Tags

Type your tag names separated by a space and hit enter

Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests.

Abstract

Serological screening tests for coeliac disease have significantly advanced the diagnosis of this condition. The very high specificity (almost 100%) of anti-endomysial antibody detection has been repeatedly confirmed, whereas a lower specificity (90-95%) is found with anti-tissue transglutaminase antibody assays. In the study by Malekzadeh and colleagues, a group of study participants were identified with raised anti-tissue transglutaminase antibodies, but the endomysial antibody test was negative in 86%. Although many of these participants were found to have raised intra-epithelial lymphocytes in their small intestinal mucosa, there is currently insufficient evidence to confidently diagnose gluten-sensitive disease in these patients. Hence, their report that a minimum prevalence of 1:104 of gluten sensitivity is found in the general population of Iran is likely to be an over-estimate and requires confirmation.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Trinity College Centre for Health Sciences, St James Hospital, Dublin, Ireland. con.feighery@tcd.ie

    ,

    Source

    MeSH

    Adult
    Antibodies
    Autoantibodies
    Celiac Disease
    Enzyme-Linked Immunosorbent Assay
    Fluorescent Antibody Technique, Indirect
    GTP-Binding Proteins
    Humans
    Immunoglobulin A
    Mass Screening
    Sensitivity and Specificity
    Serologic Tests
    Transglutaminases
    Triticum

    Pub Type(s)

    Comment
    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    17033437

    Citation

    Feighery, Conleth, et al. "Adult Population Screening for Coeliac Disease: Comparison of Tissue-transglutaminase Antibody and Anti-endomysial Antibody Tests." European Journal of Gastroenterology & Hepatology, vol. 18, no. 11, 2006, pp. 1173-5.
    Feighery C, Conlon N, Jackson J. Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. Eur J Gastroenterol Hepatol. 2006;18(11):1173-5.
    Feighery, C., Conlon, N., & Jackson, J. (2006). Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. European Journal of Gastroenterology & Hepatology, 18(11), pp. 1173-5.
    Feighery C, Conlon N, Jackson J. Adult Population Screening for Coeliac Disease: Comparison of Tissue-transglutaminase Antibody and Anti-endomysial Antibody Tests. Eur J Gastroenterol Hepatol. 2006;18(11):1173-5. PubMed PMID: 17033437.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. AU - Feighery,Conleth, AU - Conlon,Niall, AU - Jackson,John, PY - 2006/10/13/pubmed PY - 2007/1/5/medline PY - 2006/10/13/entrez SP - 1173 EP - 5 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 18 IS - 11 N2 - Serological screening tests for coeliac disease have significantly advanced the diagnosis of this condition. The very high specificity (almost 100%) of anti-endomysial antibody detection has been repeatedly confirmed, whereas a lower specificity (90-95%) is found with anti-tissue transglutaminase antibody assays. In the study by Malekzadeh and colleagues, a group of study participants were identified with raised anti-tissue transglutaminase antibodies, but the endomysial antibody test was negative in 86%. Although many of these participants were found to have raised intra-epithelial lymphocytes in their small intestinal mucosa, there is currently insufficient evidence to confidently diagnose gluten-sensitive disease in these patients. Hence, their report that a minimum prevalence of 1:104 of gluten sensitivity is found in the general population of Iran is likely to be an over-estimate and requires confirmation. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/17033437/Adult_population_screening_for_coeliac_disease:_comparison_of_tissue_transglutaminase_antibody_and_anti_endomysial_antibody_tests_ L2 - http://Insights.ovid.com/pubmed?pmid=17033437 DB - PRIME DP - Unbound Medicine ER -