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Oxidative degradation of BPA using TiO2 in water, and transition of estrogenic activity in the degradation pathways.
Arch Environ Contam Toxicol. 2007 Jan; 52(1):8-15.AE

Abstract

The oxidative degradation behavior of bisphenol A (BPA) using titanium dioxide (TiO(2)) in water was investigated. The main purposes were to clarify the relationship with estrogenic activity from the degradation pathways demonstrated by oxidation of BPA in water. Approximately 99% of the BPA decomposed within 300 min, and gas chromatography (GC) mass spectrometry (MS) and liquid chromatography (LC) MS analysis revealed many intermediates during the degradation process. Intermediates by decomposition of BPA, such as hydroxylated-BPA (OH-BPA), carboxylic intermediates, phenolic intermediates, and other intermediates produced by the cleavage of a benzene ring were identified and quantified. Estrogenic activities of the degradation pathways of the BPA in water were assessed by using a constructed yeast two-hybrid assay system for human estrogen receptor alpha (hERalpha) and Japanese medaka fish (Oryzias latipes) estrogen receptor alpha (medERalpha). Estrogenic activity for hERalpha and medERalpha was reduced to less than 20% of the initial activity for BPA after 240 min of UV irradiation. However, estrogenic activity for medERalpha was increased by 110% from the initial activity for BPA at 60 min of UV irradiation. It was estimated that medERalpha assay was more sensitive for BPA and the intermediates than was the hERalpha assay. From these findings, we estimate that the intermediates by the oxidation of BPA have the behaviors of xenoestrogen to the aquatic wildlife in the environment.

Authors+Show Affiliations

Graduate School of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17031755

Citation

Nomiyama, Kei, et al. "Oxidative Degradation of BPA Using TiO2 in Water, and Transition of Estrogenic Activity in the Degradation Pathways." Archives of Environmental Contamination and Toxicology, vol. 52, no. 1, 2007, pp. 8-15.
Nomiyama K, Tanizaki T, Koga T, et al. Oxidative degradation of BPA using TiO2 in water, and transition of estrogenic activity in the degradation pathways. Arch Environ Contam Toxicol. 2007;52(1):8-15.
Nomiyama, K., Tanizaki, T., Koga, T., Arizono, K., & Shinohara, R. (2007). Oxidative degradation of BPA using TiO2 in water, and transition of estrogenic activity in the degradation pathways. Archives of Environmental Contamination and Toxicology, 52(1), 8-15.
Nomiyama K, et al. Oxidative Degradation of BPA Using TiO2 in Water, and Transition of Estrogenic Activity in the Degradation Pathways. Arch Environ Contam Toxicol. 2007;52(1):8-15. PubMed PMID: 17031755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative degradation of BPA using TiO2 in water, and transition of estrogenic activity in the degradation pathways. AU - Nomiyama,Kei, AU - Tanizaki,Teiji, AU - Koga,Toyokazu, AU - Arizono,Koji, AU - Shinohara,Ryota, Y1 - 2006/10/09/ PY - 2005/08/22/received PY - 2006/05/29/accepted PY - 2006/10/13/pubmed PY - 2007/2/13/medline PY - 2006/10/13/entrez SP - 8 EP - 15 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 52 IS - 1 N2 - The oxidative degradation behavior of bisphenol A (BPA) using titanium dioxide (TiO(2)) in water was investigated. The main purposes were to clarify the relationship with estrogenic activity from the degradation pathways demonstrated by oxidation of BPA in water. Approximately 99% of the BPA decomposed within 300 min, and gas chromatography (GC) mass spectrometry (MS) and liquid chromatography (LC) MS analysis revealed many intermediates during the degradation process. Intermediates by decomposition of BPA, such as hydroxylated-BPA (OH-BPA), carboxylic intermediates, phenolic intermediates, and other intermediates produced by the cleavage of a benzene ring were identified and quantified. Estrogenic activities of the degradation pathways of the BPA in water were assessed by using a constructed yeast two-hybrid assay system for human estrogen receptor alpha (hERalpha) and Japanese medaka fish (Oryzias latipes) estrogen receptor alpha (medERalpha). Estrogenic activity for hERalpha and medERalpha was reduced to less than 20% of the initial activity for BPA after 240 min of UV irradiation. However, estrogenic activity for medERalpha was increased by 110% from the initial activity for BPA at 60 min of UV irradiation. It was estimated that medERalpha assay was more sensitive for BPA and the intermediates than was the hERalpha assay. From these findings, we estimate that the intermediates by the oxidation of BPA have the behaviors of xenoestrogen to the aquatic wildlife in the environment. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/17031755/Oxidative_degradation_of_BPA_using_TiO2_in_water_and_transition_of_estrogenic_activity_in_the_degradation_pathways_ L2 - https://dx.doi.org/10.1007/s00244-005-0204-7 DB - PRIME DP - Unbound Medicine ER -