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Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests.
Eur J Gastroenterol Hepatol 2006; 18(11):1173-5EJ

Abstract

Serological screening tests for coeliac disease have significantly advanced the diagnosis of this condition. The very high specificity (almost 100%) of anti-endomysial antibody detection has been repeatedly confirmed, whereas a lower specificity (90-95%) is found with anti-tissue transglutaminase antibody assays. In the study by Malekzadeh and colleagues, a group of study participants were identified with raised anti-tissue transglutaminase antibodies, but the endomysial antibody test was negative in 86%. Although many of these participants were found to have raised intra-epithelial lymphocytes in their small intestinal mucosa, there is currently insufficient evidence to confidently diagnose gluten-sensitive disease in these patients. Hence, their report that a minimum prevalence of 1:104 of gluten sensitivity is found in the general population of Iran is likely to be an over-estimate and requires confirmation.

Authors+Show Affiliations

Trinity College Centre for Health Sciences, St James Hospital, Dublin, Ireland. con.feighery@tcd.ieNo affiliation info availableNo affiliation info available

Pub Type(s)

Comment
Comparative Study
Journal Article

Language

eng

PubMed ID

17033437

Citation

Feighery, Conleth, et al. "Adult Population Screening for Coeliac Disease: Comparison of Tissue-transglutaminase Antibody and Anti-endomysial Antibody Tests." European Journal of Gastroenterology & Hepatology, vol. 18, no. 11, 2006, pp. 1173-5.
Feighery C, Conlon N, Jackson J. Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. Eur J Gastroenterol Hepatol. 2006;18(11):1173-5.
Feighery, C., Conlon, N., & Jackson, J. (2006). Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. European Journal of Gastroenterology & Hepatology, 18(11), pp. 1173-5.
Feighery C, Conlon N, Jackson J. Adult Population Screening for Coeliac Disease: Comparison of Tissue-transglutaminase Antibody and Anti-endomysial Antibody Tests. Eur J Gastroenterol Hepatol. 2006;18(11):1173-5. PubMed PMID: 17033437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adult population screening for coeliac disease: comparison of tissue-transglutaminase antibody and anti-endomysial antibody tests. AU - Feighery,Conleth, AU - Conlon,Niall, AU - Jackson,John, PY - 2006/10/13/pubmed PY - 2007/1/5/medline PY - 2006/10/13/entrez SP - 1173 EP - 5 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 18 IS - 11 N2 - Serological screening tests for coeliac disease have significantly advanced the diagnosis of this condition. The very high specificity (almost 100%) of anti-endomysial antibody detection has been repeatedly confirmed, whereas a lower specificity (90-95%) is found with anti-tissue transglutaminase antibody assays. In the study by Malekzadeh and colleagues, a group of study participants were identified with raised anti-tissue transglutaminase antibodies, but the endomysial antibody test was negative in 86%. Although many of these participants were found to have raised intra-epithelial lymphocytes in their small intestinal mucosa, there is currently insufficient evidence to confidently diagnose gluten-sensitive disease in these patients. Hence, their report that a minimum prevalence of 1:104 of gluten sensitivity is found in the general population of Iran is likely to be an over-estimate and requires confirmation. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/17033437/Adult_population_screening_for_coeliac_disease:_comparison_of_tissue_transglutaminase_antibody_and_anti_endomysial_antibody_tests_ L2 - http://Insights.ovid.com/pubmed?pmid=17033437 DB - PRIME DP - Unbound Medicine ER -