline PY - 2006/10/13/entrez SP - 3355 EP - 3359 JF - The Journal of general virology JO - J Gen Virol VL - 87 IS - Pt 11 N2 - Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/17030870/Full_length_genome_sequences_of_two_SARS_like_coronaviruses_in_horseshoe_bats_and_genetic_variation_analysis_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.82220-0 DB - PRIME DP - Unbound Medicine ER -