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Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions.
J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):506-11.JP

Abstract

OBJECTIVE

The aim of the study was to compare the benefits of 2 different therapeutic approaches on cardiovascular risk factors (CVRF) in obese children and adolescents.

METHODS

We analyzed the changes of weight status (as standard deviation score-body mass index [SDS-BMI]), blood pressure, lipids, and insulin levels in obese children (age range, 10-14 years) during a 1-year outpatient intervention based on lifestyle changes (group A, n = 124) and during a 6-week inpatient intervention program with dietary restriction and exercise therapy (group B, n = 119). In addition, we studied these parameters in 65 obese children without intervention for 1 year (control group).

RESULTS

Age, degree of overweight, sex, and CVRF did not differ significantly between the control group and the intervention groups at baseline. During the observation period, CVRF did not change in the control group, whereas SDS-BMI slightly increased (+0.1 SDS-BMI). The SDS-BMI decreased significantly (P < 0.001) in group A (SDS-BMI, -0.40) and comparably in group B (SDS-BMI, -0.43). The decreases of total (P < 0.001) and low-density lipoprotein-cholesterol levels (P = 0.049) were significantly greater in group B, whereas triglyceride (P = 0.040) and insulin (P = 0.006) levels decreased significantly and were more pronounced in group A. High-density lipoprotein-cholesterol level increased significantly (P < 0.001) only in group A. Blood pressure decreased significantly (P < 0.01) and comparably in both intervention groups (A and B).

CONCLUSIONS

In contrast to obese children without intervention, CVRF improved in obese children with intervention. The 6-week inpatient intervention led to a significant greater decrease of total and low-density lipoprotein-cholesterol levels as compared with the 1-year outpatient intervention, although the outpatient intervention yielded a significantly greater improvement in insulin, triglycerides, and high-density lipoprotein-cholesterol levels.

Authors+Show Affiliations

Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Witten, Germany. T.Reinehr@kinderklinik-datteln.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17033527

Citation

Reinehr, Thomas, et al. "Changes of Cardiovascular Risk Factors in Obese Children Effects of Inpatient and Outpatient Interventions." Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 4, 2006, pp. 506-11.
Reinehr T, de Sousa G, Wabitsch M. Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions. J Pediatr Gastroenterol Nutr. 2006;43(4):506-11.
Reinehr, T., de Sousa, G., & Wabitsch, M. (2006). Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions. Journal of Pediatric Gastroenterology and Nutrition, 43(4), 506-11.
Reinehr T, de Sousa G, Wabitsch M. Changes of Cardiovascular Risk Factors in Obese Children Effects of Inpatient and Outpatient Interventions. J Pediatr Gastroenterol Nutr. 2006;43(4):506-11. PubMed PMID: 17033527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions. AU - Reinehr,Thomas, AU - de Sousa,Gideon, AU - Wabitsch,Martin, PY - 2006/10/13/pubmed PY - 2006/10/25/medline PY - 2006/10/13/entrez SP - 506 EP - 11 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 43 IS - 4 N2 - OBJECTIVE: The aim of the study was to compare the benefits of 2 different therapeutic approaches on cardiovascular risk factors (CVRF) in obese children and adolescents. METHODS: We analyzed the changes of weight status (as standard deviation score-body mass index [SDS-BMI]), blood pressure, lipids, and insulin levels in obese children (age range, 10-14 years) during a 1-year outpatient intervention based on lifestyle changes (group A, n = 124) and during a 6-week inpatient intervention program with dietary restriction and exercise therapy (group B, n = 119). In addition, we studied these parameters in 65 obese children without intervention for 1 year (control group). RESULTS: Age, degree of overweight, sex, and CVRF did not differ significantly between the control group and the intervention groups at baseline. During the observation period, CVRF did not change in the control group, whereas SDS-BMI slightly increased (+0.1 SDS-BMI). The SDS-BMI decreased significantly (P < 0.001) in group A (SDS-BMI, -0.40) and comparably in group B (SDS-BMI, -0.43). The decreases of total (P < 0.001) and low-density lipoprotein-cholesterol levels (P = 0.049) were significantly greater in group B, whereas triglyceride (P = 0.040) and insulin (P = 0.006) levels decreased significantly and were more pronounced in group A. High-density lipoprotein-cholesterol level increased significantly (P < 0.001) only in group A. Blood pressure decreased significantly (P < 0.01) and comparably in both intervention groups (A and B). CONCLUSIONS: In contrast to obese children without intervention, CVRF improved in obese children with intervention. The 6-week inpatient intervention led to a significant greater decrease of total and low-density lipoprotein-cholesterol levels as compared with the 1-year outpatient intervention, although the outpatient intervention yielded a significantly greater improvement in insulin, triglycerides, and high-density lipoprotein-cholesterol levels. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/17033527/Changes_of_cardiovascular_risk_factors_in_obese_children_effects_of_inpatient_and_outpatient_interventions_ L2 - http://dx.doi.org/10.1097/01.mpg.0000235752.29735.31 DB - PRIME DP - Unbound Medicine ER -