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Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.
Annu Rev Physiol. 2007; 69:171-99.AR

Abstract

Steroid hormone receptors (SRs) are ligand-activated transcription factors and sensors for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast or prostate. Recent discoveries suggest that several protein kinases are rapidly activated in response to steroid hormone binding to cytoplasmic SRs. Induction of rapid signaling upon SR ligand binding ensures that receptors and coregulators are appropriately phosphorylated as part of optimal transcription complexes. Alternatively, SR-activated kinase cascades provide additional avenues for SR-regulated gene expression independent of SR nuclear action. We provide an overview of SR and signaling cross talk in breast and prostate cancers, using the human progesterone receptor (PR) and androgen receptor (AR) as models. Kinases are emerging as key mediators of SR action. Cross talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues; such cross talk is suspected to contribute to cancer biology.

Authors+Show Affiliations

Department of Medicine (Division of Hematology, Oncology, and Transplant), USA. Lange047@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

17037979

Citation

Lange, Carol A., et al. "Integration of Rapid Signaling Events With Steroid Hormone Receptor Action in Breast and Prostate Cancer." Annual Review of Physiology, vol. 69, 2007, pp. 171-99.
Lange CA, Gioeli D, Hammes SR, et al. Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annu Rev Physiol. 2007;69:171-99.
Lange, C. A., Gioeli, D., Hammes, S. R., & Marker, P. C. (2007). Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annual Review of Physiology, 69, 171-99.
Lange CA, et al. Integration of Rapid Signaling Events With Steroid Hormone Receptor Action in Breast and Prostate Cancer. Annu Rev Physiol. 2007;69:171-99. PubMed PMID: 17037979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. AU - Lange,Carol A, AU - Gioeli,Daniel, AU - Hammes,Stephen R, AU - Marker,Paul C, PY - 2006/10/14/pubmed PY - 2007/4/27/medline PY - 2006/10/14/entrez SP - 171 EP - 99 JF - Annual review of physiology JO - Annu Rev Physiol VL - 69 N2 - Steroid hormone receptors (SRs) are ligand-activated transcription factors and sensors for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast or prostate. Recent discoveries suggest that several protein kinases are rapidly activated in response to steroid hormone binding to cytoplasmic SRs. Induction of rapid signaling upon SR ligand binding ensures that receptors and coregulators are appropriately phosphorylated as part of optimal transcription complexes. Alternatively, SR-activated kinase cascades provide additional avenues for SR-regulated gene expression independent of SR nuclear action. We provide an overview of SR and signaling cross talk in breast and prostate cancers, using the human progesterone receptor (PR) and androgen receptor (AR) as models. Kinases are emerging as key mediators of SR action. Cross talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues; such cross talk is suspected to contribute to cancer biology. SN - 0066-4278 UR - https://www.unboundmedicine.com/medline/citation/17037979/Integration_of_rapid_signaling_events_with_steroid_hormone_receptor_action_in_breast_and_prostate_cancer_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev.physiol.69.031905.160319?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -