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Breast cancer patients on adjuvant chemotherapy report a wide range of problems not identified by health-care staff.
Breast Cancer Res Treat 2007; 103(2):185-95BC

Abstract

BACKGROUND

Adjuvant chemotherapy for primary breast cancer is associated with significant side effects. The aims of this study were (1) to compare health-related quality of life (HRQL) in patients undergoing adjuvant chemotherapy to patients not on chemotherapy and (2) to compare these results against a survey investigating health-care professionals' knowledge of HRQL.

METHODS

Patients on adjuvant cyclophosphamide, methotrexate, fluoracil chemotherapy were compared to 'low-risk' patients not on chemotherapy ('control group'). A questionnaire including the EORTC QLQ-C30, the Hospital Anxiety and Depression Scale (HADS), and the DBCG 89 Questionnaire was administered six times during a 2-year period. Forty-six experienced health-care professionals were asked which quality-of-life issues they thought were affected by adjuvant chemotherapy.

RESULTS

After 2 years, 159 of 242 patients on chemotherapy and 148 of 199 patients in the control group were alive and recurrence-free and had completed all questionnaires. Worse HRQL during chemotherapy was seen, as had been previously suggested, for 23 of 30 variables. A number of the health-care professionals had not indicated patients to have these side effects. Several side effects persisted after the chemotherapy.

CONCLUSIONS

This study provides the most comprehensive description of HRQL in adjuvant therapy to date. The discrepancy between patients and doctors/nurses suggests that patients have been insufficiently informed about the impact of chemotherapy on quality of life. The results of this study provide a basis for information that can be given to patients, and indicate that the care offered to patients in chemotherapy should seek to prevent, identify, and alleviate a very broad range of problems.

Authors+Show Affiliations

The Research Unit, Department of Palliative Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark. mg02@bbh.hosp.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17039266

Citation

Groenvold, Mogens, et al. "Breast Cancer Patients On Adjuvant Chemotherapy Report a Wide Range of Problems Not Identified By Health-care Staff." Breast Cancer Research and Treatment, vol. 103, no. 2, 2007, pp. 185-95.
Groenvold M, Fayers PM, Petersen MA, et al. Breast cancer patients on adjuvant chemotherapy report a wide range of problems not identified by health-care staff. Breast Cancer Res Treat. 2007;103(2):185-95.
Groenvold, M., Fayers, P. M., Petersen, M. A., Sprangers, M. A., Aaronson, N. K., & Mouridsen, H. T. (2007). Breast cancer patients on adjuvant chemotherapy report a wide range of problems not identified by health-care staff. Breast Cancer Research and Treatment, 103(2), pp. 185-95.
Groenvold M, et al. Breast Cancer Patients On Adjuvant Chemotherapy Report a Wide Range of Problems Not Identified By Health-care Staff. Breast Cancer Res Treat. 2007;103(2):185-95. PubMed PMID: 17039266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer patients on adjuvant chemotherapy report a wide range of problems not identified by health-care staff. AU - Groenvold,Mogens, AU - Fayers,Peter M, AU - Petersen,Morten Aagard, AU - Sprangers,Mirjam A G, AU - Aaronson,Neil K, AU - Mouridsen,Henning T, Y1 - 2006/10/13/ PY - 2006/07/31/received PY - 2006/08/01/accepted PY - 2006/10/14/pubmed PY - 2007/8/3/medline PY - 2006/10/14/entrez SP - 185 EP - 95 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 103 IS - 2 N2 - BACKGROUND: Adjuvant chemotherapy for primary breast cancer is associated with significant side effects. The aims of this study were (1) to compare health-related quality of life (HRQL) in patients undergoing adjuvant chemotherapy to patients not on chemotherapy and (2) to compare these results against a survey investigating health-care professionals' knowledge of HRQL. METHODS: Patients on adjuvant cyclophosphamide, methotrexate, fluoracil chemotherapy were compared to 'low-risk' patients not on chemotherapy ('control group'). A questionnaire including the EORTC QLQ-C30, the Hospital Anxiety and Depression Scale (HADS), and the DBCG 89 Questionnaire was administered six times during a 2-year period. Forty-six experienced health-care professionals were asked which quality-of-life issues they thought were affected by adjuvant chemotherapy. RESULTS: After 2 years, 159 of 242 patients on chemotherapy and 148 of 199 patients in the control group were alive and recurrence-free and had completed all questionnaires. Worse HRQL during chemotherapy was seen, as had been previously suggested, for 23 of 30 variables. A number of the health-care professionals had not indicated patients to have these side effects. Several side effects persisted after the chemotherapy. CONCLUSIONS: This study provides the most comprehensive description of HRQL in adjuvant therapy to date. The discrepancy between patients and doctors/nurses suggests that patients have been insufficiently informed about the impact of chemotherapy on quality of life. The results of this study provide a basis for information that can be given to patients, and indicate that the care offered to patients in chemotherapy should seek to prevent, identify, and alleviate a very broad range of problems. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/17039266/Breast_cancer_patients_on_adjuvant_chemotherapy_report_a_wide_range_of_problems_not_identified_by_health_care_staff_ L2 - https://doi.org/10.1007/s10549-006-9365-y DB - PRIME DP - Unbound Medicine ER -