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Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort.
Neurogastroenterol Motil 2006; 18(11):987-94NM

Abstract

Obesity has been associated with increased reporting of gastrointestinal (GI) symptoms, but whether weight gain or loss causes symptoms is unclear. We studied the association between changes in body weight and changes in upper GI symptoms. Prospective cohort study on random samples of Olmsted County, MN residents. Distinct upper GI symptom complexes [gastro-oesophageal reflux disease (GERD), chest pain, dyspepsia- pain predominant, dyspepsia-dysmotility] were defined. Subjects with persistent, new-onset or disappearing symptoms were identified as cases, subjects with no reported symptoms in any of the surveys served as controls. Associations were studied in a logistic regression model, using age, gender, baseline Body Mass Index and somatic symptom score as covariates. Participants for whom baseline and follow-up data were available (n = 637) had a median time between surveys of 10.5 years. Baseline body weight was associated with GERD, chest pain and dyspepsia-pain predominant symptom complexes. An increase in body weight >10 lb between surveys was associated with new onset of dyspepsia-dysmotility (OR 5.57, 95% CI 1.91, 16.2). No association was found between weight loss >10 lb and the studied symptom complexes. Moderate body weight increases and decreases are generally not associated with upper GI symptom changes over time in the general population.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17040409

Citation

Cremonini, F, et al. "Relationship Between Upper Gastrointestinal Symptoms and Changes in Body Weight in a Population-based Cohort." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 18, no. 11, 2006, pp. 987-94.
Cremonini F, Locke GR, Schleck CD, et al. Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort. Neurogastroenterol Motil. 2006;18(11):987-94.
Cremonini, F., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2006). Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 18(11), pp. 987-94.
Cremonini F, et al. Relationship Between Upper Gastrointestinal Symptoms and Changes in Body Weight in a Population-based Cohort. Neurogastroenterol Motil. 2006;18(11):987-94. PubMed PMID: 17040409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort. AU - Cremonini,F, AU - Locke,G R,3rd AU - Schleck,C D, AU - Zinsmeister,A R, AU - Talley,N J, PY - 2006/10/17/pubmed PY - 2006/12/29/medline PY - 2006/10/17/entrez SP - 987 EP - 94 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 18 IS - 11 N2 - Obesity has been associated with increased reporting of gastrointestinal (GI) symptoms, but whether weight gain or loss causes symptoms is unclear. We studied the association between changes in body weight and changes in upper GI symptoms. Prospective cohort study on random samples of Olmsted County, MN residents. Distinct upper GI symptom complexes [gastro-oesophageal reflux disease (GERD), chest pain, dyspepsia- pain predominant, dyspepsia-dysmotility] were defined. Subjects with persistent, new-onset or disappearing symptoms were identified as cases, subjects with no reported symptoms in any of the surveys served as controls. Associations were studied in a logistic regression model, using age, gender, baseline Body Mass Index and somatic symptom score as covariates. Participants for whom baseline and follow-up data were available (n = 637) had a median time between surveys of 10.5 years. Baseline body weight was associated with GERD, chest pain and dyspepsia-pain predominant symptom complexes. An increase in body weight >10 lb between surveys was associated with new onset of dyspepsia-dysmotility (OR 5.57, 95% CI 1.91, 16.2). No association was found between weight loss >10 lb and the studied symptom complexes. Moderate body weight increases and decreases are generally not associated with upper GI symptom changes over time in the general population. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/17040409/Relationship_between_upper_gastrointestinal_symptoms_and_changes_in_body_weight_in_a_population_based_cohort_ L2 - https://doi.org/10.1111/j.1365-2982.2006.00816.x DB - PRIME DP - Unbound Medicine ER -