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Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial.
Dermatol Surg. 2006 Oct; 32(10):1237-43.DS

Abstract

BACKGROUND

Eflornithine cream is approved for the reduction of unwanted facial hair in women. The mechanism of action for eflornithine is reduction in follicular cell growth rate, while laser photoepilation heats hair and adjacent tissues to suspend growth.

OBJECTIVE

The objective was to assess the efficacy and safety of eflornithine or vehicle with laser therapy in the treatment of unwanted facial hair in women.

METHODS

Subjects were randomized to treatment with eflornithine on one side of the face and vehicle on the contralateral side for 34 weeks. Subjects received Nd:YAG or alexandrite laser therapy to both sides of the face at Weeks 2 and 10. Blinded evaluations included left to right comparisons and appearance relative to baseline.

RESULTS

Fifty-four women completed the trial. From Weeks 6 through 22, eflornithine-treated sides showed significant reduction in hair growth. By Week 34, no significant differences were seen. Subject grading showed significant and persistent hair reduction through Week 34 for eflornithine-treated sides. The safety profile for combination therapy is similar to eflornithine alone.

CONCLUSION

Eflornithine is safely used in conjunction with laser hair removal treatments and promotes more rapid hair removal when combined with laser treatment. Patients demonstrate a clear preference for treatment with laser and eflornithine.

Authors+Show Affiliations

Therapeutics, Inc., San Diego, California, USA. ssmith@therapeuticsresearch.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17034372

Citation

Smith, Stacy R., et al. "Eflornithine Cream Combined With Laser Therapy in the Management of Unwanted Facial Hair Growth in Women: a Randomized Trial." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], vol. 32, no. 10, 2006, pp. 1237-43.
Smith SR, Piacquadio DJ, Beger B, et al. Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial. Dermatol Surg. 2006;32(10):1237-43.
Smith, S. R., Piacquadio, D. J., Beger, B., & Littler, C. (2006). Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 32(10), 1237-43.
Smith SR, et al. Eflornithine Cream Combined With Laser Therapy in the Management of Unwanted Facial Hair Growth in Women: a Randomized Trial. Dermatol Surg. 2006;32(10):1237-43. PubMed PMID: 17034372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial. AU - Smith,Stacy R, AU - Piacquadio,Daniel J, AU - Beger,Brian, AU - Littler,Curt, PY - 2006/10/13/pubmed PY - 2006/11/9/medline PY - 2006/10/13/entrez SP - 1237 EP - 43 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 32 IS - 10 N2 - BACKGROUND: Eflornithine cream is approved for the reduction of unwanted facial hair in women. The mechanism of action for eflornithine is reduction in follicular cell growth rate, while laser photoepilation heats hair and adjacent tissues to suspend growth. OBJECTIVE: The objective was to assess the efficacy and safety of eflornithine or vehicle with laser therapy in the treatment of unwanted facial hair in women. METHODS: Subjects were randomized to treatment with eflornithine on one side of the face and vehicle on the contralateral side for 34 weeks. Subjects received Nd:YAG or alexandrite laser therapy to both sides of the face at Weeks 2 and 10. Blinded evaluations included left to right comparisons and appearance relative to baseline. RESULTS: Fifty-four women completed the trial. From Weeks 6 through 22, eflornithine-treated sides showed significant reduction in hair growth. By Week 34, no significant differences were seen. Subject grading showed significant and persistent hair reduction through Week 34 for eflornithine-treated sides. The safety profile for combination therapy is similar to eflornithine alone. CONCLUSION: Eflornithine is safely used in conjunction with laser hair removal treatments and promotes more rapid hair removal when combined with laser treatment. Patients demonstrate a clear preference for treatment with laser and eflornithine. SN - 1076-0512 UR - https://www.unboundmedicine.com/medline/citation/17034372/Eflornithine_cream_combined_with_laser_therapy_in_the_management_of_unwanted_facial_hair_growth_in_women:_a_randomized_trial_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2006&volume=32&issue=10&spage=1237 DB - PRIME DP - Unbound Medicine ER -