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Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study.
Int J Cancer 2007; 120(1):128-32IJ

Abstract

The relations between tobacco, alcohol and risk of gastric cancer need to be established, and any gain from preventive measures should be estimated. We conducted a population-based, prospective cohort study in Nord-Trondelag county in Norway. During 1984-1986, adult residents were invited to a health survey and they answered questionnaires that assessed exposure to tobacco and alcohol, together with potential confounding factors. The exposure assessment regarding alcohol was limited to a 14-day period. New gastric cancers that occurred during follow-up (1984-2002) were identified by linkage to the Norwegian Cancer Registry. Cox proportion hazards regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CI), adjusted for sex, education and body mass index. Follow-up of 1,117,648 person-years at risk among 69,962 cohort members revealed 251 gastric cancers, including 224 noncardia cancers. The risk was almost twice as high in daily smokers (HR = 1.88 [CI 95% = 1.33-2.67]) as in never smokers. Independent dose-response relations were found with earlier age at initiation (p = 0.02), frequency (p = 0.00) and duration of smoking (p = 0.00). Attributable risk (AR) of gastric cancer among current smokers was 8.7/100,000 person-years and the corresponding population AR was 18.4%. No statistically significant associations between various degrees of exposure to alcohol and risk of gastric cancer was revealed, but combined high use of cigarettes (>20/day) and alcohol (>5 occasions/14 days) increased the risk of noncardia gastric cancer nearly 5-fold (HR = 4.90 [95% CI = 1.90-12.62]), compared to nonusers. It is concluded that smoking is a dose-dependent risk factor for gastric cancer. Combined high exposure to smoking and alcohol further increases the risk. Successful preventive measures could considerably reduce the incidence of gastric cancer.

Authors+Show Affiliations

Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. krister.sjodahl@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17036324

Citation

Sjödahl, Krister, et al. "Smoking and Alcohol Drinking in Relation to Risk of Gastric Cancer: a Population-based, Prospective Cohort Study." International Journal of Cancer, vol. 120, no. 1, 2007, pp. 128-32.
Sjödahl K, Lu Y, Nilsen TI, et al. Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study. Int J Cancer. 2007;120(1):128-32.
Sjödahl, K., Lu, Y., Nilsen, T. I., Ye, W., Hveem, K., Vatten, L., & Lagergren, J. (2007). Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study. International Journal of Cancer, 120(1), pp. 128-32.
Sjödahl K, et al. Smoking and Alcohol Drinking in Relation to Risk of Gastric Cancer: a Population-based, Prospective Cohort Study. Int J Cancer. 2007 Jan 1;120(1):128-32. PubMed PMID: 17036324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study. AU - Sjödahl,Krister, AU - Lu,Yunxia, AU - Nilsen,Tom I L, AU - Ye,Weimin, AU - Hveem,Kristian, AU - Vatten,Lars, AU - Lagergren,Jesper, PY - 2006/10/13/pubmed PY - 2007/2/9/medline PY - 2006/10/13/entrez SP - 128 EP - 32 JF - International journal of cancer JO - Int. J. Cancer VL - 120 IS - 1 N2 - The relations between tobacco, alcohol and risk of gastric cancer need to be established, and any gain from preventive measures should be estimated. We conducted a population-based, prospective cohort study in Nord-Trondelag county in Norway. During 1984-1986, adult residents were invited to a health survey and they answered questionnaires that assessed exposure to tobacco and alcohol, together with potential confounding factors. The exposure assessment regarding alcohol was limited to a 14-day period. New gastric cancers that occurred during follow-up (1984-2002) were identified by linkage to the Norwegian Cancer Registry. Cox proportion hazards regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CI), adjusted for sex, education and body mass index. Follow-up of 1,117,648 person-years at risk among 69,962 cohort members revealed 251 gastric cancers, including 224 noncardia cancers. The risk was almost twice as high in daily smokers (HR = 1.88 [CI 95% = 1.33-2.67]) as in never smokers. Independent dose-response relations were found with earlier age at initiation (p = 0.02), frequency (p = 0.00) and duration of smoking (p = 0.00). Attributable risk (AR) of gastric cancer among current smokers was 8.7/100,000 person-years and the corresponding population AR was 18.4%. No statistically significant associations between various degrees of exposure to alcohol and risk of gastric cancer was revealed, but combined high use of cigarettes (>20/day) and alcohol (>5 occasions/14 days) increased the risk of noncardia gastric cancer nearly 5-fold (HR = 4.90 [95% CI = 1.90-12.62]), compared to nonusers. It is concluded that smoking is a dose-dependent risk factor for gastric cancer. Combined high exposure to smoking and alcohol further increases the risk. Successful preventive measures could considerably reduce the incidence of gastric cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17036324/Smoking_and_alcohol_drinking_in_relation_to_risk_of_gastric_cancer:_a_population_based_prospective_cohort_study_ L2 - https://doi.org/10.1002/ijc.22157 DB - PRIME DP - Unbound Medicine ER -