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Diagnosing major depressive disorder VIII: are some symptoms better than others?
J Nerv Ment Dis. 2006 Oct; 194(10):785-90.JN

Abstract

The present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services project examined whether symptoms that are not part of the DSM-IV definition of major depressive disorder (MDD) are better at discriminating depressed from nondepressed patients than the current criteria. Symptoms assessed included diminished drive, helplessness, hopelessness, nonreactive mood, psychic anxiety, somatic anxiety, subjective anger, and overtly expressed anger. A total of 1538 psychiatric outpatients were administered a semistructured diagnostic interview. We inquired about all of the symptoms of depression for all patients. Diminished drive exhibited stronger performance in differentiating MDD from non-MDD relative to all DSM-IV criteria except depressed mood, reduced interest/pleasure, and impaired concentration/indecisiveness. A compound criterion combining diminished drive with loss of energy was endorsed by nearly all MDD patients. Helplessness and hopelessness, when combined into a single criterion, performed more strongly than some of the DSM-IV criteria. Lack of reactivity, anxiety, and anger symptoms failed to differentiate more strongly than current DSM-IV criteria. The implications of these results for revising the diagnostic criteria for major depression are discussed.

Authors+Show Affiliations

Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17041292

Citation

McGlinchey, Joseph B., et al. "Diagnosing Major Depressive Disorder VIII: Are some Symptoms Better Than Others?" The Journal of Nervous and Mental Disease, vol. 194, no. 10, 2006, pp. 785-90.
McGlinchey JB, Zimmerman M, Young D, et al. Diagnosing major depressive disorder VIII: are some symptoms better than others? J Nerv Ment Dis. 2006;194(10):785-90.
McGlinchey, J. B., Zimmerman, M., Young, D., & Chelminski, I. (2006). Diagnosing major depressive disorder VIII: are some symptoms better than others? The Journal of Nervous and Mental Disease, 194(10), 785-90.
McGlinchey JB, et al. Diagnosing Major Depressive Disorder VIII: Are some Symptoms Better Than Others. J Nerv Ment Dis. 2006;194(10):785-90. PubMed PMID: 17041292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosing major depressive disorder VIII: are some symptoms better than others? AU - McGlinchey,Joseph B, AU - Zimmerman,Mark, AU - Young,Diane, AU - Chelminski,Iwona, PY - 2006/10/17/pubmed PY - 2006/11/15/medline PY - 2006/10/17/entrez SP - 785 EP - 90 JF - The Journal of nervous and mental disease JO - J Nerv Ment Dis VL - 194 IS - 10 N2 - The present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services project examined whether symptoms that are not part of the DSM-IV definition of major depressive disorder (MDD) are better at discriminating depressed from nondepressed patients than the current criteria. Symptoms assessed included diminished drive, helplessness, hopelessness, nonreactive mood, psychic anxiety, somatic anxiety, subjective anger, and overtly expressed anger. A total of 1538 psychiatric outpatients were administered a semistructured diagnostic interview. We inquired about all of the symptoms of depression for all patients. Diminished drive exhibited stronger performance in differentiating MDD from non-MDD relative to all DSM-IV criteria except depressed mood, reduced interest/pleasure, and impaired concentration/indecisiveness. A compound criterion combining diminished drive with loss of energy was endorsed by nearly all MDD patients. Helplessness and hopelessness, when combined into a single criterion, performed more strongly than some of the DSM-IV criteria. Lack of reactivity, anxiety, and anger symptoms failed to differentiate more strongly than current DSM-IV criteria. The implications of these results for revising the diagnostic criteria for major depression are discussed. SN - 0022-3018 UR - https://www.unboundmedicine.com/medline/citation/17041292/Diagnosing_major_depressive_disorder_VIII:_are_some_symptoms_better_than_others L2 - https://doi.org/10.1097/01.nmd.0000240222.75201.aa DB - PRIME DP - Unbound Medicine ER -