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Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention.
J Agric Food Chem. 2006 Oct 18; 54(21):7998-8005.JA

Abstract

Increasing intakes of carotenoid-rich plant foods can increase serum carotenoid concentrations and macular pigment optical density (MPOD) in most, but not all, individuals. Research objectives for this study were to (1) characterize tissue lutein (L) and beta-carotene (BC) concentrations in carotenoid-rich spinach (Spinacia oleracea L.) cultigens and (2) determine serum carotenoid and MPOD responses in human subjects consuming spinach cultigens differing in tissue L and BC concentrations. Thirteen spinach cultigens were evaluated for carotenoid accumulations over two consecutive growing seasons. "Springer" (8.4 and 6.5 mg/100 g of fresh mass for L and BC, respectively) and "Spinner" (12.1 and 9.2 mg/100 g of fresh mass for L and BC, respectively) spinach cultigens were selected for a dietary intervention study and represented low- and high-L concentrations. The high-L ("Spinner") and low-L ("Springer") spinach treatment groups consisted of 10 subject volunteers ingesting five 50-g spinach servings/week during a 12-week intervention. Average serum L concentrations increased by 22% (P = 0.07) from baseline (0.233 micromol/L) to 12 weeks (0.297 micromol/L) for subjects consuming low-L spinach. Subjects consuming high-L spinach showed increases of 33% (P = 0.04) in serum L from baseline (0.202 micromol/L) to 12 weeks (0.300 micromol/L). Average MPOD did not change for the low-L treatment group; however, subjects in the high-L group demonstrated increases (P = 0.02) in MPOD at the 30' eccentricity between baseline (0.343) and 12 weeks (0.374). This study demonstrates that serum carotenoid and MPOD are determined by L concentrations present in the spinach matrix. Results emphasize the role of cultigen selection among vegetable crops in determining phytochemical effects on human health.

Authors+Show Affiliations

Plant Sciences Department, The University of Tennessee, Knoxville, TN 37996, USA. dkopsell@utk.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17032001

Citation

Kopsell, Dean A., et al. "Spinach Cultigen Variation for Tissue Carotenoid Concentrations Influences Human Serum Carotenoid Levels and Macular Pigment Optical Density Following a 12-week Dietary Intervention." Journal of Agricultural and Food Chemistry, vol. 54, no. 21, 2006, pp. 7998-8005.
Kopsell DA, Lefsrud MG, Kopsell DE, et al. Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. J Agric Food Chem. 2006;54(21):7998-8005.
Kopsell, D. A., Lefsrud, M. G., Kopsell, D. E., Wenzel, A. J., Gerweck, C., & Curran-Celentano, J. (2006). Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. Journal of Agricultural and Food Chemistry, 54(21), 7998-8005.
Kopsell DA, et al. Spinach Cultigen Variation for Tissue Carotenoid Concentrations Influences Human Serum Carotenoid Levels and Macular Pigment Optical Density Following a 12-week Dietary Intervention. J Agric Food Chem. 2006 Oct 18;54(21):7998-8005. PubMed PMID: 17032001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. AU - Kopsell,Dean A, AU - Lefsrud,Mark G, AU - Kopsell,David E, AU - Wenzel,Adam J, AU - Gerweck,Catherine, AU - Curran-Celentano,Joanne, PY - 2006/10/13/pubmed PY - 2006/12/9/medline PY - 2006/10/13/entrez SP - 7998 EP - 8005 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 54 IS - 21 N2 - Increasing intakes of carotenoid-rich plant foods can increase serum carotenoid concentrations and macular pigment optical density (MPOD) in most, but not all, individuals. Research objectives for this study were to (1) characterize tissue lutein (L) and beta-carotene (BC) concentrations in carotenoid-rich spinach (Spinacia oleracea L.) cultigens and (2) determine serum carotenoid and MPOD responses in human subjects consuming spinach cultigens differing in tissue L and BC concentrations. Thirteen spinach cultigens were evaluated for carotenoid accumulations over two consecutive growing seasons. "Springer" (8.4 and 6.5 mg/100 g of fresh mass for L and BC, respectively) and "Spinner" (12.1 and 9.2 mg/100 g of fresh mass for L and BC, respectively) spinach cultigens were selected for a dietary intervention study and represented low- and high-L concentrations. The high-L ("Spinner") and low-L ("Springer") spinach treatment groups consisted of 10 subject volunteers ingesting five 50-g spinach servings/week during a 12-week intervention. Average serum L concentrations increased by 22% (P = 0.07) from baseline (0.233 micromol/L) to 12 weeks (0.297 micromol/L) for subjects consuming low-L spinach. Subjects consuming high-L spinach showed increases of 33% (P = 0.04) in serum L from baseline (0.202 micromol/L) to 12 weeks (0.300 micromol/L). Average MPOD did not change for the low-L treatment group; however, subjects in the high-L group demonstrated increases (P = 0.02) in MPOD at the 30' eccentricity between baseline (0.343) and 12 weeks (0.374). This study demonstrates that serum carotenoid and MPOD are determined by L concentrations present in the spinach matrix. Results emphasize the role of cultigen selection among vegetable crops in determining phytochemical effects on human health. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17032001/Spinach_cultigen_variation_for_tissue_carotenoid_concentrations_influences_human_serum_carotenoid_levels_and_macular_pigment_optical_density_following_a_12_week_dietary_intervention_ L2 - https://dx.doi.org/10.1021/jf0614802 DB - PRIME DP - Unbound Medicine ER -