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Hepcidin--central regulator of iron metabolism.
Eur J Haematol. 2007 Jan; 78(1):1-10.EJ

Abstract

The knowledge about mammalian iron metabolism has advanced dramatically over the past decades. Studies of genetics, biochemistry and molecular biology allowed us the identification and characterization of many of the molecules involved in regulation of iron homeostasis. Important progresses were made after the discovery in 2000 of a small peptide--hepcidin--that has been proved to play a central role in orchestration on iron metabolism also providing a link between iron metabolism and inflammation and innate immunity. Hepcidin directly interacts with ferroportin (FPN), the only known mammalian iron exporter, which is expressed by enterocytes, macrophages and hepatocytes. The direct hepcidin-FPN interaction allows an adaptative response from the body in situations that alter normal iron homeostasis (hypoxia, anemia, iron deficiency, iron overload, and inflammation).

Authors+Show Affiliations

Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, Bucharest, Romania.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17042775

Citation

Atanasiu, Valeriu, et al. "Hepcidin--central Regulator of Iron Metabolism." European Journal of Haematology, vol. 78, no. 1, 2007, pp. 1-10.
Atanasiu V, Manolescu B, Stoian I. Hepcidin--central regulator of iron metabolism. Eur J Haematol. 2007;78(1):1-10.
Atanasiu, V., Manolescu, B., & Stoian, I. (2007). Hepcidin--central regulator of iron metabolism. European Journal of Haematology, 78(1), 1-10.
Atanasiu V, Manolescu B, Stoian I. Hepcidin--central Regulator of Iron Metabolism. Eur J Haematol. 2007;78(1):1-10. PubMed PMID: 17042775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepcidin--central regulator of iron metabolism. AU - Atanasiu,Valeriu, AU - Manolescu,Bogdan, AU - Stoian,Irina, Y1 - 2006/10/17/ PY - 2006/10/18/pubmed PY - 2007/3/21/medline PY - 2006/10/18/entrez SP - 1 EP - 10 JF - European journal of haematology JO - Eur J Haematol VL - 78 IS - 1 N2 - The knowledge about mammalian iron metabolism has advanced dramatically over the past decades. Studies of genetics, biochemistry and molecular biology allowed us the identification and characterization of many of the molecules involved in regulation of iron homeostasis. Important progresses were made after the discovery in 2000 of a small peptide--hepcidin--that has been proved to play a central role in orchestration on iron metabolism also providing a link between iron metabolism and inflammation and innate immunity. Hepcidin directly interacts with ferroportin (FPN), the only known mammalian iron exporter, which is expressed by enterocytes, macrophages and hepatocytes. The direct hepcidin-FPN interaction allows an adaptative response from the body in situations that alter normal iron homeostasis (hypoxia, anemia, iron deficiency, iron overload, and inflammation). SN - 0902-4441 UR - https://www.unboundmedicine.com/medline/citation/17042775/Hepcidin__central_regulator_of_iron_metabolism_ L2 - https://doi.org/10.1111/j.1600-0609.2006.00772.x DB - PRIME DP - Unbound Medicine ER -