Tags

Type your tag names separated by a space and hit enter

Evaluation of the 4q32-34 locus in European familial pancreatic cancer.
Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1948-55.CE

Abstract

BACKGROUND

Familial pancreatic cancer (FPC) describes a group of families where the inheritance of pancreatic cancer is consistent with an autosomal-dominant mode of inheritance. The 4q32-34 region has been previously identified as a potential locus for FPC in a large American family.

METHODS

The region was allelotyped in 231 individuals from 77 European families using nine microsatellite markers, and haplotyping was possible in 191 individuals from 41 families. Families were selected based on at least two affected first-degree relatives with no other cancer syndromes.

RESULTS

Linkage to most of the locus was excluded based on LOD scores less than -2.0. Eight families were excluded from linkage to 4q32-34 based on haplotypes not segregating with the disease compared with a predicted six to seven families. Two groups of families were identified, which seem to share common alleles within the minimal disease-associated region of 4q32-34, one group with an apparently earlier age of cancer death than the other pancreatic cancer families. Four genes were identified with potential tumor suppressor roles within the locus in regions that could not be excluded based on the LOD score. These were HMGB2, PPID, MORF4, and SPOCK3. DNA sequence analysis of exons of these genes in affected individuals and in pancreatic cancer cell lines did not reveal any mutations.

CONCLUSION

This locus is unlikely to harbor a FPC gene in the majority of our European families.

Authors+Show Affiliations

Division of Surgery and Oncology, University of Liverpool, Liverpool, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17035404

Citation

Earl, Julie, et al. "Evaluation of the 4q32-34 Locus in European Familial Pancreatic Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 10, 2006, pp. 1948-55.
Earl J, Yan L, Vitone LJ, et al. Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(10):1948-55.
Earl, J., Yan, L., Vitone, L. J., Risk, J., Kemp, S. J., McFaul, C., Neoptolemos, J. P., Greenhalf, W., Kress, R., Sina-Frey, M., Hahn, S. A., Rieder, H., & Bartsch, D. K. (2006). Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(10), 1948-55.
Earl J, et al. Evaluation of the 4q32-34 Locus in European Familial Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(10):1948-55. PubMed PMID: 17035404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the 4q32-34 locus in European familial pancreatic cancer. AU - Earl,Julie, AU - Yan,Li, AU - Vitone,Louis J, AU - Risk,Janet, AU - Kemp,Steve J, AU - McFaul,Chris, AU - Neoptolemos,John P, AU - Greenhalf,William, AU - ,, AU - Kress,Ralf, AU - Sina-Frey,Mercedes, AU - Hahn,Stephan A, AU - Rieder,Harald, AU - Bartsch,Detlef K, AU - ,, PY - 2006/10/13/pubmed PY - 2007/6/21/medline PY - 2006/10/13/entrez SP - 1948 EP - 55 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 10 N2 - BACKGROUND: Familial pancreatic cancer (FPC) describes a group of families where the inheritance of pancreatic cancer is consistent with an autosomal-dominant mode of inheritance. The 4q32-34 region has been previously identified as a potential locus for FPC in a large American family. METHODS: The region was allelotyped in 231 individuals from 77 European families using nine microsatellite markers, and haplotyping was possible in 191 individuals from 41 families. Families were selected based on at least two affected first-degree relatives with no other cancer syndromes. RESULTS: Linkage to most of the locus was excluded based on LOD scores less than -2.0. Eight families were excluded from linkage to 4q32-34 based on haplotypes not segregating with the disease compared with a predicted six to seven families. Two groups of families were identified, which seem to share common alleles within the minimal disease-associated region of 4q32-34, one group with an apparently earlier age of cancer death than the other pancreatic cancer families. Four genes were identified with potential tumor suppressor roles within the locus in regions that could not be excluded based on the LOD score. These were HMGB2, PPID, MORF4, and SPOCK3. DNA sequence analysis of exons of these genes in affected individuals and in pancreatic cancer cell lines did not reveal any mutations. CONCLUSION: This locus is unlikely to harbor a FPC gene in the majority of our European families. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17035404/Evaluation_of_the_4q32_34_locus_in_European_familial_pancreatic_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17035404 DB - PRIME DP - Unbound Medicine ER -