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Evaluation of tests for serological diagnosis of scrub typhus.
Trop Doct. 2006 Oct; 36(4):212-3.TD

Abstract

Two specific serological tests, a Dot enzyme immunoassay (EIA) and an immunoglobulin (Ig)M enzyme-linked immunosorbent assay (ELISA) using the 56 kDa antigen and the Weil-Felix test were evaluated for diagnosis of scrub typhus. Sensitivity of 100, 86.5 and 43.5% were observed with Dot EIA, IgM ELISA and Weil-Felix test, respectively. False-positive reactions were observed in patients with falciparum malaria, pulmonary tuberculosis, S. viridans septicemia and typhoid fever using Dot EIA and IgM ELISA. Therefore, although Dot EIA and IgM ELISA are useful in the serodiagnosis of scrub typhus, efforts should be made to rule out other febrile illnesses.

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Authors+Show Affiliations

Prakash JA
Department of Clinical Microbiology, Unit I, Christian Medical College, Vellore-632004, India.
Abraham OC
No affiliation info available
Mathai E
No affiliation info available

MeSH

Antibodies, BacterialAntigens, BacterialEnzyme-Linked Immunosorbent AssayHumansImmunoenzyme TechniquesImmunoglobulin MOrientia tsutsugamushiPredictive Value of TestsScrub TyphusSensitivity and Specificity

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17034691

Citation

Prakash, J A J., et al. "Evaluation of Tests for Serological Diagnosis of Scrub Typhus." Tropical Doctor, vol. 36, no. 4, 2006, pp. 212-3.
Prakash JA, Abraham OC, Mathai E. Evaluation of tests for serological diagnosis of scrub typhus. Trop Doct. 2006;36(4):212-3.
Prakash, J. A., Abraham, O. C., & Mathai, E. (2006). Evaluation of tests for serological diagnosis of scrub typhus. Tropical Doctor, 36(4), 212-3.
Prakash JA, Abraham OC, Mathai E. Evaluation of Tests for Serological Diagnosis of Scrub Typhus. Trop Doct. 2006;36(4):212-3. PubMed PMID: 17034691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of tests for serological diagnosis of scrub typhus. AU - Prakash,J A J, AU - Abraham,O C, AU - Mathai,Elizabeth, PY - 2006/10/13/pubmed PY - 2006/12/12/medline PY - 2006/10/13/entrez SP - 212 EP - 3 JF - Tropical doctor JO - Trop Doct VL - 36 IS - 4 N2 - Two specific serological tests, a Dot enzyme immunoassay (EIA) and an immunoglobulin (Ig)M enzyme-linked immunosorbent assay (ELISA) using the 56 kDa antigen and the Weil-Felix test were evaluated for diagnosis of scrub typhus. Sensitivity of 100, 86.5 and 43.5% were observed with Dot EIA, IgM ELISA and Weil-Felix test, respectively. False-positive reactions were observed in patients with falciparum malaria, pulmonary tuberculosis, S. viridans septicemia and typhoid fever using Dot EIA and IgM ELISA. Therefore, although Dot EIA and IgM ELISA are useful in the serodiagnosis of scrub typhus, efforts should be made to rule out other febrile illnesses. SN - 0049-4755 UR - https://www.unboundmedicine.com/medline/citation/17034691/Evaluation_of_tests_for_serological_diagnosis_of_scrub_typhus_ L2 - https://journals.sagepub.com/doi/10.1258/004947506778604715?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -