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[Effects of electroacupuncture on behaviors and dopaminergic neurons in the rat of Parkinson's disease].

Abstract

OBJECTIVE

To explore the possibility of electroacupuncture (EA) for prevention of the injury of dopaminergic neurons in the substantia nigra of the rat with Parkinson's disease.

METHODS

Wistar rats were randomly divided into a normal group, a model group, a sham-operation group and an EA group. 6-OH-DA was injected into right substantia nigra of the midbrain to made Parkinson's disease rat model with single side substantia nigra injury, and TH/TUNEL method and rotation behavior observation method were used to observe changes of rotation behavior and apoptosis of dopaminergic neurons in the substantia nigra after EA at "Taichong" (LR 3) and "Fengfu" (GV 16) for 3 d, 7 d and 14 d.

RESULTS

The rotation times/min were same at 3 d, 7 d and 14 d were the basically same in the model group, and at 14 d significantly decreased in the EA group (P<0.05); the rotation starting time at 7 d and 14 d in the model group were significantly longer than those in the EA group (P<0.05); the rotation lasting time at 3 d, 7 d and 14 d in the model group and the EA group were gradually shortened (P<0.01, or P<0.05), but at 7 d, 14 d in the model group were significantly longer than those in the EA group (P<0.05); the DA neuron apoptosis number in the model group were significantly higher than those in the normal group, with a very significant difference (P<0.01); the apoptosis number in the EA group tended to decrease, at 7 d and 14 d were significantly lower than that in the model group (P<0.05).

CONCLUSION

Electroacupuncture can effectively prevent from injury of dopaminergic neurons in the substantia nigra of the rat with Parkinson's disease.

Authors+Show Affiliations

,

Department of Postgraduate Students, Hubei College of TCM, Wuhan 430061, China. mj-1964@163.com

,

Source

MeSH

Animals
Apoptosis
Behavior, Animal
Electroacupuncture
Female
Male
Parkinson Disease
Rats
Rats, Wistar
Rotation
Substantia Nigra

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17036487

Citation

TY - JOUR T1 - [Effects of electroacupuncture on behaviors and dopaminergic neurons in the rat of Parkinson's disease]. AU - Ma,Jun, AU - Wang,Yan-chun, AU - Gan,Shui-yong, PY - 2006/10/14/pubmed PY - 2006/10/27/medline PY - 2006/10/14/entrez SP - 655 EP - 7 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 26 IS - 9 N2 - OBJECTIVE: To explore the possibility of electroacupuncture (EA) for prevention of the injury of dopaminergic neurons in the substantia nigra of the rat with Parkinson's disease. METHODS: Wistar rats were randomly divided into a normal group, a model group, a sham-operation group and an EA group. 6-OH-DA was injected into right substantia nigra of the midbrain to made Parkinson's disease rat model with single side substantia nigra injury, and TH/TUNEL method and rotation behavior observation method were used to observe changes of rotation behavior and apoptosis of dopaminergic neurons in the substantia nigra after EA at "Taichong" (LR 3) and "Fengfu" (GV 16) for 3 d, 7 d and 14 d. RESULTS: The rotation times/min were same at 3 d, 7 d and 14 d were the basically same in the model group, and at 14 d significantly decreased in the EA group (P<0.05); the rotation starting time at 7 d and 14 d in the model group were significantly longer than those in the EA group (P<0.05); the rotation lasting time at 3 d, 7 d and 14 d in the model group and the EA group were gradually shortened (P<0.01, or P<0.05), but at 7 d, 14 d in the model group were significantly longer than those in the EA group (P<0.05); the DA neuron apoptosis number in the model group were significantly higher than those in the normal group, with a very significant difference (P<0.01); the apoptosis number in the EA group tended to decrease, at 7 d and 14 d were significantly lower than that in the model group (P<0.05). CONCLUSION: Electroacupuncture can effectively prevent from injury of dopaminergic neurons in the substantia nigra of the rat with Parkinson's disease. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/17036487/ L2 - https://medlineplus.gov/parkinsonsdisease.html ER -