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Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients.
J Invest Dermatol. 2007 Jan; 127(1):129-34.JI

Abstract

Involved regions of the skin in atopic dermatitis (AD) patients have an altered barrier function. Whether uninvolved skin also has a diminished barrier is controversial. To assess the barrier function of uninvolved skin in AD patients, the percutaneous penetration of polyethylene glycols (PEGs) of various molecular sizes was determined in vivo in AD patients and control subjects using tape stripping of the stratum corneum (SC). The diffusion and partition coefficients were determined using Fick's second law of diffusion. The SC thickness was similar in both groups; however, the trans-epidermal water loss was higher in atopic skin. The apparent diffusion coefficient of PEGs through atopic skin was twice as high as through normal skin, and decreased with increasing molecular weight (MW) in both groups. The partition coefficient in the skin of AD patients was half of that for normal skin but as for normal skin, there was no MW dependency. Although atopic skin exhibited altered barrier with respect to diffusion and partitioning, the permeability coefficients were nearly the same for atopic and normal skin. The results support the assumption of altered skin barrier of AD patients even in the skin that is visibly unaffected by disease.

Authors+Show Affiliations

Jakasa I
Department: Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. i.jakasa@amc.uva.nl
Verberk MM
No affiliation info available
Esposito M
No affiliation info available
Bos JD
No affiliation info available
Kezic S
No affiliation info available

MeSH

AdolescentAdultDermatitis, AtopicDiffusionFemaleHumansMaleMiddle AgedPermeabilityPolyethylene GlycolsSkin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17039242

Citation

Jakasa, Ivone, et al. "Altered Penetration of Polyethylene Glycols Into Uninvolved Skin of Atopic Dermatitis Patients." The Journal of Investigative Dermatology, vol. 127, no. 1, 2007, pp. 129-34.
Jakasa I, Verberk MM, Esposito M, et al. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol. 2007;127(1):129-34.
Jakasa, I., Verberk, M. M., Esposito, M., Bos, J. D., & Kezic, S. (2007). Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. The Journal of Investigative Dermatology, 127(1), 129-34.
Jakasa I, et al. Altered Penetration of Polyethylene Glycols Into Uninvolved Skin of Atopic Dermatitis Patients. J Invest Dermatol. 2007;127(1):129-34. PubMed PMID: 17039242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. AU - Jakasa,Ivone, AU - Verberk,Maarten M, AU - Esposito,Maria, AU - Bos,Jan D, AU - Kezic,Sanja, Y1 - 2006/10/12/ PY - 2006/10/14/pubmed PY - 2007/1/4/medline PY - 2006/10/14/entrez SP - 129 EP - 34 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 127 IS - 1 N2 - Involved regions of the skin in atopic dermatitis (AD) patients have an altered barrier function. Whether uninvolved skin also has a diminished barrier is controversial. To assess the barrier function of uninvolved skin in AD patients, the percutaneous penetration of polyethylene glycols (PEGs) of various molecular sizes was determined in vivo in AD patients and control subjects using tape stripping of the stratum corneum (SC). The diffusion and partition coefficients were determined using Fick's second law of diffusion. The SC thickness was similar in both groups; however, the trans-epidermal water loss was higher in atopic skin. The apparent diffusion coefficient of PEGs through atopic skin was twice as high as through normal skin, and decreased with increasing molecular weight (MW) in both groups. The partition coefficient in the skin of AD patients was half of that for normal skin but as for normal skin, there was no MW dependency. Although atopic skin exhibited altered barrier with respect to diffusion and partitioning, the permeability coefficients were nearly the same for atopic and normal skin. The results support the assumption of altered skin barrier of AD patients even in the skin that is visibly unaffected by disease. SN - 1523-1747 UR - https://www.unboundmedicine.com/medline/citation/17039242/Altered_penetration_of_polyethylene_glycols_into_uninvolved_skin_of_atopic_dermatitis_patients_ DB - PRIME DP - Unbound Medicine ER -